October 2022 - Page 262 of 406 - Alcohols-buliding-blocks

Wang, Jinmin’s team published research in Analytical Chemistry (Washington, DC, United States) in 2019 | CAS: 34374-88-4

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.SDS of cas: 34374-88-4

《Improving Covalent Organic Frameworks Fluorescence by Triethylamine Pinpoint Surgery as Selective Biomarker Sensor for Diabetes Mellitus Diagnosis》 was written by Wang, Jinmin; Yan, Bing. SDS of cas: 34374-88-4This research focused ontriethylamine covalent organic framework fluorescent sensor diabetes biomarker. The article conveys some information:

The nitrogen-containing imine or hydrazone linked covalent organic frameworks (COFs) are poorly luminescent due to the fluorescence quenching by nitrogen atoms in the linkages, even if highly luminescent units and linkers are employed. The fluorescence quenching pathway to prevent linkage-originated to mitigate the inherent limitations of the linkage is a promising method for luminescent COFs. The generation of N- by deprotonation of the N-H unit eliminates the electron transfer from N lone pair to COF (TpPa-1) and enhances the luminescence. In this work, TpPa-1 achieved turn-on luminescence response with good sensitivity and reproducibility toward triethylamine (TEA) vapor in the process of deprotonation. The fabricated detector offers a viable approach for sensing ppm-level TEA, which can remind people to take timely measures to reduce the environmental hazards caused by TEA. The fluorescent sensor TpPa-1@LE constructed by the products of TpPa-1 and TEA can quant. trace biomarker methylglyoxal (MGO) for diabetes mellitus diagnosis in serum system. Furthermore, using TEA and MGO as input signals and the two fluorescence emissions G476 and Y525 as output signals, an advanced anal. device based on two Boolean logic gates with INH and AND function is constructed. This work provides a new strategy for improving the weak luminescence of COF in aqueous solution and realizes selective response to biomarker (MGO) for diabetes mellitus diagnosis. The results came from multiple reactions, including the reaction of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4SDS of cas: 34374-88-4)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

de Albuquerque, Danilo Yano’s team published research in European Journal of Organic Chemistry in 2019 | CAS: 13325-10-5

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol

《Palladium-Catalyzed Aminocarbonylation Reaction to Access 1,2,3-Triazole-5-carboxamides Using Dimethyl Carbonate as Sustainable Solvent》 was written by de Albuquerque, Danilo Yano; de Moraes, Juliana R.; Schwab, Ricardo S.. Name: 4-Aminobutan-1-olThis research focused ontriazole carboxamide preparation; amine iodotriazole formic acid carbonylative coupling. The article conveys some information:

A simple and direct palladium-catalyzed aminocarbonylation of 5-iodo-1,2,3-triazoles backbone for the incorporation of an amide functional group was presented. The approach was based on the palladium catalyzed carbonylative coupling reaction of iodo-triazole with different amines employing formic acid and sulfuric acid as CO source (Morgan’s reaction) to provide the 1,2,3-triazole-5-carboxamides I [R = Bn, 4-OMeC6H4, C10H21, etc.; R1 = H, n-Bu, Ph, etc.] in good to excellent yields. The important features of this methodol. included short reaction time, high yields, the use of di-Me carbonate as a sustainable solvent and the use of efficient alternative source of carbon monoxide, avoiding pressurized cylinder. The methodol. described herein for the synthesis of 1,4,5-trisubstituted 1,2,3-triazole-5-carboxamides I, could offer an alternative path for functionalization of other heterocycles. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chantasart, Doungdaw’s team published research in Journal of Drug Delivery Science and Technology in 2019 | CAS: 54-17-1

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.SDS of cas: 54-17-1

《Preparation and characterization of dry β-cyclodextrin-based ternary complexes of haloperidol and lactic acid for drug delivery》 was written by Chantasart, Doungdaw; Rakkaew, Prisada. SDS of cas: 54-17-1 And the article was included in Journal of Drug Delivery Science and Technology on August 31 ,2019. The article conveys some information:

This study was aimed to prepare dry β-cyclodextrin (β-CD)-based ternary complexes of haloperidol (HALO) with lactic acid for drug delivery. The influences of different media (buffers pH 3 and pH 6) and preparation methods ((freeze drying (FD) and solvent evaporation (SE)) on the HALO inclusion complexes were determined HALO/β-CD/lactic acid ternary complexes prepared in buffer pH 3 exhibited higher inclusion yield than those in buffer pH 6. Furthermore, HALO/β-CD/lactic acid ternary complexes prepared via FD gave higher inclusion yield than those prepared via SE. The physicochem. properties of dry HALO/β-CD/lactic acid ternary complexes prepared in buffer pH 3 were subsequently determined The interaction of HALO, β-CD and lactic acid was found and confirmed by Fourier transform IR and proton NMR. Results from differential scanning calorimetry and X-ray powder diffractometry depicted that the β-CD ternary complexes of HALO and lactic acid prepared via FD in buffer pH 3 transformed the drug from a crystalline state to an amorphous state. With significantly enhanced release of HALO from the complexes, HALO/β-CD/lactic acid ternary complexes was shown to be a promising carrier for HALO delivery. In the experiment, the researchers used rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1SDS of cas: 54-17-1)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nieuwenhuijzen, Jose W.’s team published research in Angewandte Chemie, International Edition in 2002 | CAS: 157142-48-8

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Related Products of 157142-48-8

Related Products of 157142-48-8On November 15, 2002 ,《The role of nucleation inhibition in optical resolutions with families of resolving agents》 appeared in Angewandte Chemie, International Edition. The author of the article were Nieuwenhuijzen, Jose W.; Grimbergen, Reinier F. P.; Koopman, Carla; Kellogg, Richard M.; Vries, Ton R.; Pouwer, Kees; van Echten, Erik; Kaptein, Bernard; Hulshof, Lumbertus A.; Broxterman, Quirinius B.. The article conveys some information:

The role of nucleation inhibition during Dutch resolution (DR) of several compounds in the presence of various additives is investigated. Significant improvements in the diastereomeric excesses (de values) of the salt products are observed The overall results indicated that the nucleation inhibition and associated kinetic effects can play a role in DR leading to a second generation of DR, namely the use of small amounts of a certain family member of the resolving agent as an additive. In the experiment, the researchers used many compounds, for example, 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Related Products of 157142-48-8)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yan, Guobing’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2010 | CAS: 401797-00-0

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group.Related Products of 401797-00-0 Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.

Related Products of 401797-00-0On May 14, 2010 ,《Nano-Fe2O3-catalyzed direct borylation of arenes》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Yan, Guobing; Jiang, Yubo; Kuang, Chunxiang; Wang, Shuai; Liu, Haichao; Zhang, Yan; Wang, Jianbo. The article conveys some information:

Nano-Fe2O3-catalyzed borylation of arenes with diboron pinacol ester B2pin2 has been found to give borylation products with selectivity controlled by electronic effects of substituents. The experimental part of the paper was very detailed, including the reaction process of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Related Products of 401797-00-0)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fonseca-Santos, Bruno’s team published research in International Journal of Pharmaceutics (Amsterdam, Netherlands) in 2020-11-15 | 501-36-0

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about Central nervous system agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Synthetic Route of 501-36-0 .

Fonseca-Santos, Bruno; Chorilli, Marlus published the artcile< The uses of resveratrol for neurological diseases treatment and insights for nanotechnology based-drug delivery systems>, Synthetic Route of 501-36-0 , the main research area is review resveratrol neurol disease nanotechnol; Blood–brain barrier; Brain; Nanocarriers; Nanomedicines; Nasal drug delivery; Resveratrol.

A review. Neurol. disorders have been growing in recent years and are highly prevalent globally. Resveratrol (RES) is a natural product from plant sources such as grape skins. This compound has shown biol. activity in many diseases, in particular, those that act on the central nervous system. The mechanism of action and the key points in neurol. disorders were described and show the targeted mechanism of action. Due to the insolubility of this compound; the use of nanotechnol.-based systems has been proposed for the incorporation of RES and RES-loaded nanocarriers have been designed for intranasal administration, oral or parenteral routes to deliver it to the brain. In general, these nanosystems have shown to be effective in many studies, pharmacol. and pharmacokinetic assays, as well as some cell studies. The outcomes show that RES has been reported in human clin. trials for some neurol. diseases, although no studies were performed in humans using nanocarriers, animal and/or cellular models have been reported to show good results regarding therapeutics on neurol. diseases. Thus, the use of this nutraceutical has shown true for neurol. diseases and its loading into nanocarriers displaying good results on the stability, delivery and targeting to the brain.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kishore, M’s team published research in International Journal of Pharmacy and Technology in 2016 | 6054-98-4

International Journal of Pharmacy and Technology published new progress about Compressibility. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Computed Properties of 6054-98-4.

Kishore, M.; VijayaKumar, B.; NarasimhaReddy, Y. published the artcile< Formulation and evaluation of olsalazine sodium enteric coated tablets in ulcerative colitis>, Computed Properties of 6054-98-4, the main research area is olsalazine sodium enteric tablet coating ulcerative colitis.

Aim: To formulate and evaluate the fabricated olsalazine sodium enteric coated tablets in ulcerative colitis and also compare the In-vitro dissolution profile of optimized Olsalazine sodium enteric coated tablets in the presence of β- glycosidase at targeted colonic region. Materials: Olsalazine sodium, obtained as a gift sample from Aurbindo Pharmaceuticals Hyderabad, Telangana, and India. Et cellulose, Chitosan, PVP K30, Magnesium stearate, Lactose, Eudragit S-100, Acetone, Tri-Et citrate was used as a plasticizer etc. All the above polymers and excipients are obtained from S.D Fine Chems., Mumbai. Conclusion: The present study was fabricated to observe the drug release of Olsalazine sodium enteric coated tablets at targeted site specific colon region. These tablets were formulated from F1-F8 by selecting time dependent and release retard biodegrable polymers such as Et cellulose-chitosan composite by combining with different concentrations by wet granulation. This composite was included in this study to control the solubility of premature drug release in gastrointestinal fluid and in this regard, the above formulation F6 was optimized and coated with Eudragit-S 100 as enteric polymer as to retard the drug release at specified site colon by changing suitable concentration as like 1, 3, 5, and7 %. From which F6 containing 5% Eudragit-S 100 was shown only 75.6 % drug release in 24 h and also it was compared with dissolution medium containing β-glycosidase. In which enzymic condition the above formulation enhanced the drug release i.e, 98.3% was found in 24 h. Finally the current study was contributed to evaluated all pre, post compressional parameters of optimized formulation with various release kinetic mechanism such as zero order, first order, higuchi plot and peppas mayer equations studies.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Talukdar, Hiya’s team published research in Molecular Catalysis in 2021-11-30 | 699-12-7

Molecular Catalysis published new progress about Epoxides Role: SPN (Synthetic Preparation), PREP (Preparation). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, SDS of cas: 699-12-7.

Talukdar, Hiya; Gogoi, Sandhya Rani; Saikia, Gangutri; Sultana, Sazida Yasmin; Ahmed, Kabirun; Islam, Nashreen S. published the artcile< A sustainable approach towards solventless organic oxidations catalyzed by polymer immobilized Nb(V)-peroxido compounds with H2O2 as oxidant>, SDS of cas: 699-12-7, the main research area is peroxidoniobium complex immobilized polystyrene divinylbenzene resin catalyst preparation; epoxide preparation; styrene oxidation niobium catalyst; sulfone preparation; thioether oxidation niobium catalyst.

New heterogeneous catalysts comprising of peroxidoniobium(V) complexes immobilized on amino acid grafted cross-linked poly(styrene-divinylbenzene) resin was developed. Results of FTIR, Raman, NMR, XPS, XRD, EDX, SEM, BET, TGA, and elemental anal. confirmed the successful anchoring of triperoxidoniobium(V), [Nb(O2)3]- species to the host polymer via the pendant amino acid groups. The supported catalysts exhibited excellent performance in epoxidation of styrene and a range of cyclic and terpenic compounds under environmentally acceptable solvent-free condition, with aqueous H2O2 as oxidant. The catalytic protocols provided excellent conversion to the desired epoxide (up to 100%) with selectivity > 99%, TON as high as 1000, and high H2O2 utilization efficiency (92-97%). Moreover, the catalysts efficiently facilitated chemoselective solvent-free oxidation of a variety of thioethers to sulfones at room temperature Simple operational strategy, easy recyclability for multiple reaction cycles with the consistent activity-selectivity profile are the addnl. significant attributes of the developed catalytic processes.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Yachao’s team published research in Chinese Chemical Letters in 2021-02-28 | 627-27-0

Chinese Chemical Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Zhang, Yachao; Mao, Liang-Liang; Hu, Sifan; Luan, Yi; Cong, Huan published the artcile< Photo-induced anti-Markovnikov hydroalkylation of unactivated alkenes employing a dual-component initiator>, Recommanded Product: But-3-en-1-ol, the main research area is cyanoester preparation; unactivated alkene photochem anti Markovnikov hydroalkylation dual component initiator.

Metal-free anti-Markovnikov hydroalkylation of unactivated alkenes RCH=CH2 (R = cyclohexyl, 9-(1,3-dioxolan-2-yl)nonyl, 10-methoxy-10-oxodecyl, etc.) with Et cyanoacetate has been developed, featuring the use of a dual-component initiator containing an organic photocatalyst and a radical precursor. When combined, the two components can undergo visible light-induced single-electron transfer, and serve as a versatile and effective alkyl radical generator.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Samaha, Hala’s team published research in Molecules in 2021 | 492-62-6

Molecules published new progress about Antioxidants. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, HPLC of Formula: 492-62-6.

Samaha, Hala; Chahine, Nathalie; Sobolev, Anatoly Petrovich; Menghini, Luigi; Makhlouf, Hassane published the artcile< 1H-NMR Metabolic Profiling and Antioxidant Activity of Saffron (Crocus sativus) Cultivated in Lebanon>, HPLC of Formula: 492-62-6, the main research area is Crocus sativus antioxidant cultivation NMR metabolic profiling; Lebanon; NMR; geographical classification; metabolic profiling; microwave-assisted extraction; saffron.

Despite the beneficial health properties shown by Lebanese saffron, its qual. and quant. composition has never been investigated before. In the present study, NMR spectroscopy, together with antioxidant activity assays, were applied to evaluate the chem. composition of saffron samples of different geog. origins (Lebanon, Italy, Iran, and India) and to categorize the Lebanese saffron for the first time. The distinction between Lebanese saffron and that produced in other countries was attributed to its higher linolenic and linoleic fatty acids, glucose and picrocrocin contents. Moreover, spices produced in three different regions of the Lebanese territory have been clearly differentiated. Saffron cultivated in the Qaa region displayed a high glucose, fatty acids and polyphenols content, whereas Hermel saffron exhibited the largest rate of picrocrocin and glycosylated carotenoids. Finally, samples from Baalbeck showed lower rates for the majority of metabolites. Moreover, Lebanese saffron showed a high antioxidant activity in ABTS and DPPH assays. A low dose of saffron extract (10 μg/mL) inhibited the growth of human lung adenocarcinoma cells, probably due to the high polyphenolic content. This study highlights the quality and peculiarity of Lebanese saffron cultivated in Northern Beqaa district and allows for a good discrimination between spices produced in relatively close territory.

Molecules published new progress about Antioxidants. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, HPLC of Formula: 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts