Month: October 2022

Zhou, Lin; Lu, Runxin; Liu, Qijun; Xiao, Bin; Hai, Li; Guo, Li; Wu, Yong; Zheng, Yongxiang published an article on February 28 ,2021. The article was titled 《Two branched fructose modification improves tumor targeting delivery of liposomes to breast cancer in intro and in vivo》, and you may find the article in Journal of Drug Delivery Science and Technology.Formula: C12H20O6 The information in the text is summarized as follows:

Breast cancer is the leading cause of cancer death for females and needs more specific treatments. D-fructose is a promising ligand targeting to glucose transporter 5 (GLUT5) on breast cancer cells, and single-branched fructose has been used for targeting nanoparticles. However, the impact of two-branched fructose on targeting delivery remains to be elucidated. In this study, we synthesized a two-branched fructose ligand, prepared fructose-decorating liposomes and evaluated them in vitro and in vivo. The results showed liposomes were approx. 102 nm-107 nm in size, with -3.19 mV to -3.61 mV zeta potential, and their encapsulation efficiency of paclitaxel (PTX) were 87% ∼ 91%. The liposomes decorated with two-branched fructose (Fru2-Lip) had the highest cellular uptake and cytotoxicity in 4T1 cells and MCF7 cells in vitro, and the strongest in vivo targeting delivery and accumulation in breast tumor sites, even compared with the liposomes decorated with two equivalent fructose. Further investigation of the mechanism underlying the increased targeting released the two-branched fructose had a 7.93 kcal/mol higher binding free energy to GLUT5, compared with the single-branched fructose. These results illustrated the two-branched fructose can significantly enhance the tumor-targeting of liposomes and supported the application of multi-branched ligands for the design of tumor-specific targeting delivery system. The experimental process involved the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Formula: C12H20O6)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Formula: C12H20O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,El Awamy, Moustafa; Mohammad, Haroon; Hussien, Abdelrahman; Abutaleb, Nader S.; Hagras, Mohamed; Serya, Rabah A. T.; Taher, Azza T.; Abouzid, Khaled A. M.; Seleem, Mohamed N.; Mayhoub, Abdelrahman S. published 《Alkoxyphenylthiazoles with broad-spectrum activity against multidrug-resistant gram-positive bacterial pathogens》.European Journal of Medicinal Chemistry published the findings.Product Details of 18621-18-6 The information in the text is summarized as follows:

With the continued rise of antibiotic resistance and reduced susceptibility to almost all front-line antibiotics, multidrug-resistant Gram-pos. bacterial infections represent an incessant threat to healthcare providers. This study presents a new series of phenylthiazole compounds where two active moieties were combined into one scaffold. The antibacterial activity of the hybrid structures extended to include several clin.-relevant multi-drug resistant pathogens including methicillin-resistant and vancomycin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, vancomycin-resistant enterococci, cephalosporin-resistant and methicillin-resistant Streptococcus pneumoniae, and Listeria monocytogenes. In addition, the most potent compounds, 16a and 17a, exhibited a fast bactericidal mode of action in vitro with low susceptibility to induce bacterial resistance. In addition to its potent spectrum of activity against Gram-pos. bacterial pathogens, compound 17a was found to be metabolically stable in rats, with a half-life of 4h. In the experimental materials used by the author, we found Azetidin-3-ol hydrochloride(cas: 18621-18-6Product Details of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Saitou, M. published 《Cu-Zr thin film electrodeposited from an aqueous solution using rectangular pulse current over a megahertz frequency range》.International Journal of Electrochemical Science published the findings.Recommanded Product: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate The information in the text is summarized as follows:

Cu-Zr thin films electrodeposited on indium tin oxide glasses from aq solns contg potassium sodium tartrate tetrahydrate using rectangular pulse current over a frequency range of 0.5- 1.4 MHz were investigated. Resonant frequencies at which the Zr content in the Cu-Zr thin films was max were identified using energy dispersive X-ray spectroscopy. A resonant frequency interval between the neighboring resonant frequencies was 0.26 MHz on average The resonant frequencies and resonant frequency interval were explained in terms of an energy level transition between the Fermi energy level of electron in the indium tin oxide and quantized rotational energy level of a complex ion comprising Zr and tartaric ions in the aq solution X-ray diffraction anal confirmed that the Cu-Zr thin film was an alloy composed of Cu and Zr. Surface images of the Cu-Zr thin film obsd using SEM indicated an aggregation of cauliflower-like islands consisting of nano-scale grains. In the experimental materials used by the author, we found Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Recommanded Product: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Recommanded Product: Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate As a Biuret reagent, it is used to measure the protein concentration. Furthermore, it is used as laxative and is also used in food industry.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Danon, Jonathan J.; Leigh, David A.; Pisano, Simone; Valero, Alberto; Vitorica-Yrezabal, Inigo J. published 《A Six-Crossing Doubly Interlocked [2]Catenane with Twisted Rings, and a Molecular Granny Knot》.Angewandte Chemie, International Edition published the findings.Safety of 2,6-Pyridinedimethanol The information in the text is summarized as follows:

A mol. 623 link (a six crossing, doubly interlocked, [2]catenane with twisted rings) and a 31#31 granny knot (a composite knot made up of two trefoil tangles of the same handedness) were constructed by ring-closing olefin metathesis of an Fe(II)-coordinated 2×2 interwoven grid. The connections were directed by pendant Ph groups to be between proximal ligand ends on the same faces of the grid. The 623 link was separated from the topoisomeric granny knot by recycling size-exclusion chromatog. The identity of each topoisomer was determined by tandem mass spectrometry and the structure of the 623 link confirmed by x-ray crystallog., which revealed two 82-membered macrocycles, each in figure-of-eight conformations, linked through both pairs of loops. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Safety of 2,6-Pyridinedimethanol) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Safety of 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Journal of the American Chemical Society included an article by Smith, Russell T.; Zhang, Xiaheng; Rincon, Juan A.; Agejas, Javier; Mateos, Carlos; Barberis, Mario; Garcia-Cerrada, Susana; de Frutos, Oscar; MacMillan, David W. C.. Computed Properties of C3H8ClNO. The article was titled 《Metallaphotoredox-Catalyzed Cross-Electrophile Csp3-Csp3 Coupling of Aliphatic Bromides》. The information in the text is summarized as follows:

A strategy for the installation of small alkyl fragments onto pharmaceutically relevant aliphatic structures has been established via metallaphotoredox catalysis. Herein, we report that tris(trimethylsilyl)silanol can be employed as an effective halogen abstraction reagent that, in combination with photoredox and nickel catalysis, allows a generic approach to Csp3-Csp3 cross-electrophile coupling. In this study, we demonstrate that a variety of aliphatic drug-like groups can be successfully coupled with a number of com. available small alkyl electrophiles, including Me tosylate and strained cyclic alkyl bromides. Moreover, the union of two secondary aliphatic carbon centers, a long-standing challenge for organic mol. construction, has been accomplished with a wide array of structural formats. Last, this technol. can be selectively merged with Csp2-Csp3 aryl-alkyl couplings to build drug-like systems in a highly modular fashion. The experimental part of the paper was very detailed, including the reaction process of Azetidin-3-ol hydrochloride(cas: 18621-18-6Computed Properties of C3H8ClNO)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Computed Properties of C3H8ClNO Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of the American Chemical Society included an article by Bregante, Daniel T.; Johnson, Alayna M.; Patel, Ami Y.; Ayla, E. Zeynep; Cordon, Michael J.; Bukowski, Brandon C.; Greeley, Jeffrey; Gounder, Rajamani; Flaherty, David W.. Computed Properties of C6H12O. The article was titled 《Cooperative Effects between Hydrophilic Pores and Solvents: Catalytic Consequences of Hydrogen Bonding on Alkene Epoxidation in Zeolites》. The information in the text is summarized as follows:

Hydrophobic voids within titanium silicates have long been considered necessary to achieve high rates and selectivities for alkene epoxidations with H2O2. The catalytic consequences of silanol groups and their stabilization of hydrogen-bonded networks of water (H2O), however, have not been demonstrated in ways that lead to a clear understanding of their importance. We compare turnover rates for 1-octene epoxidation and H2O2 decomposition over a series of Ti-substituted zeolite *BEA (Ti-BEA) that encompasses a wide range of densities of silanol nests ((SiOH)4). The most hydrophilic Ti-BEA gives epoxidation turnover rates that are 100 times larger than those in defect-free Ti-BEA, yet rates of H2O2 decomposition are similar for all (SiOH)4 densities. These differences cause the most hydrophilic Ti-BEA to also give the highest selectivities, which defies conventional wisdom. Spectroscopic, thermodn., and kinetic evidence indicate that these catalytic differences are not due to changes in the electronic affinity of the active site, the electronic structure of Ti-OOH intermediates, or the mechanism for epoxidation Comparisons of apparent activation enthalpies and entropies show that differences in epoxidation rates and selectivities reflect favorable entropy gains produced when epoxidation transition states disrupt hydrogen-bonded H2O clusters anchored to (SiOH)4 near active sites. Transition states for H2O2 decomposition hydrogen bond with H2O in ways similar to Ti-OOH reactive species, such that decomposition becomes insensitive to the presence of (SiOH)4. Collectively, these findings clarify how mol. interactions between reactive species, hydrogen-bonded solvent networks, and polar surfaces can influence rates and selectivities for epoxidation (and other reactions) in zeolite catalysts. In addition to this study using 5-Hexen-1-ol, there are many other studies that have used 5-Hexen-1-ol(cas: 821-41-0Computed Properties of C6H12O) was used in this study.

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Computed Properties of C6H12O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Environmental Science and Pollution Research included an article by Lin, Xianglong; Sun, Zaijin; Zhao, Long; Fan, Feiyue; Ma, Jin; Zhao, Shutingi; Hou, Hong. SDS of cas: 6381-59-5. The article was titled 《Toxicity of exogenous antimony to the soil-dwelling springtail Folsomia candida》. The information in the text is summarized as follows:

Antimony (Sb) is a toxic pollutant, but data for Sb toxicity to springtails in soil are limited, and the effects of Sb speciation, soil physiochem. properties, and aging time on Sb toxicity have not been investigated. To address this, the effects of Sb on Folsomia candida were evaluated in laboratory studies. The results demonstrated that compared with Sb(III), no significant change in mortality was observed in Sb(V)-treated soil, but the EC50 value for the reproduction was 28-fold higher than that of Sb(III). Sb(III) toxicity was very different in four soils. The LC50 values for the survival were 2325-5107 mg kg-1 in the acute test and 605-2682 mg kg-1 in the chronic test, and the EC50 values for the reproduction were 293-2317 mg kg-1. The toxicity discrepancies were associated with the variations in oxidation potential and sorption capacity among corresponding soils. Toxicity significantly pos. correlated with the clay and amorphous iron content but significantly neg. correlated with pH. Long-term aging markedly decreased Sb(III) toxicity, and the EC50 and LC50 values were unexpectedly higher than the highest test concentration in soil aged for 180 days. Sb(III) toxicity was probably modified more by oxidation than by changes in the available Sb fraction during aging.Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5SDS of cas: 6381-59-5) was used in this study.

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. SDS of cas: 6381-59-5 It may be used as a constituent to prepare DNS (3,5- dinitrosalicylic acid) reagent and Fehling′s solution B, which are used in the determination of reducing sugar.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,European Journal of Pharmaceutical Sciences included an article by Debnath, Utsab; Mukherjee, Suprabhat; Joardar, Nikhilesh; Sinha Babu, Santi P.; Jana, Kuladip; Misra, Anup Kumar. Electric Literature of C7H6O3. The article was titled 《Aryl quinolinyl hydrazone derivatives as anti-inflammatory agents that inhibit TLR4 activation in the macrophages》. The information in the text is summarized as follows:

A series of aryl 7-chloroquinolinyl hydrazone derivatives (3a-u) have been synthesized in 55-76% yield using simple reaction condition. The synthesized compounds were evaluated for their anti-inflammatory activities based on their ability to inhibit pro-inflammatory cytokine secretion from the macrophages after stimulation with lipopolysaccharide (LPS). Three compounds appeared as promising anti-inflammatory agents. The mechanism of inflammatory activity of the potent compound 3e was further investigated using a series of biochem., mol. and microscopic techniques. Further structure activity relationship (SAR) study was carried out to validate the anti-inflammatory activities of the active compounds Our exptl. data revealed that the active moiety i.e. compound 3e majorly causes inhibition of TLR4 signaling pathway and this appears to be the novel functional attribute of this compound In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Electric Literature of C7H6O3) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Electric Literature of C7H6O3

Referemce:
Alcohol – Wikipedia,
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In 2019,European Journal of Inorganic Chemistry included an article by Buchner, Magnus R.; Mueller, Matthias; Raymond, Onyekachi; Severinsen, Rebecca J.; Nixon, David J.; Henderson, William; Brothers, Penelope J.; Rowlands, Gareth J.; Plieger, Paul G.. COA of Formula: C6H7BO3. The article was titled 《Synthesis of a Boronic Acid Anhydride Based Ligand and Its Application in Beryllium Coordination》. The information in the text is summarized as follows:

The synthesis of a boronic acid anhydride-based ligand containing one three- and one four-coordinated B atom is presented. This ligand was successfully employed as a tridentate κ1N,κ2O-ligand in the coordination of Be chloride and both the ligand and the resulting complex were structurally characterized. While the B-element separations are within the typical range of related homo-nuclear compounds, the corresponding Be-element distances are rather long, suggesting unexpectedly high electron d. at the Be center. Incorporation of a Be atom in a six-membered ring causes no more distortion than the corresponding B atom, suggesting that analogous ligand systems could be used in B and Be coordination chem. The generated hetero-tri-nuclear complex enables the direct comparison of bond lengths and angles at Be and B atoms in similar coordination environments and can act as a monomol. model for Be borates. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxyphenylboronic acid(cas: 89466-08-0COA of Formula: C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. COA of Formula: C6H7BO3

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The author of 《Heavy atom labeling enables silanol defect visualization in silicalite-1 crystals》 were Li, Teng; Krumeich, Frank; Ihli, Johannes; Ma, Zhiqiang; Ishikawa, Takashi; Pinar, Ana B.; van Bokhoven, Jeroen A.. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Safety of 3-Aminopropan-1-ol The author mentioned the following in the article:

Using heavy-atom labeling in conjunction with electron microscopy, the authors here visualize the distribution of point defects, i.e. internal silanol groups, in silicalite-1 zeolites at the single crystal level. In addition to this study using 3-Aminopropan-1-ol, there are many other studies that have used 3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Safety of 3-Aminopropan-1-ol

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Alcohol – Wikipedia,
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