Month: October 2022

《Iron-Catalyzed C-H Borylation of Arenes》 was written by Dombray, Thomas; Werncke, C. Gunnar; Jiang, Shi; Grellier, Mary; Vendier, Laure; Bontemps, Sebastien; Sortais, Jean-Baptiste; Sabo-Etienne, Sylviane; Darcel, Christophe. Related Products of 401797-00-0 And the article was included in Journal of the American Chemical Society on April 1 ,2015. The article conveys some information:

Well-defined iron bis(diphosphine) complexes are active catalysts for the dehydrogenative C-H borylation of aromatic and heteroaromatic derivatives with pinacolborane. The corresponding borylated compounds were isolated in moderate to good yields (25-73%) with a 5 mol% catalyst loading under UV irradiation (350 nm) at room temperature Stoichiometric reactivity studies and isolation of an original trans-hydrido(boryl)iron complex, Fe(H)(Bpin)(dmpe)2, allowed us to propose a mechanism showing the role of some key catalytic species. In addition to this study using 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, there are many other studies that have used 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Related Products of 401797-00-0) was used in this study.

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy groups participate in the dehydration reactions that link simple biological molecules into long chains. The joining of a fatty acid to glycerol to form a triacylglycerol removes the −OH from the carboxy end of the fatty acid.Related Products of 401797-00-0

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Alcohol – Wikipedia,
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《Molecular structure of cefuroxime axetil complexes with α-, β-, γ-, and 2-hydroxypropyl-β-cyclodextrins: molecular simulations and Raman spectroscopic and imaging studies》 was published in International Journal of Molecular Sciences in 2021. These research results belong to Gieroba, Barbara; Kalisz, Grzegorz; Sroka-Bartnicka, Anna; Plazinska, Anita; Plazinski, Wojciech; Starek, Malgorzata; Dabrowska, Monika. HPLC of Formula: 54-17-1 The article mentions the following:

The formation of cefuroxime axetil + cyclodextrin (CA + CD) complexes increases the aqueous solubility of CA, improves its physico-chem. properties, and facilitates a biomembrane-mediated drug delivery process. In CD-based tablet formulations, it is crucial to investigate the mol. details of complexes in final pharmaceutical preparation In this study, Raman spectroscopy and mapping were applied for the detection and identification of chem. groups involved in α-, β-, γ-, and 2-hydroxypropyl-β-CD (2-HP- β-CD) + CA complexation process. The exptl. studies have been complemented by mol. dynamics-based investigations, providing addnl. mol. details of CA + CD interactions. It has been demonstrated that CA forms the guest-host type inclusion complexes with all studied CDs; however, the nature of the interactions is slightly different. It seems that both α- and β-CD interact with furanyl and methoxy moieties of CA, γ-CD forms a more diverse pattern of interactions with CA, which are not observed in other CDs, whereas 2HP-β-CD binds CA with the contribution of hydrogen bonding. Apart from supporting this interpretation of the exptl. data, mol. dynamics simulations allowed for ordering the CA + CD binding affinities. The obtained results proved that the mol. details of the host-guest complexation can be successfully predicted from the combination of Raman spectroscopy and mol. modeling. The results came from multiple reactions, including the reaction of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1HPLC of Formula: 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.HPLC of Formula: 54-17-1

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《Mono-Phosphine Metal-Organic Framework-Supported Cobalt Catalyst for Efficient Borylation Reactions》 was written by Newar, Rajashree; Begum, Wahida; Akhtar, Naved; Antil, Neha; Chauhan, Manav; Kumar, Ajay; Gupta, Poorvi; Malik, Jaideep; Balendra; Manna, Kuntal. Quality Control of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane And the article was included in European Journal of Inorganic Chemistry on April 8 ,2022. The article conveys some information:

The authors report a metal-organic framework (MOF) supported monoligated phosphine-Co complex, which is an active heterogeneous catalyst for aromatic C-H borylation and alkene hydroboration. The mono(phosphine)-Co catalyst (MOF-P-Co) was prepared by metalation of a porous triarylphosphine-functionalized MOF (MOF-P) with CoCl2 followed by activation with NaEt3BH. The MOF catalyst has a broad substrate scope with excellent functional group tolerance to afford arene- and alkyl-boronate esters in excellent yields and selectivity. MOF-P-Co gave a turnover number (TON) of 30,000 and could be recycled and reused at least 13 times in arene C-H borylation. Importantly, the attempt to prepare the homogeneous control (Ph3P-Co) using PPh3 was unsuccessful due to the facile disproportionation reactions or intermol. ligand exchanges in the solution In contrast, the site isolation of the active mono(phosphine)-Co species within the MOF affords the robust and coordinatively unsaturated metal complexes, allowing to explore their catalytic properties and the reaction mechanism. In the experiment, the researchers used 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Quality Control of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Quality Control of 2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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《Vinylidenation of Organoboronic Esters Enabled by a Pd-Catalyzed Metallate Shift》 was written by Aparece, Mark D.; Gao, Chenpeng; Lovinger, Gabriel J.; Morken, James P.. COA of Formula: C12H17BO2This research focused onvinylidenation organoboronic ester palladium catalyzed metalate shift; disubstituted alkenyl boronic ester preparation vinyl insertion reaction; allyl complexes; boron; homogeneous catalysis; palladium. The article conveys some information:

Organoboron “”ate”” complexes undergo a net vinyl insertion reaction to give 1,1-disubstituted alkenyl boronic esters when treated with stoichiometric allyl acetate and a palladium catalyst. Reactions that employ vinyllithium afforded good to excellent yields after one hour, while reactions that employ vinylmagnesium chloride furnished modest to good yields after 18 h. In the experiment, the researchers used many compounds, for example, 4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6COA of Formula: C12H17BO2)

4,4,5,5-Tetramethyl-2-phenyl-1,3,2-dioxaborolane(cas: 24388-23-6) also known as boronate ester, is generally used in metal-catalyzed C-C bond formation reactions like Suzuki–Miyaura reaction.COA of Formula: C12H17BO2

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Alcohol – Wikipedia,
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Quality Control of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochlorideOn November 30, 2019 ,《Characterization of crosslinked hard gelatin capsules for a structural assembly of elementary osmotic pump delivery system》 appeared in Journal of Pharmaceutical Investigation. The author of the article were Monton, Chaowalit; Kulvanich, Poj. The article conveys some information:

The objective of this study was to characterize the crosslinked hard gelatin capsules (HGCs) for use as a structural assembly of elementary osmotic pumps (EOP). HGCs were crosslinked in formaldehyde vapor for 6, 12, and 24 h. Weight loss after immersing in various mediums, water soluble protein fraction, loss on drying, and formaldehyde residue were investigated. Fourier transform IR (FTIR) spectra were used to detect the crosslinking formation. The EOP capsules were prepared for delivery of diltiazem hydrochloride (DIL HCl) and ambroxol hydrochloride (AMB HCl), which are freely and sparingly water soluble drugs, resp. Physicochem. stability of storage crosslinked HGC shells was investigated. All crosslinked HGC shells were water insoluble FTIR spectra exhibited intermediate lysine methylol and arginine methylol peaks. Storage time increased, moisture content increased and formaldehyde residue decreased. The developing EOP capsules were more appropriate for delivery of high water soluble rather than low water soluble drug. EOP capsule contained 100 mg DIL HCl using HGCs crosslinked for 12 h provided release profiles for 12 h with a lag time of 2.6-3.1 h. It was also found that DIL HCl EOP capsules prepared using crosslinked HGC shells stored for 90 days maintained the similar drug release profiles. AMB HCl EOP capsules exhibited low drug release. In summary, the crosslinked HGCs were applicable as a structural assembly of the osmotic controlled drug delivery system. In the experiment, the researchers used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Quality Control of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Quality Control of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Computed Properties of C13H19Br2ClN2OOn May 31, 2019, Wang, Dongmei; Sun, Shu; Hu, Songxue published an article in Pakistan Journal of Pharmaceutical Sciences. The article was 《The therapeutic efficacy of high-dose ambroxol and the nursing effects in the treatment of severe pneumonia》. The article mentions the following:

To observe and analyze the therapeutic efficacy of high-dose ambroxol in the treatment of severe pneumonia, as well as summarize the nursing methods. A total of 180 patients diagnosed with severe pneumonia and treated at our hospital who were enrolled. The patients were divided into a control group and are search group, with 90 patients in each group. Of those, patients in the research group were treated with high-doses ambroxol, while small-dose ambroxol was administered to patients in the control group. The therapeutic efficacy was compared between both groups. Meanwhile, predictive nursing regimens were applied on patients in the research group, while routine nursing care was given to patients in the control group. The nursing satisfaction was compared between both groups. By comparing the pulmonary function indicators, Comparison of procalcitonin (PCT) and C-reactive protein (CRP) results showed that all indicators of the research group were obviously better than those of the control group (p<0.05). The time of infection control, ICU stay and hospital stay of the research group were significantly less than those of the control group (p<0.05). Moreover, the overall nursing satisfaction of the research group was significantly higher than that of the control group (p<0.05).Application of high-dose ambroxol and scientific nursing methods could significantly improve the therapeutic efficacy in the treatment of severe pneumonia and gain favorable nursing satisfaction. The experimental part of the paper was very detailed, including the reaction process of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Computed Properties of C13H19Br2ClN2O)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Computed Properties of C13H19Br2ClN2O Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

SDS of cas: 54-17-1On October 15, 2020 ,《Microwave-assisted synthesis of nutgall tannic acid-based salecan polysaccharide hydrogel for tunable release of β-lactoglobulin》 was published in International Journal of Biological Macromolecules. The article was written by Hu, Xinyu; Yan, Linlin; Wang, Yongmei; Xu, Man. The article contains the following contents:

The low stability of β-lactoglobulin (βlg) under gastric conditions decreases the protein amount reaching the small intestine. Thus, it is crucial to develop a vehicle that can protect βlg from the stomach harsh acidity and enable its sustained and prolonged release in the small intestine. Herein, a fresh hydrogel composed of salecan-g-poly(N,N-dimethylaminoethyl acrylate) (PDMAEA) and nutgall tannic acid (TA) was fabricated by microwave-assisted polymerization The incorporation of salecan into hydrogels markedly affected the hydrogels thermal stability, microstructure, and mech. strength. Particularly, the multiple phenolic groups of TA can form complexes with βlg, and this enables the highly effective loading of proteins. As expected, βlg not only achieved effective entrapment into the hydrogels but also achieved a tunable and pH-controlled release. Such a release profile will enable βlg protection in the stomach and its targeted release in the small intestine. Increasing the salecan content dramatically enhanced the βlg release in simulated intestinal fluid (SIF). Furthermore, the βlg release was driven by Fickian diffusion in simulated gastric fluid (SGF), but the mechanism changed to non-Fickian diffusion in SIF. The release mechanism excellently matched Ritger-Peppas model. Overall, these results indicate that TA/salecan-g-PDMAEA hydrogels hold great potential for protein delivery in the gastrointestinal tract. The results came from multiple reactions, including the reaction of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1SDS of cas: 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.SDS of cas: 54-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Product Details of 54-17-1On March 31, 2019, Ashraf, Muhammad; Ahmad, Manzoor; Ahmad, Hanif; Ahmad, Shujaat published an article in Pakistan Journal of Pharmaceutical Sciences. The article was 《Phytochemical investigation of Hyoscyamus albus》. The article mentions the following:

The work presented in this paper illustrates the isolation and structure elucidation of secondary metabolites of Hyoscyamus albus. Two new natural source and three known compounds were isolated from the Hyoscyamus albus. Among the isolated compounds, grivilloside H (1) and betulaplatoside (2) were isolated for the first time while scopolamine (3), β-sitosterol (4) and stigmasterol (5) have been reported previously from the same plant. The structures of all the isolated compounds were established by using modern spectroscopic technique (UV, IR, NMR, and EI-MS) and by comparing with those available in literature. In the experiment, the researchers used many compounds, for example, rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Product Details of 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Product Details of 54-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2012,Angewandte Chemie, International Edition included an article by Brueck, Andreas; Gallego, Daniel; Wang, Wenyuan; Irran, Elisabeth; Driess, Matthias; Hartwig, John F.. Electric Literature of C14H21BO2. The article was titled 《Pushing the σ-donor strength in iridium pincer complexes: bis(silylene) and bis(germylene) ligands are stronger donors than bis(phosphorus(III)) ligands》. The information in the text is summarized as follows:

Iridium(III) and rhodium(III) E,C,E-pincer complexes (E = silylene, germylene) were prepared and compared with the corresponding P,C,P-pincer complexes (P = phosphinite, phosphorodiamidite) on their structural features and catalytic activity in direct borylation of aromatic hydrocarbons. Potentially tridentate benzamidinate-supported 1,3-[PhC(NtBu)2EO]2-4,6-tBu2C6H2 (HL1, HL2, E = Si, Ge) proligands were prepared by reaction of deprotonated 4,6-di-tert-butylresorcinol with chlorosilylene and chlorogermylene compounds ClE(tBuN)2CPh. The heavier bis-carbene analogs HL1, HL2 undergo metalation of the benzene ring 2-position with [IrCl(coe)2]2 yielding Ir(III) hydride complexes [(L1-Si,C,Si)IrHCl(coe)] and [(L2-Ge,C,Ge)IrHCl(coe)] (coe = cyclooctene). Metalation of Si,CH,Si-pincer proligand HL1 with [IrH(CO)(PPh3)3] and [RhCl(PPh3)2] gave trans,mer-[(L1-Si,C,Si)IrH2(CO)] and [(L1-Si,C,Si)RhHCl(PPh3)], resp. Iridium complexes were tested as catalysts for direct borylation of benzene and toluene with HBPin, catalyzed by [IrCl(coe)2]2/E,CH,E (1:2.1 mol ratio, 5 mol%), yielding arylboronates with 80% yields in the presence of free COE as a hydrogen acceptor. In comparison with the corresponding P,C,P-pincer ligands, the E,C,E-ligands provide more σ-donicity and ensure more stability for the six-coordinate M species, making the IrH2 dihydrides less prone to reductive elimination of dihydrogen in the course of direct borylation, which causes beneficial role of the sacrificial alkene as hydrogen acceptor.2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0Electric Literature of C14H21BO2) was used in this study.

2-(3,4-Dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 401797-00-0) belongs to hydroxy-containing compounds. Hydroxy-containing compounds engage in intermolecular hydrogen bonding increasing the electrostatic attraction between molecules and thus to higher boiling and melting points than found for compounds that lack this functional group. Organic compounds, which are often poorly soluble in water, become water-soluble when they contain two or more hydroxy groups, as illustrated by sugars and amino acid.Electric Literature of C14H21BO2

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Alcohol – Wikipedia,
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In 2021,International Journal of Electrochemical Science included an article by Li, Lina. Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride. The article was titled 《Electrochemical methods for quantitative estimation of ambroxol hydrochloride in drug for the treatment of asthmatic bronchitis》. The information in the text is summarized as follows:

This study presented the electrochem. quant. estimation of ambroxol hydrochloride (AHC) as drug safety for asthmatic bronchitis on ZnO nanoparticles electrodeposited on carboxylated CNTs modified glassy carbon electrode (ZnO NPs/c-CNTs/GCE). The electrodeposition technique was applied for the preparation of the ZnO NPs/c-CNTs/GCE. The structural and morphol. analyses using FESEM and XRD showed ZnO NPs in hexagonal wurtzite crystal structure electrodeposited on the twisted and wrapped tubular structure of c-CNTs. The electrochem. study using the CV technique showed that ZnO NPs/c-CNTs/GCE indicated lower peak potential, higher sensitivity and stability than c-CNTs/GCE and ZnO NPs/GCE due to the synergetic effect of ZnO NPs and c-CNTs. The studies of interference and concentration effects using DPV technique showed to the selective response of ZnO NPs/c-CNTs/GCE to the electrochem. determination of AHC, and the linear range, sensitivity and detection limit were obtained 1 to 120μM, 10.7393μA/μM and 0.02μM, resp. The practical ability of ZnO NPs/SWCNTs modified GCE was investigated for the determination of AHC content in ambroxol hydrochloride syrup as a real sample. The results evidenced to good precision and appropriate validity for practical analyses in pharmaceutical samples. In the experiment, the researchers used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts