Month: October 2022

Yang, Zhongzhou; Li, Yueqing; Gao, Fengzhan; Jin, Wei; Li, Shuying; Kimani, Shadrack; Yang, Song; Bao, Tingting; Gao, Xiang; Wang, Li published the artcile< MYB21 interacts with MYC2 to control the expression of terpene synthase genes in flwers of Freesia hybrida and Arabidopsis thaliana>, SDS of cas: 78-70-6, the main research area is terpene synthase gene Freesia hybrida Arabidopsis thaliana MYB21 MYC2; Freesia hybrida ; Arabidopsis; MYB–bHLH complex; flower scents; linalool; terpene synthase; transcription factor.

Previously, linalool was found to be the most abundant component among the cocktail of volatiles released from flwers of Freesia hybrida. Linalool formation is catalyzed by monoterpene synthase TPS1. However, the regulatory network developmentally modulating the expression of the TPS1 gene in Freesia hybrida remains unexplored. In this study, three regulatory genes, FhMYB21L1, FhMYB21L2, and FhMYC2, were screened from 52 candidates. Two MYB transcription factor genes were synchronously expressed with FhTPS1 and could activate its expression significantly when overexpressed, and the binding of FhMYB21L2 to the MYBCORE sites in the FhTPS1 promoter was further con firmed, indicating a direct role in activation. FhMYC2 showed an inverse expression pattern compared with FhTPS1; its expression led to a decreased binding of FhMYB21 to the FhTPS1 promoter to reduce its activation capacity when co-expressed, suggesting a role for an MYB-bHLH complex in the regulation of the FhTPS1 gene. In Arabidopsis, both MYB21 and MYC2 regulators were shown to activate the expression of sesquiterpene synthase genes, and the regu latory roles of AtMYB21 and AtMYC2 in the expression of the linalool synthase gene were also confirmed, implying conserved functions of the MYB-bHLH complex in these two evolutionarily divergent plants. Moreover, the expression ratio between MYB21 and MYC2 orthologues might be a determinant factor in floral linalool emission.

Journal of Experimental Botany published new progress about Arabidopsis thaliana. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, SDS of cas: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gawas, Sarita D.; Rathod, Virendra K. published the artcile< Ultrasound assisted green synthesis of 2-ethylhexyl stearate: a cosmetic bio-lubricant>, Computed Properties of 104-76-7, the main research area is 2-ethylhexyl stearate; bio-lubricant; cosmetics; lipase; ultrasound.

The 2-ethylhexyl stearate is used as a bio-lubricant in various cosmetic products. The present study is focused on the biocatalyzed esterification of 2-ethylhexanol and stearic acid to form 2-ethylhexyl stearate catalyzed by Fermase CALB 10000 in the presence of ultrasound treatment. The maximum conversion (95.87%) was obtained at molar ratio of 2-ethylhexanol to stearic acid 2:1, enzyme amount of 2 % (weight/weight), power 80 W, duty cycle 50 % and temperature 50°C in comparatively short reaction time (3 h) in the presence of Fermase as a catalyst. At optimum conditions, it is observed that in the presence of ultrasound; the reaction time minimizes up to 4 h as compared to mech. stirring method (7 h). The physiochem. properties for the 2-ethylhexyl palmitate were also evaluated.

Journal of Oleo Science published new progress about 104-76-7. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Computed Properties of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Doner, Anna C.; Webb, Annabelle R.; Dewey, Nicholas S.; Hartness, Samuel W.; Christianson, Matthew G.; Koritzke, Alanna L.; Larsson, Alexander; Frandsen, Kelsey M.; Rotavera, Brandon published the artcile< Vacuum-ultraviolet absorption cross-sections of functionalized four-carbon species>, Related Products of 627-27-0, the main research area is four carbon species vacuum UV differential absorption spectroscopy.

Absorption cross-sections were measured in the vacuum UV from 5.17 – 9.92 eV using differential absorption spectroscopy for 33 four-carbon species: n-butane, trans-2-butene, cis-2-butene, butanal, butyric acid, ethyloxirane, trans-2,3-dimethyloxirane, cis-2,3-dimethyloxirane, 2-methyloxetane, 2,2′-bioxirane, vinyl oxirane, 3,4-epoxybutan-2-one, diacetyl, di-Et ether, Et vinyl ether, vinyl acetate, acetic anhydride, 1-butanol, 3-buten-1-ol, 1-hydroxy-butan-2-one, 1-hydroxy-butan-3-one, 2,3-epoxybutan-1-ol, 3,4-epoxybutan-1-ol, 2-oxetanemethanol, butanone, Me vinyl ketone, 4H-1,3-dioxine, allyl formate, 2-oxobutanal, 4-hydroxybutanal, 2-methyloxetan-3-one, cis-but-2-en-1-ol, and trans-2-but-enal. Uncertainties were quantified in all cases by accounting for errors in gas-phase concentration, exptl. repeatability, and signal-to-noise ratio as a function of photon energy. With the exception of 2-oxobutanal, which is reported with an uncertainty of 10%, convolving the sources of error using the root-sum-square method led to an upper limit of 5% uncertainty above the detection limit, which is largely attributable to chem. purity. The primary objective of the present work is to provide absolute cross-sections along with quantified uncertainty limits. The majority of the absorption spectra, which reflect electronic transitions such as σ → σ* and n → σ*, are reported for the first time and provide insight into fundamental chem. physics, such as vibrational band structure and Rydberg transitions. The quant. spectra in the present work facilitates the discovery of chem. intermediates that support improvement in the accuracy of computational models for low-temperature combustion and atm. chem.

Journal of Quantitative Spectroscopy & Radiative Transfer published new progress about Absorption spectra. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Related Products of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dull, Ana-Maria; Moga, Marius Alexandru; Dimienescu, Oana Gabriela; Sechel, Gabriela; Burtea, Victoria; Anastasiu, Costin Vlad published the artcile< Therapeutic approaches of resveratrol on endometriosis via anti-inflammatory and anti-angiogenic pathways>, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review endometriosis resveratrol anti inflammation angiogenic therapeutics; anti-inflammatory; cytokines; endometriosis; inflammatory disease; resveratrol.

A review. Endometriosis represents a severe gynecol. pathol., defined by implantation of endometrial glands and stroma outside the uterine cavity. This pathol. affects almost 15% of women during reproductive age and has a wide range of consequences. In affected women, infertility has a 30% rate of prevalence and endometriosis implants increase the risk of ovarian cancer. Despite long periods of studies and investigations, the etiol. and pathogenesis of this disease still remain not fully understood. Initially, endometriosis was related to retrograde menstruation, but new theories have been launched, suggesting that chronic inflammation can influence the development of endometriosis because inflammatory mediators have been identified elevated in patients with endometriosis, specifically in the peritoneal fluid. The importance of dietary phytochems. and their effect on different inflammatory diseases have been highlighted, and nowadays more and more studies are focused on the anal. of nutraceuticals. Resveratrol is a phytoestrogen, a natural polyphenolic compound with antiproliferative and anti-inflammatory actions, found in many dietary sources such as grapes, wine, peanuts, soy, berries, and stilbenes. Resveratrol possesses a significant anti-inflammatory effect via inhibition of prostaglandin synthesis and it has been proved that resveratrol can exhibit apoptosis-inducing activities. From the studies reviewed in this paper, it is clear that the anti-inflammatory effect of this natural compound can contribute to the prevention of endometriosis, this phenolic compound now being considered a new innovative drug in the prevention and treatment of this disease.

Molecules published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Franco, Mario; Sainz, Raquel; Lamsabhi, Al Mokhtar; Diaz, Cristina; Tortosa, Mariola; Cid, M. Belen published the artcile< Evaluation of the role of graphene-based Cu(I) catalysts in borylation reactions>, Application of C4H8O, the main research area is copper monochloride immobilized graphene surface catalyst borylation alkyl halide; alkylboronate preparation borylation alkyl halide monovalent copper graphene catalyst.

Graphene-supported Cu(I) species were prepared by reduction of CuCl2 adsorbed on graphene oxide surface and examined for catalytic performance in alkyl halide borylation with B2pin2, giving alkylboronates. Carbon-supported catalysts have been considered as macromol. ligands which modulate the activity of the metallic catalytic center. Understanding the properties and the factors that control the interactions between the metal and support allows a fine tuning of the catalyzed processes. Although huge effort has been devoted to comprehending binding energies and charge transfer for single atom noble metals, the interaction of graphenic surfaces with cheap and versatile Cu(I) salts has been scarcely studied. A methodical exptl. and theor. anal. of different carbon-based Cu(I) materials in the context of the development of an efficient, general, scalable, and sustainable borylation reaction of aliphatic and aromatic halides has been performed. We have also examined the effect of microwave (MW) radiation in the preparation of these type of materials using sustainable graphite nanoplatelets (GNP) as a support. A detailed anal. of all the possible species in solution revealed that the catalysis is mainly due to an interesting synergetic Cu2O/graphene performance, which has been corroborated by an extensive theor. study. We demonstrated through DFT calculations at a high level of theory that graphene enhances the reactivity of the metal in Cu2O against the halide derivative favoring a radical departure from the halogen. Moreover, this material is able to stabilize radical intermediates providing unexpected pathways not observed using homogeneous Cu(I) catalyzed reactions. Finally, we proved that other common carbon-based supports like carbon black, graphene oxide and reduced graphene oxide provided poorer results in the borylation process.

Catalysis Science & Technology published new progress about Binding energy. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chang, Jun Jie; Pan, Houwen Matthew; Goto, Atsushi published the artcile< Synthesis of vinyl iodide chain-end polymers via organocatalyzed chain-end transformation>, Formula: C9H8O, the main research area is vinyl iodide chain end polymer organocatalyzed transformation.

In the presence of alkynes (CH=C-R2), iodide chain-end polymers (Polymer-I) were successfully transformed to vinyl iodide chain-end polymers (polymer-CH=CR2-I) in a single step via organocatalysis. This reaction is completely metal-free and easy to carry out without using special reagents or special conditions. The polymers encompassing polyacrylates and polymethacrylate, and addnl. functionalities (e.g., OH and CF3) were also incorporated into the R2 moiety. The obtained Polymer-CH=CR2-I further served as a useful precursor for copper-catalyzed cross-coupling reactions with various thiols (R3-SH) to yield vinyl sulfide chain-end polymers (polymer-CH=CR2-SR3) with various R3 moieties. Interestingly, under selected conditions, this organocatalysis also offered block-like copolymers containing a conjugated oligo-alkyne segment and a non-conjugated polyacrylate segment. Exploiting the unique structure, the block-like copolymer was used as an efficient dispersant of carbon nanotubes.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cross-coupling reaction. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Formula: C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Wenxu; Fisher, Paxtyn M.; Vanderloop, Boden H.; Shen, Yun; Shi, Huazhong; Maldonado, Adrian J.; Leaver, David J.; Nes, W. David published the artcile< A nematode sterol C4α-methyltransferase catalyzes a new methylation reaction responsible for sterol diversity>, Application In Synthesis of 434-16-2, the main research area is C4alpha methyltransferase dinosterol Caenorhabditis review; 8(14)-lophenol; Caenorhabditis elegans • biosynthesis; evolution.

A review. Primitive sterol evolution plays an important role in fossil record interpretation and offers potential therapeutic avenues for human disease resulting from nematode infections. Recognizing that C4-Me stenol products [8(14)-lophenol] can be synthesized in bacteria while C4-Me stanol products (dinosterol) can be synthesized in dinoflagellates and preserved as sterane biomarkers in ancient sedimentary rock is key to eukaryotic sterol evolution. In this regard, nematodes have been proposed to convert dietary cholesterol to 8(14)-lophenol by a secondary metabolism pathway that could involve sterol C4 methylation analogous to the C2 methylation of hopanoids (radicle-type mechanism) or C24 methylation of sterols (carbocation-type mechanism). Here, we characterized dichotomous cholesterol metabolic pathways in Caenorhabditis elegans that generate 3-oxo sterol intermediates in sep. paths to lophanol (4-Me stanol) and 8(14)-lophenol (4-Me stenol). We uncovered alternate C3-sterol oxidation and Δ7 desaturation steps that regulate sterol flux from which branching metabolite networks arise, while lophanol/8(14)-lophenol formation is shown to be dependent on a sterol C4α-methyltransferse (4-SMT) that requires 3-oxo sterol substrates and catalyzes a newly discovered 3-keto-enol tautomerism mechanism linked to S-adenosyl-l-methionine-dependent methylation. Alignment-specific substrate-binding domains similarly conserved in 4-SMT and 24-SMT enzymes, despite minimal amino acid sequence identity, suggests divergence from a common, primordial ancestor in the evolution of Me sterols. The combination of these results provides evolutionary leads to sterol diversity and points to cryptic C4-Me steroidogenic pathways of targeted convergence that mediate lineage-specific adaptations.

Journal of Lipid Research published new progress about Caenorhabditis elegans. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Application In Synthesis of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hayek, Simon; Bekaddour, Nassima; Besson, Laurie; Alves de Sousa, Rodolphe; Pietrancosta, Nicolas; Viel, Sebastien; Smith, Nikaia; Jacob, Yves; Nisole, Sebastien; Mandal, Rupasri; Wishart, David S.; Walzer, Thierry; Herbeuval, Jean-Philippe; Vidalain, Pierre-Olivier published the artcile< Identification of Primary Natural Killer Cell Modulators by Chemical Library Screening with a Luciferase-Based Functional Assay>, Electric Literature of 434-16-2, the main research area is innate immunity NK CD8 T cell luciferase myeloid leukemia; dextromethorphan; diphenhydramine; luciferase; natural killer cells; screening.

Natural killer (NK) cells are essential players of the innate immune response that secrete cytolytic factors and cytokines such as IFN-γ when contacting virus-infected or tumor cells. They represent prime targets in immunotherapy as defects in NK cell functions are hallmarks of many pathol. conditions, such as cancer and chronic infections. The functional screening of chem. libraries or biologics would greatly help identify new modulators of NK cell activity, but commonly used methods such as flow cytometry are not easily scalable to high-throughput settings. Here we describe an efficient assay to measure the natural cytotoxicity of primary NK cells where the bioluminescent enzyme NanoLuc is constitutively expressed in the cytoplasm of target cells and is released in co-culture supernatants when lysis occurs. We fully characterized this assay using either purified NK cells or total peripheral blood mononuclear cells (PBMCs), including some patient samples, as effector cells. A pilot screen was also performed on a library of 782 metabolites, xenobiotics, and common drugs, which identified dextrometorphan and diphenhydramine as novel NK cell inhibitors. Finally, this assay was further improved by developing a dual-reporter cell line to simultaneously measure NK cell cytotoxicity and IFN-γ secretion in a single well, extending the potential of this system.

SLAS Discovery published new progress about CD8-positive T cell. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Electric Literature of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Matsuda, Asami; Sato, Fumiya; Yamada, Yasuhiro; Sato, Satoshi published the artcile< Efficient Production of 1,3-Butadiene from 1,4-Butanediol over Yb2O3 Catalyst Prepared through Hydrothermal Aging>, Electric Literature of 627-27-0, the main research area is rare earth metal oxide catalyst butanediol dehydration butadiene.

Vapor-phase catalytic dehydration of 1,4-butanediol (1,4-BDO) was investigated over rare earth metal oxide (RE2O3) catalysts to produce 1,3-butadiene (BD). Among eight RE2O3, Yb2O3 showed the highest catalytic activity to produce BD via an intermediate 3-buten-1-ol (3B1OL). Hydrothermal (HT) aging of precursor precipitate of Yb2O3 greatly enhanced the catalytic activity and the selectivity to 3B1OL of the resulting Yb2O3 catalyst. It was confirmed that the morphol. of Yb2O3 and the catalytic activity varied with the HT conditions. Hydrothermally aged Yb2O3 reduced the formation of propylene, a decomposed product of 3B1OL, even at high temperatures above 400°C. HT-aged Yb2O3 followed by calcination at 700°C showed excellent catalytic activity in the dehydration of 1,4-BDO with the highest BD productivity of 34.6 mol kgcat-1 h-1 and a high BD yield of 97.4% at 450°C.

Bulletin of the Chemical Society of Japan published new progress about Crystallinity. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tierney, Elaine; Remaley, Alan T.; Thurm, Audrey; Jager, Leah R.; Wassif, Christopher A.; Kratz, Lisa E.; Bailey-Wilson, Joan E.; Bukelis, Irena; Sarphare, Geeta; Jung, Eun Sol; Brand, Boudewien; Noah, Kelly K.; Porter, Forbes D. published the artcile< Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits>, Related Products of 434-16-2, the main research area is sterol lipid hypolipidemia apolipoprotein disorder autism adaptive functioning deficit.

An improved understanding of sterol and lipid abnormalities in individuals with autism spectrum disorder (ASD) could lead to personalized treatment approaches. Toward this end, in blood, we identified reduced synthesis of cholesterol in families with ≥2 children with ASD participating with the Autism Genetic Resource Exchange (AGRE), as well as reduced amounts of high-d. lipoprotein cholesterol (HDL), apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB), with 19.9% of the subjects presenting with apolipoprotein patterns similar to hypolipidemic clin. syndromes and 30% with either or both ApoA1 and ApoB less than the fifth centile. Subjects with levels less than the fifth centile of HDL or ApoA1 or ApoA1 + ApoB had lower adaptive functioning than other individuals with ASD, and hypocholesterolemic subjects had apolipoprotein deficits significantly divergent from either typically developing individuals participating in National Institutes of Health or the National Health and Nutrition Examination Survey III.

Translational Psychiatry published new progress about Apolipoprotein A-I Role: ANT (Analyte), ANST (Analytical Study). 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Related Products of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts