Month: October 2022

Guo, Honglei; Guo, Qianqian; Lan, Tianyu; Luo, Yongjun; Pan, Xiuhao; Yao, Yifang; Li, Yafei; Feng, Ya; Liu, Yujia; Tao, Ling; Shen, Xiangchun published their research in Journal of Biomaterials Science, Polymer Edition in 2021. The article was titled 《Amphiphilic block versus random copolymer nanoparticles with reactive oxygen species responsiveness as berberine vehicles》.Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane The article contains the following contents:

A series of amphiphilic block and random copolymers based on phenylboronic acid pinacol ester were synthesized via reversible addition-fragmentation chain transfer polymerization The obtained copolymers can self-assemble in aqueous solution into stable block copolymer nanoparticles and random nanoparticles with sizes of 116.1-158.6 and 126.3-187.0 nm, resp. All nanoparticles showed hydrogen peroxide (H2O2) sensitivity, and the random copolymer nanoparticles presented faster responsiveness to H2O2 than did those derived from block copolymers. Berberine (BBR) can be effectively encapsulated into block and random copolymer nanoparticles with loading capacity of 7.6%-9.1% and 7.3%-8.9%, resp. The BBR release can be controlled in an H2O2 medium. For the random copolymer nanoparticles, the release rate of BBR was faster and the cumulative release amounts in response to H2O2 were higher over 48 h. The BBR cumulative release amount in the H2O2 medium for the block and random copolymer nanoparticles was 62.2%-70.2% and 68.6%-80.4%, resp. Moreover, good biocompatibility was observed for the BBR-loaded block and random copolymer nanoparticles. BBR and BBR-loaded nanoparticles can improve Glut4 translocation to the cell membrane and promote glucose transport into cells. BBR-loaded nanoparticles can decrease the blood glucose levels in diabetic rats over 15 days. These results imply that the different chain formulation of block and random copolymers affects the H2O2 responsiveness and that the two kinds of nanoparticles exhibit potential application as novel vehicles for BBR delivery to regulate blood glucose levels. The results came from multiple reactions, including the reaction of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Recommanded Product: 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

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Delabie, Jonas; Ceunen, Ward; Detavernier, Siebe; De Winter, Julien; Gerbaux, Pascal; Verbiest, Thierry; Koeckelberghs, Guy published their research in Macromolecules (Washington, DC, United States) in 2021. The article was titled 《Catechol as a Universal Linker for the Synthesis of Hybrid Polyfluorene/Nanoparticle Materials》.Reference of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane The article contains the following contents:

The attachment of conjugated polymers (CPs), characterized by their optical and electronic properties and excellent processability, to inorganic nanoparticles (NPs), known for their specialized electronic and photonic properties, has proven to result in unique and promising (hybrid) materials. Although CPs can be functionalized with many different end groups, the process to find a correct match between the desired NP and appropriate functional group on the CP is often tedious and time-consuming. This study aims to solve this problem by investigating the potential of catechol as a universal linker mol. for the synthesis of hybrid CP/NP materials. First, the synthesis of poly(9,9-di((S)-3,7-dimethyloctyl)fluorene) via Suzuki-Miyaura catalyst transfer oxidative polycondensation using an external catechol Pd-initiator is studied. A chain-growth polymerization without transfer reactions for molar masses up to 28.3 kg mol-1 is established without degradation of the catechol in basic environments. These polymers are subsequently used to graft a variety of NP materials, including magnetic- (Fe3O4), plasmonic- (Au), and oxide-type (SiO2) NPs, proving its potential as a universal linker mol. In addition, the influence of the catechol group on the supramol. organization of free polyfluorene is studied by comparison with the well-known o-tolyl end-capped polyfluorenes. From these results, it can be concluded that the catechol group significantly disrupts the formation of well-defined supramol. architectures. Finally, as a preliminary study, the supramol. organization of the hybrid NPs is compared to the free polymer using solvatochromism experiments The results indicate an absence of chiral response upon fixation of the polymer onto a surface. In the experiment, the researchers used many compounds, for example, 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6Reference of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) can be used as a substrate in the study of Suzuki–Miyaura coupling of various aryl iodides over SiliaCat Pd(0).Reference of 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane

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Guo, Ke; Zhu, Xiaoli; Peng, Lianlian; Fu, Yanghe; Ma, Rui; Lu, Xinqing; Zhang, Fumin; Zhu, Weidong; Fan, Maohong published an article in 2021. The article was titled 《Boosting photocatalytic CO2 reduction over a covalent organic framework decorated with ruthenium nanoparticles》, and you may find the article in Chemical Engineering Journal (Amsterdam, Netherlands).Product Details of 34374-88-4 The information in the text is summarized as follows:

The conversion of CO2 into valuable chems. utilizing solar energy is one of the most promising approaches to solve the problems associated with global warming and energy shortage. Considering more and more covalent organic frameworks (COFs) that have been reported, the great potential of COFs as photocatalysts for CO2 reduction is still appreciated to a limited extent. In the current work, Ru nanoparticles (NPs) loaded ketoamine-based COF (TpPa-1) catalysts, named Ru/TpPa-1, were developed for the photocatalytic reduction of CO2 upon visible-light irradiation for the first time. Compared with TpPa-1, Ru/TpPa-1 catalysts exhibit a significantly enhanced activity for the photoreduction of CO2. In combination with the results from some extensive characterizations, it is found that the interactions between the Ru NPs and TpPa-1 can enhance the visible-light harvesting and create a new way to extend the service life of photo-generated charge carriers via facilitating the electron transfer through the loaded Ru NPs. The current investigation, therefore, provides a photocatalytic approach for CO2 fixation, enriches the theory of photocatalysis, and enlarges the application of COF-based materials. In the experiment, the researchers used many compounds, for example, 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Product Details of 34374-88-4)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Regarding monomeric phloroglucinols, this group encompasses acryl phloroglucinols, phloroglucinol-terpene adducts, phloroglucinol glycosides, halogenated phloroglucinols, prenylated phloroglucinols, and cyclicroup polyketides.Product Details of 34374-88-4

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Zhenming Chen; Gui, Chengmei; Wei Yao; Li, Peng published an article in 2022. The article was titled 《Polymer Brush Induced Electroless Copper Plating on PA12 Surface for Tensile Strength Enhancement of Selective Laser Sintering Part》, and you may find the article in Journal of Materials Engineering and Performance.Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The information in the text is summarized as follows:

Metal particles can be deposited on nylon 12 (PA12) surface with excellent metal/substrate interface and distribution by electroless plating (EP), but the use of noble metal as EP catalyst would enhance the cost of raw materials and restrict its application. In this work, we developed a polymer brush (PB)-induced EP method to prepare Cu particle/PA12 composite powder (CPP) as an enhancing component for improving the strength of the selective laser sintering (SLS) part. The results showed hydrolyzed 3-amino-propyltriethoxysilane attached on the modified PA12 surface, which presented in PB form. The PB effectively reduced the stability of [Cu-EDTA] complex and REDOX barrier, subsequently, PB acted as catalytic site to reduce Cu ion into Cu metal by EP. The deposit consisted of Cu particles (spherical, about 1μm) and a small quantity of Cu2O particles (cubic, about 0.3μm), the ratio of Mplated particle/M(plated particle+PA12) is 15%. The PA12 particles were spheroidized firstly, then formed sintered neck during neighboring particles and sintered body in turn under laser action. Based on the excellent Cu/PA12 interface and dispersion, the tensile strength of the SLS part sintered with 10 W laser energy increased by an average of around 26.2% to 53 MPa.Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate) was used in this study.

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Reference of Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate Potassium sodium tartrate tetrahydrate has been used in the preparation of Lowry reagent for the determination of microsomal protein concentration in rat hepatic microsomes by Lowry method.

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In 2022,Boukherrouba, Emeline; Larosa, Camille; Nguyen, Kim-Anh; Caburet, Jeremy; Lunven, Laurent; Bonnet, Hugues; Fortune, Antoine; Boumendjel, Ahcene; Boucherle, Benjamin; Chierici, Sabine; Peuchmaur, Marine published an article in European Journal of Medicinal Chemistry. The title of the article was 《Exploring the structure-activity relationship of benzylidene-2,3-dihydro-1H-inden-1-one compared to benzofuran-3(2H)-one derivatives as inhibitors of tau amyloid fibers》.Application of 26153-38-8 The author mentioned the following in the article:

Tauopathies, such as Alzheimer′s disease, have been the subject of several hypotheses regarding the way to treat them. Hyperphosphorylation of tau protein leading to its aggregation is widely recognized as a key step in the development of these diseases resulting in neuronal dysfunction. The AcPHF6 model of tau that includes the shorter critical fragment involved in the protein aggregation was used in vitro to identify new potential inhibitors. Following a previous study on aurone derivatives, we herein compare this polyphenol family to a very close one, the benzylidene-2,3-dihydro-1H-inden-1-one (also named indanone). The structure activity relationship studies bring to light the importance of the hydroxylation pattern in both series: the more hydroxylated, the more active. In addition, the three-dimensional shape of the mols. is involved in their interaction mode with their target, thus defining their role either as inhibitors of fiber elongation or as fiber-binding mols. Indanone 13a was identified as a promising inhibitor: its activity was confirmed by CD and at. force microscopy studies. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Application of 26153-38-8) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Application of 26153-38-8

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Quality Control of 3-PyridinemethanolIn 2019 ,《Room temperature N-heterocyclic carbene manganese catalyzed selective N-alkylation of anilines with alcohols》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Huang, Ming; Li, Yukui; Li, Yinwu; Liu, Jiahao; Shu, Siwei; Liu, Yan; Ke, Zhuofeng. The article contains the following contents:

The first example of room temperature non-noble metal homogeneous system catalyzed selective N-alkylation of anilines with alcs. by a bis-NHC manganese complex is presented. This system was applied to a large range of alcs. and anilines, including biol. relevant motifs and challenging methanol. Exptl. and computational studies suggest an outer-sphere mechanism for this NHC-Mn system. The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0Quality Control of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Quality Control of 3-Pyridinemethanol

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Name: 3,5-DihydroxybenzaldehydeIn 2019 ,《Fungal endophyte Phomopsis liquidambari biodegrades soil resveratrol: a potential allelochemical in peanut monocropping systems》 was published in Journal of the Science of Food and Agriculture. The article was written by Wang, Hong-Wei; Sun, Kai; Guan, Yong-Xiang; Qiu, Mei-Hua; Zhang, Li; Dai, Chuan-Chao. The article contains the following contents:

Most allelochems. are secondary products released from root excretions or plant residues that accumulate in continuous cropping systems and cause severe decline in peanut yield. Resveratrol is a plant-derived stilbene that is released from peanut residues and accumulates in the soil; however, its allelopathic effects on peanut production are overlooked. Effective management solutions need to be developed to relieve allelopathy caused by soil resveratrol. Here, the biodegradation of resveratrol by the fungal endophyte Phomopsis liquidambari was investigated in a mineral salt medium and a soil trial. Resveratrol and its metabolites (produced by degradation by P. liquidambari) were detected by high-performance liquid chromatog.-mass spectrometry (HPLC-MS). Resveratrol released from peanut residues reached a maximum concentration of 0.18μg g-1 soil in litterbag experiments Exogenous resveratrol inhibited peanut growth, nodule formation, and soil dehydrogenase activity, and reduced the soil microbial biomass carbon content and bacterial abundance, indicating an allelopathic role in peanut growth. More than 97% of the resveratrol was degraded within 72 and 168 h by P. liquidambari in pure culture and soil conditions, resp. Resveratrol was first cleaved to 3,5-dihydroxybenzaldehyde and 4-hydroxybenzaldehyde, which were subsequently oxidized into 3,5-dihydroxybenzoic acid and 4-hydroxybenzoic acid, resp. Fungal resveratrol cleavage oxygenase and the related gene expression were enhanced when P. liquidambari was induced by the resveratrol during the incubation. Our results indicate that the practical application of the fungal endophyte P. liquidambari has strong potential for biodegrading soil resveratrol, which can cause allelopathy in peanut continuous cropping systems, c 2019 Society of Chem. Industry. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Name: 3,5-Dihydroxybenzaldehyde

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COA of Formula: C9H6O6In 2019 ,《Ultrasensitive Determination of Tetrabromobisphenol A by Covalent Organic Framework Based Solid Phase Microextraction Coupled with Constant Flow Desorption Ionization Mass Spectrometry》 was published in Analytical Chemistry (Washington, DC, United States). The article was written by Gao, Wei; Tian, Yong; Liu, Huan; Cai, Yaqi; Liu, Aifeng; Yu, Yong-Liang; Zhao, Zongshan; Jiang, Guibin. The article contains the following contents:

Rapid detection of ultratrace pollutants in complex matrixes is a great challenge for studying their environmental behaviors and impacts. A method is developed by combining covalent organic framework (COF) based solid phase microextraction (SPME) with constant flow desorption ionization mass spectrometry for rapid detection of trace tetrabromobisphenol A (TBBPA) in multiple water media. The limits of detection and qualification are 0.92 and 3.1 ng L-1 for TBBPA, resp. The linear range is 0.01-10 μg L-1 (R2 = 0.9992), and the relative standard deviations with single fiber and multiple fibers are 6.4% and 6.7% (0.1 μg L-1, n = 9), resp. The detection of nanogram per L levels of TBBPA in tap water, river water, seawater, and beverage can be achieved in 7 min. In the experiment, the researchers used many compounds, for example, 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4COA of Formula: C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.COA of Formula: C9H6O6

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《Conformationally rigid derivatives of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin-1a receptors》 was written by Jorgensen, William T.; Gulliver, Damien W.; Katte, Timothy A.; Werry, Eryn L.; Reekie, Tristan A.; Connor, Mark; Kassiou, Michael. Safety of 3,5-DihydroxybenzaldehydeThis research focused onWAY 267464 conformationally rigid derivative preparation oxytocin vasopressin receptor; Arginine vasopressin 1(a) receptor; Diazepine; Oxytocin receptor; WAY-267,464. The article conveys some information:

WAY-267,464 (I) and twelve conformationally rigid analogs were synthesized, characterized and evaluated in cellular assays with the aim of systematically exploring interactions with the oxytocin receptor (OTR). Each analog was evaluated in radioligand binding displacement assays at both human OTR and arginine vasopressin 1a receptors (V1aR). Physiol. characterization was determined by whole cell IP1 accumulation assays on stably transfected human embryonic kidney (HEK) cells. Incorporation of the rigid, optionally substituted benzene ring abolished OTR activity and diminished V1aR pharmacol. when compared to I. A general trend was observed in V1aR affinity for the Pr analogs which identified the ortho-substituted analog II as the best in series (Ki = 251 nM) followed by a decrease in affinity through the meta and para-derivatives ( Ki = 874 nM, 1756 nM resp.). This study confirms the importance of the central pharmacophoric motifs of WAY-267,464 and illuminates the differences in the binding pocket of the highly conserved OTR and V1aR. The experimental process involved the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Safety of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Safety of 3,5-Dihydroxybenzaldehyde

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《Effective production of biofuel from used cooking oil over Ni-Pd loaded on amine-functionalized Lapindo Mud catalyst》 was written by Trisunaryanti, Wega; Alethiana, Afra; Falah, Iip Izul; Fatmawati, Dyah Ayu. Recommanded Product: Octadecan-9-ol And the article was included in Reaction Kinetics, Mechanisms and Catalysis on April 30 ,2022. The article conveys some information:

In the present work, Lapindo Mud (LL) as natural-based catalyst support material without any prior chem. extraction obtained from Sidoarjo, East Java comprising SiO2 (45.49%), Al2O3 (13.82%), and Fe2O3 (21.63%) was impregnated with the combination of Ni and/or Pd metal catalyst (i.e. LL, Ni/LL, Pd/LL, Ni-Pd/LL). The modification of heterogeneous catalyst (catalyst-support material) by the addition of amine-functionalized group from 3-APTMS compound (i.e. NH2/LL, Ni-NH2/LL, Pd-NH2/LL, and Ni-Pd-NH2/LL) to improve catalyst activity and selectivity towards Free Fatty Acid (FFA) in the hydro-treatment process of used cooking oil into biofuel was thoroughly compared. The result found that Ni-Pd-NH2/LL catalyst was able to generate the higher conversion of liquid product and to decrease the generation of FFA from 10.1 to 3.2% compared to the un-grafted Ni-Pd/LL catalyst. The study showed that the optimum temperature to produce hydrocarbons in hydro-treatment process using Ni-Pd-NH2/LL catalyst was at 550°C with 1/100 catalyst-to-feed weight ratio. The experimental part of the paper was very detailed, including the reaction process of Octadecan-9-ol(cas: 591-70-8Recommanded Product: Octadecan-9-ol)

Octadecan-9-ol(cas: 591-70-8) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Recommanded Product: Octadecan-9-ol

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