Month: October 2022

Mattocks, A. Robin published the artcile< Pyrrolizidine alkaloid analogs. Part 2. Further hydroxymethyl-1-methyl-3-pyrrolines (synthanecines), and the preparation and esterification of some hydroxymethylpyrroles>, Related Products of 52160-51-7, the main research area is synthanecine D E total synthesis; esterification hydroxymethylpyrrole hydroxymethylindole; pyrrolizidine alkaloid analog; pyrrole hydroxymethyl esterification; indole hydroxymethyl esterification; alkylation hydroxymethylpyrrole kinetics.

Synthanecine D and E [I; R = (CH2)2OH, Me] were each prepared in 5 steps from EtO2CCH:CHCH2CO2Et and MeNHCHMeCH2CO2Et, resp. Esters of I [R = (CH2)2OH, Me] behave as analogs of pyrrolizidine alkaloids which can be metabolically dehydrogenated in animals to pyrrole derivatives II [R = (CH2)2OH, Me, R1 = CH2OH, R2 = H] which are monofunctional alkylating agents. The successful esterification of (hydroxymethyl)pyrroles requires rigorous exclusion of moisture and the presence of a tertiary base to prevent polymerization The electrophilic reactivities of 19 (hydroxymethyl)pyrrole and -indole derivatives, including II [R = (CH2)2OH, Me, R1 = CH2OH, R1 = H], towards 4-p-nitrobenzylpyridine are compared. KOH-catalyzed cyclization of EtO2CCH2NMeCH(CH2CO2Et)2, an intermediate in the preparation of I [R = (CH2)2OH], gave 45% II (R = H, R1 = CO2Et, R2 = OH).

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Alkylation kinetics. 52160-51-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H9NO, Related Products of 52160-51-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jarret, Maxime; Abou-Hamdan, Hussein; Kouklovsky, Cyrille; Poupon, Erwan; Evanno, Laurent; Vincent, Guillaume published the artcile< Bioinspired Early Divergent Oxidative Cyclizations toward Pleiocarpamine, Talbotine, and Strictamine>, Synthetic Route of 627-27-0, the main research area is talbotine formal synthesis oxidative cyclization.

Toward the mavacurane and akuammilane monoterpene indole alkaloids, we developed divergent oxidative couplings between the indole nucleus (at N1 or C7) and the C16-malonate of a common tricyclic model related to strictosidine according to a biosynthetic hypothesis postulated by Hesse and Schmid. These oxidative cyclizations led selectively to the formation of the N1-C16 bond of pleiocarpamine or to the C7-C16 bond of strictamine. We were then able to obtain the scaffold I of talbotine.

Organic Letters published new progress about Enantioselective synthesis. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Lianglin; Lin, Shuwei; Li, Yi; Li, Baozong; Yang, Yonggang published the artcile< Ala-Ala dipeptides with a semi-perfluoroalkyl chain: Chirality driven molecular packing difference and self-assembly driven chiral transfer>, Reference of 627-27-0, the main research area is perfluoroalkyl dipeptide synthesis self assembly helical conformation chirality VCD; solid phase peptide synthesis acylation self assembly xerogel nanoribbon; supramol aggregate gelation crystal structure mol packing; mol structure HOMO LUMO perfluoroalkylated dipeptide solubility.

Four Ala-Ala dipeptides with a semi-perfluoroalkyl chain were synthesized. The intermol. hydrogen bonding among amide groups and carboxyl groups as well as the hydrophobic association of semi-perfluoroalkyl chains drove the self-assembly of dipeptides. Homochiral dipeptides were able to self-assemble into coiled nanoribbons in a mixed solvent of DMSO/H2O (5/5, volume/volume), while entangled twisted nanofibers formed for heterochiral ones in a mixed solvent of DMSO/H2O (4/6, volume/volume). The handedness of self-assemblies and the stacking chirality of phenylene groups were controlled by the chirality of the alanine residue at the C-terminal. The vibration CD investigation indicated that the helicity of the semi-perfluoroalkyl chain was controlled by the handedness of dipeptide self-assemblies. The X-ray diffraction study showed that homochiral and heterochiral dipeptides underwent distinct mol. packing during the self-assembly. Our results clearly demonstrated that, through supramol. self-assembly, the chirality transferred from the amino acid building block to the self-assemblies and eventually to the semi-perfluoroalkyl chain.

New Journal of Chemistry published new progress about Acylation. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Reference of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mulkapuri, Sateesh; Kurapati, Sathish Kumar; Das, Samar K. published the artcile< Carbonate encapsulation from dissolved atmospheric CO2 into a polyoxovanadate capsule>, Application In Synthesis of 76-84-6, the main research area is sodium polyoxovanadate carbonate chloride complex preparation encapsulation magnetic property; thermal stability sodium polyoxovanadate carbonate chloride; crystal structure sodium polyoxovanadate carbonate chloride.

An aqueous synthesis, involving the reduction of the VO3- anion in a mild alk. pH in the presence of α-Bi2O3, led to the formation of a fully reduced polyoxovanadate (POV) capsule, with CO32- anion encapsulation in its internal cavity, in the compound [Na6(H2O)24][H8VIV15O36(CO3)]·3N2H4·10H2O (1). This CO32- anion encapsulation, the source of which is absorbed aerial CO2 in the pertinent aqueous alk. reaction mixture, occurs only in the presence of α-Bi2O3. Compound 1 crystals, upon exposure to HCl acid vapor, exclude CO2 gas that can react with the Grignard reagent (PhMgBr) to form triphenylcarbinol and benzoic acid; during this solid-vapor interface reaction, compound 1 itself transforms into an amorphous material that includes the Cl- anion but could not be characterized unambiguously. Thus, we have synthesized a chloride ion (Cl-) encapsulated compound [Na10(H2O)24][H3VIV15O36(Cl)]·6H2O (2) in a direct synthesis protocol, which has been characterized by crystallog. as well as by other spectroscopic methods. Compounds 1 and 2, each having fifteen vanadium(IV) centers, exhibit interesting magnetism in their solid states. The temperature-dependent magnetic susceptibilities for compounds 1 and 2 have been recordred at 0.1 T at of 3-300 K. The temperature-dependent magnetic susceptibilities of compounds 1 and 2 are shown in the form of χM vs.T and their product χMT vs.T plots.

Dalton Transactions published new progress about Crystal structure. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Application In Synthesis of 76-84-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jin, Xiaoxia; Wei, Yingze; Liu, Yushan; Lu, Xiaoyun; Ding, Fei; Wang, Jiatai; Yang, Shuyun published the artcile< Resveratrol promotes sensitization to Doxorubicin by inhibiting epithelial-mesenchymal transition and modulating SIRT1/β-catenin signaling pathway in breast cancer>, SDS of cas: 501-36-0 , the main research area is breast cancer epithelial mesenchymal transition SIRT1 signaling; Doxorubicin; Drug resistance; EMT; SIRT1; breast cancer; resveratrol; β-catenin.

Breast cancer is one of the leading fatal diseases for women worldwide who cannot have surgery typically have to rely on systemic chemotherapy to extend their survival. Doxorubicin (DOX) is one of the most commonly used chemotherapeutic agents against breast cancer, but acquired resistance to DOX can seriously impede the efficacy of chemotherapy, leading to poor prognosis and recurrences of cancer. Resveratrol (RES) is a phytoalexin with pharmacol. antitumor properties, but its underlying mechanisms are not clearly understood in the treatment of DOX-resistant breast cancer. We used cell viability assays, cell scratch tests, and transwell assays combined with Western blotting and immunofluorescent staining to evaluate the effects of RES on chemoresistance and the epithelial-mesenchymal transitions (EMTs) in adriamycin-resistant MCF7/ADR breast cancer cells, and to investigate its underlying mechanisms. The results showed that a treatment of RES combining with DOX effectively inhibited cell growth, suppressed cell migration, and promoted cell apoptosis. RES reversed EMT properties of MCF7/ADR cells by modulating the connection between SIRT1 and β-catenin, which provides a hopeful therapeutic avenue to conquer DOX-resistance and thereby prolong survival rates in breast cancer patients.

Cancer Medicine published new progress about Apoptosis. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cho, Soon Ok; Lim, Joo Weon; Kim, Hyeyoung published the artcile< Oxidative stress induces apoptosis via calpain- and caspase-3-mediated cleavage of ATM in pancreatic acinar cells>, HPLC of Formula: 492-62-6, the main research area is calpain caspase ATM pancreatic acinar cell oxidative stress apoptosis; Ataxia telangiectasia mutated; calpain; caspase-3; glucose/glucose oxidase; pancreatic acinar cells.

Oxidative stress-induced DNA cleavage and apoptosis in pancreatic acinar cells has been implicated in the pathogenesis of acute pancreatitis. Thus, an efficient DNA repair process is key to prevention of apoptotic pancreatic acinar cell death. Ataxia telangiectasia mutated (ATM), a sensor of DNA breaks, functions by recruiting DNA repair proteins to initiate the DNA repair process. In the present study, we investigated whether H2O2 produced by the action of glucose oxidase on α-D-glucose (G/GO) induces apoptosis in pancreatic acinar AR42J cells through an alteration of the level of ATM. As a result, G/GO induced apoptosis by promoting a loss of cell viability, increase in Bax, decrease in Bcl-2, cleavage of poly (ADP-ribose) polymerase (PARP) and fragmentation of DNA. In addition, ATM cleavage along with elevated levels of calpain and caspase-3 activity was induced by G/GO. By using ATM siRNA, we demonstrated that reduction in ATM levels enhanced G/GO-induced apoptosis. Moreover, inhibition of calpain activity by calpeptin or calpastatin, or by inhibition of caspase-3 with z-DEVD, suppressed G/GO-induced apoptosis and ATM cleavage. Collectively, these findings suggest that proteolysis of ATM is the underlying mechanism of apoptosis of pancreatic acinar cells caused by exposure to oxidative stress.

Free Radical Research published new progress about Actins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, HPLC of Formula: 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Capell-Hattam, Isabelle M.; Sharpe, Laura J.; Qian, Lydia; Hart-Smith, Gene; Prabhu, Anika V.; Brown, Andrew J. published the artcile< Twin enzymes, divergent control: the cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally>, Safety of (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is human cholesterol biosynthesis enzyme DHCR14 LBR post translational regulation; dehydrocholesterol reductase DHCR14 human regulation lamin B receptor LBR; DHCR14; LBR; TM7SF2; cholesterol; cholesterol regulation; endoplasmic reticulum-associated protein degradation (ERAD); enzyme degradation; protein degradation.

Cholesterol synthesis is a tightly regulated process, both transcriptionally and post-translationally. Transcriptional control of cholesterol synthesis is relatively well-understood. However, of the ~20 enzymes in cholesterol biosynthesis, post-translational regulation has only been examined for a small number Three of the four sterol reductases in cholesterol production, 7-dehydrocholesterol reductase (DHCR7), 14-dehydrocholesterol reductase (DHCR14), and lamin-B receptor (LBR), share evolutionary ties with a high level of sequence homol. and predicted structural homol. DHCR14 and LBR uniquely share the same Δ-14 reductase activity in cholesterol biosynthesis, yet little is known about their post-translational regulation. We have previously identified specific modes of post-translational control of DHCR7, but it is unknown whether these regulatory mechanisms are shared by DHCR14 and LBR. Using CHO-7 cells stably expressing epitope-tagged DHCR14 or LBR, we investigated the post-translational regulation of these enzymes. We found that DHCR14 and LBR undergo differential post-translational regulation, with DHCR14 being rapidly turned over, triggered by cholesterol and other sterol intermediates, whereas LBR remained stable. DHCR14 is degraded via the ubiquitin-proteasome system, and we identified several DHCR14 and DHCR7 putative interaction partners, including a number of E3 ligases that modulate DHCR14 levels. Interestingly, we found that gene expression across an array of human tissues showed a neg. relationship between the C14-sterol reductases; one enzyme or the other tends to be predominantly expressed in each tissue. Overall, our findings indicate that whereas LBR tends to be the constitutively active C14-sterol reductase, DHCR14 levels are tunable, responding to the local cellular demands for cholesterol.

Journal of Biological Chemistry published new progress about Follicular fluid. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Safety of (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ibert, Quentin; Cauwel, Madeleine; Glachet, Thomas; Tite, Tony; Le Nahenec-Martel, Patricia; Lohier, Jean-Francois; Renard, Pierre-Yves; Franck, Xavier; Reboul, Vincent; Sabot, Cyrille published the artcile< One-Pot Synthesis of Diazirines and 15N2-Diazirines from Ketones, Aldehydes and Derivatives: Development and Mechanistic Insight>, COA of Formula: C4H8N2O, the main research area is ketone aldehyde imine ammonia butyl hypochlorite phenyliodine diacetate cyclization; diazirine one pot preparation.

Broad scope one-pot diazirine synthesis strategies have been developed using two different oxidants depending on the nature of the starting material. In all cases, an inexpensive com. solution of ammonia (NH3) in methanol (MeOH) was employed, avoiding the difficult use of liquid ammonia. With aliphatic ketones, t-Bu hypochlorite (t-BuOCl) was found to be the best oxidant whereas it is preferable to use phenyliodine diacetate (PIDA) with aromatic ketones, aldehydes and imines. The nature of the imine-protecting group is essential and only t-Bu imine allowed the synthesis of 15N2-diazirine with complete 15N incorporation, emphasizing a key trans-imination step in the reaction mechanism. These methods are operationally simple, and tolerant to most functional groups, providing diazirines with yields ranging from 20 to 99%.

Advanced Synthesis & Catalysis published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, COA of Formula: C4H8N2O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

De Rossi, Charles; Bambino, Kathryn; Morrison, Joshua; Sakarin, Isabel; Villacorta-Martin, Carlos; Zhang, Changwen; Ellis, Jillian L.; Fiel, M. Isabel; Ybanez, Maria; Lee, Youngmin A.; Huang, Kuan-lin; Yin, Chunyue; Sakaguchi, Takuya F.; Friedman, Scott L.; Villanueva, Augusto; Chu, Jaime published the artcile< Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans>, Product Details of C6H12O6, the main research area is fibrosis hepatic stellate cell mannose phosphate isomerase.

The growing burden of liver fibrosis and lack of effective antifibrotic therapies highlight the need for identification of pathways and complementary model systems of hepatic fibrosis. A rare, monogenic disorder in which children with mutations in mannose phosphate isomerase (MPI) develop liver fibrosis led us to explore the function of MPI and mannose metabolism in liver development and adult liver diseases. Herein, analyses of transcriptomic data from three human liver cohorts demonstrate that MPI gene expression is down-regulated proportionate to fibrosis in chronic liver diseases, including nonalcoholic fatty liver disease and hepatitis B virus. Depletion of MPI in zebrafish liver in vivo and in human hepatic stellate cell (HSC) lines in culture activates fibrotic responses, indicating that loss of MPI promotes HSC activation. We further demonstrate that mannose supplementation can attenuate HSC activation, leading to reduced fibrogenic activation in zebrafish, culture-activated HSCs, and in ethanol-activated HSCs. Conclusion: These data indicate the prospect that modulation of mannose metabolism pathways could reduce HSC activation and improve hepatic fibrosis.

Hepatology (Hoboken, NJ, United States) published new progress about Animal gene, COL1A1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kiskova, Terezia; Kubatka, Peter; Busselberg, Dietrich; Kassayova, Monika published the artcile< The plant-derived compound resveratrol in brain cancer: a review>, Related Products of 501-36-0 , the main research area is review brain cancer resveratrol; brain cancer; drug resistance; glioblastoma; resveratrol.

A review. Despite intensive research, malignant brain tumors are among the most difficult to treat due to high resistance to conventional therapeutic approaches. High-grade malignant gliomas, including glioblastoma and anaplastic astrocytoma, are among the most devastating and rapidly growing cancers. Despite the ability of standard treatment agents to achieve therapeutic concentrations in the brain, malignant gliomas are often resistant to alkylating agents. Resveratrol is a plant polyphenol occurring in nuts, berries, grapes, and red wine. Resveratrol crosses the blood-brain barrier and may influence the central nervous system. Moreover, it influences the enzyme isocitrate dehydrogenase and, more importantly, the resistance to standard treatment via various mechanisms, such as O6-methylguanine methyltransferase. This review summarizes the anticancer effects of resveratrol in various types of brain cancer. Several in vitro and in vivo studies have presented promising results; however, further clin. research is necessary to prove the therapeutic efficacy of resveratrol in brain cancer treatment.

Biomolecules published new progress about Astrocytoma. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Related Products of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts