Month: October 2022

Recommanded Product: 6381-59-5In 2017 ,《Theoretical and experimental features of nano-crystals Rochelle salt: piezoelectric resonance and phase transition》 was published in Journal of Nanoscience and Nanotechnology. The article was written by Pereira, D. P.; Del Nero, J.; Moreira, M. Dionizio; de Oliveira, P. C.; Alcantara, P.; Remedios, C. M. R.; Moreira, S. G. C.. The article contains the following contents:

A new methodol. based on Three-Electrode System (TES) technique was used to measure both, elastic (C44) and piezoelec. (d14) constants of Rochelle salt (RS) crystal. This technique was also used to observe the phase transitions at -18 °C and 24 °C, manifested as an increase of the output signal at these temperatures Mech. wave attenuation coefficient (α) into the crystal was found. Also, first principle methodol. in the framework of the d. functional theory was utilized to confirm the electronic structure of Rochelle Salt. The results present high accuracy theor./exptl. as well as a complete agreement with those known in the literature done by different methodologies. In the experiment, the researchers used many compounds, for example, Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5Recommanded Product: 6381-59-5)

Potassium sodium (2R,3R)-2,3-dihydroxysuccinate tetrahydrate(cas: 6381-59-5) is a ferroelectric crystal with a high piezoelectric effect and electromechanical coupling coefficient. Recommanded Product: 6381-59-5 Potassium sodium tartrate tetrahydrate has been used in the preparation of Lowry reagent for the determination of microsomal protein concentration in rat hepatic microsomes by Lowry method.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of C9H6O6In 2020 ,《Solid-Vapor Interface Engineered Covalent Organic Framework Membranes for Molecular Separation》 was published in Journal of the American Chemical Society. The article was written by Khan, Niaz Ali; Zhang, Runnan; Wu, Hong; Shen, Jianliang; Yuan, Jinqiu; Fan, Chunyang; Cao, Li; Olson, Mark A.; Jiang, Zhongyi. The article contains the following contents:

Covalent organic frameworks (COFs) with intrinsic, tunable, and uniform pores are potent building blocks for separation membranes, yet poor processing ability and long processing time remain grand challenges. Herein, we report an engineered solid-vapor interface to fabricate a highly crystalline two-dimensional COF membrane with a thickness of 120 nm in 9 h, which is 8 times faster than the reported literature. Due to the ultra-thin nature and ordered pores, the membrane exhibited an ultra-high permeance (water ∼ 411 L m-2 h-1 bar-1 and acetonitrile ∼ 583 L m-2 h-1 bar-1) and excellent rejection of dye mols. larger than 1.4 nm (> 98%). The membrane exhibited long-term operation which confirmed its outstanding stability. Our solid-vapor interfacial polymerization method may evolve into a generic platform to fabricate COFs and other organic frameworks membranes. The results came from multiple reactions, including the reaction of 2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4Synthetic Route of C9H6O6)

2,4,6-Trihydroxybenzene-1,3,5-tricarbaldehyde(cas: 34374-88-4) is a member of phloroglucinol derivatives. Phloroglucinol derivatives are a major class of secondary metabolites. Phloroglucinol compounds can be classified into monomeric, dimeric, trimeric and higher phloroglucinols, and phlorotannins.Synthetic Route of C9H6O6

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Alcohol – Wikipedia,
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HPLC of Formula: 156-87-6In 2022 ,《Structure-Activity Correlation Analyses of MEA + 3A1P/MAE Isomers with a Coordinative Effect Study》 was published in Industrial & Engineering Chemistry Research. The article was written by Shi, Huancong; Cheng, Xiaofang; Peng, Jiacheng; Feng, Hongliang; Yang, Xuan; Quan, Luoqiu; Jiang, Linhua; Tontiwachwuthikul, Paitoon. The article contains the following contents:

The “”coordinative effect””, which enhances absorption and desorption performance of single RR’NH at once, was verified repeatedly within MEA + BEA, MEA + DEA, and MEA + BEA + AMP. This work studied the “”coordinative effect”” within specific MEA + 3-amino-1-propanol 3A1P(RNH2) and MEA + 2-(methylamine)ethanol MAE(RR’NH). The amine 3A1P and MAE were isomers with the same formula but different mol. structures. Both CO2 absorption and desorption tests were conducted in bi-solvents MEA + 3A1P and MEA + MAE sep., with the help of CO2 absorption-desorption parameters. Exptl. results demonstrated that the “”coordinative effect”” existed within MEA + 3A1P and MEA + MAE. Both CO2 absorption/desorption performances of MEA + 3A1P/MAE were superior to those of 3A1P/MAE single amine simultaneously. The coordinative effect reached an optimum ratio for amine blends at 0.2-0.3 + 2 mol/L of MEA + 3A1P and 0.3 + 2 mol/L of MEA + MAE. Based on scientific anal., carbamate stability is the dominant factor contributing to strong or negligible coordinative effects of MEA + AMP and 3A1P. The synthesized MEA + RR’NH will be blended with other R3N/AMP to generate tri-solvents with a large concentration and cyclic capacities for industrial applications. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6HPLC of Formula: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.HPLC of Formula: 156-87-6

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Alcohol – Wikipedia,
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Product Details of 89466-08-0In 2021 ,《Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogs as new KRASG12C inhibitors》 was published in European Journal of Medicinal Chemistry. The article was written by Xiao, Xuanzheng; Lai, Mengzhen; Song, Zilan; Geng, Meiyu; Ding, Jian; Xie, Hua; Zhang, Ao. The article contains the following contents:

KRAS is the most commonly altered oncogene of the RAS family, especially the G12C mutant (KRASG12C), which has been a promising drug target for many cancers. On the basis of the bicyclic pyridopyrimidinone framework of the first-in-class clin. KRASG12C inhibitor AMG510, a scaffold hopping strategy was conducted including a F-OH cyclization approach and a pyridinyl N-atom working approach leading to new tetracyclic and bicyclic analogs. Compound (I) was identified possessing binding potency of 1.87μM against KRASG12C and cell growth inhibition of 0.79μM in MIA PaCa-2 pancreatic cancer cells. Treatment of I with NCI-H358 cells resulted in down-regulation of KRAS-GTP levels and reduction of phosphorylation of downstream ERK and AKT dose-dependently. Mol. docking suggested that the fluorophenol moiety of I occupies a hydrophobic pocket region thus forming hydrogen bonding to Arg68. These results will be useful to guide further structural modification.2-Hydroxyphenylboronic acid(cas: 89466-08-0Product Details of 89466-08-0) was used in this study.

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA), a synthetic molecule applied in RNA affinity chromatography, is able to form reversible covalent ester bonds with 1,2- or 1,3-cis-doils on the ribose ringProduct Details of 89466-08-0

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Alcohol – Wikipedia,
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SDS of cas: 156-87-6In 2020 ,《Experimental Study of Some Thermodynamic Properties of Binary Mixtures Containing 3-Amino-1-propanol, 2-Aminoethanol, and 1-Butanol at Temperatures of 293.15-333.15 K to Model the Excess Molar Volumes Using the PFP Theory》 was published in Journal of Chemical & Engineering Data. The article was written by Kermanpour, Fakhri; Kheyrabadi, Zahra Gharagozlo. The article contains the following contents:

D., ρ, and viscosity, η, of pure components of 2-aminoethanol, 1-butanol, and 3-amino-1-propanol, along with the binary mixtures of {x12-aminoethanol + x21-butanol}, {x13-amino-1-propanol + x21-butanol}, and {x13-amino-1-propanol + x22-aminoethanol}, were determined over the whole composition range and in the temperatures of 293.15-333.15 at ambient pressure p = 86 kPa. The exptl. values of d. and viscosity have been used to calculate the excess molar volume, VmE, partial molar volumes, V̅1 and V̅2, excess partial molar volumes, V̅1E and V̅2E, thermal expansion coefficient, α, excess thermal expansion coefficient, αE, and viscosity deviation, Δη, of binary mixtures The results show that excess molar volumes of the mixtures are neg. in the whole composition range and increase with increasing temperature Viscosity deviations, Δη, of two former mixtures are neg. over the entire composition range and decrease with increasing temperature, while the Δη values of the later mixture are pos. over the entire composition range and decrease with the increasing temperature The excess properties were correlated by the Redlich-Kister equation, and their fitting parameters and standard deviations were determined The excess molar volumes were also correlated by applying the Prigogine-Flory-Patterson (PFP) model, and their interaction parameters, χ12, were obtained. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6SDS of cas: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.SDS of cas: 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《A novel approach to nonsurgical sterilization; application of menadione-modified gonocyte-targeting M13 bacteriophage for germ cell ablation in utero》 was published in Pharmacology Research & Perspectives in 2020. These research results belong to Fraser, Barbara A.; Miller, Kasey; Trigg, Natalie A.; Smith, Nathan D.; Western, Patrick S.; Nixon, Brett; Aitken, Robert J.. Safety of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate The article mentions the following:

There remains a compelling need for the development of nonsurgical sterilizing agents to expand the fertility management options for both domestic and feral animal species. We hypothesize that an efficacious sterilization approach would be to selectively ablate nonrenewable cell types that are essential for reproduction, such as the undifferentiated gonocytes within the embryonic gonad. Here, we report a novel strategy to achieve this goal centered on the use of a chem. modified M13 bacteriophage to effect the targeted delivery of menadione, a redox-cycling naphthoquinone, to mouse gonocytes. Panning of the M13 random peptide phage display library proved effective in the isolation of gonocyte-specific targeting clones. One such clone was modified via N-succinimidyl-S-acetylthioacetate (SATA) linkage to the N-terminus of the major PVIII capsid protein. Subsequent deacetylation of the SATA was undertaken to expose a thiol group capable of reacting with menadione through Michael addition This chem. modification was confirmed using UV spectrophotometry. In proof-of-concept experiments we applied the modified phage to primary cultures of fetal germ cells and induced, an approx., 60% reduction in the viability of the target cell population. These studies pave the way for in vivo application of chem. modified M13 bacteriophage in order to achieve the selective ablation of nonrenewable cell types in the reproductive system, thereby providing a novel nonsurgical approach the regulation of fertility in target species. In addition to this study using 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate, there are many other studies that have used 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6Safety of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate) was used in this study.

2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate(cas: 76931-93-6) belongs to pyrrolidine. Pyrrolidine on reaction with ketenedithioacetals gave mono- and dipyrrolidino derivatives. Reaction of parent pyrrolidine with alkyl/aryl isocyanates or isothiocyanates provided 1,3-disubstituted ureas/thioureas.Safety of 2,5-Dioxopyrrolidin-1-yl 2-(acetylthio)acetate

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《Dienamine-Induced Divinylcyclopropane-Cycloheptadiene Rearrangements》 was written by Apel, Caroline; Hartmann, Sven Soeren; Lentz, Dieter; Christmann, Mathias. Related Products of 78782-17-9This research focused onvinylcyclopropyl butenal preparation pyrrolidinyl methoxysilane catalyst Cope rearrangement condensation; cycloheptadienyl acetaldehyde diastereoselective preparation; Cope rearrangement; cycloheptadienes; cyclopropanes; organocatalysis; pericyclic reactions. The article conveys some information:

The first organocatalytic Cope rearrangement of in-situ generated divinylcyclopropanes. The reactive motif was generated by condensation of 4-(2-vinylcyclopropyl)but-2-enal derivatives with a secondary amine catalyst to form a transient dienamine. The cycloheptadiene products was obtained in high yield and excellent diastereoselectivity. Importantly, the reaction was demonstrated to be stereospecific, proceeding under mild conditions, while exhibiting broad functional group tolerance. The experimental process involved the reaction of Bis[(pinacolato)boryl]methane(cas: 78782-17-9Related Products of 78782-17-9)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Related Products of 78782-17-9 Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Titanium Salen Complexes with Appended Silver NHC Groups as Nucleophilic Carbene Reservoir for Cooperative Asymmetric Lewis Acid/NHC Catalysis》 was written by Latendorf, Katja; Mechler, Melanie; Schamne, Irina; Mack, Daniel; Frey, Wolfgang; Peters, Rene. COA of Formula: C9H11NOThis research focused ontitanium salen complex silver NHC preparation asym dimerization catalyst. The article conveys some information:

Lewis acid catalysis and nucleophilic carbene catalysis are complementary fundamental concepts to accelerate and control chem. reactions of aldehyde substrates. Their efficient merger has recently been achieved using two sep. catalyst species. The present report describes our efforts to develop a cooperative catalyst system which incorporates both features – Lewis acid and nucleophilic NHC – within the same catalyst entity. To generate free carbene moieties under very mild conditions, Ag-NHC complexes were formed releasing the nucleophilic carbene upon treatment with PPh3. The result is the formation of an enol-δ-lactone as new enal dimerization product. Silver is essential for the reactivity mode thus suggesting that it plays a double role in the catalytic event. In addition to this study using (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol, there are many other studies that have used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7COA of Formula: C9H11NO) was used in this study.

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.COA of Formula: C9H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanolOn September 13, 2021 ,《Chemoselective, Scalable Nickel-Electrocatalytic O-Arylation of Alcohols》 was published in Angewandte Chemie, International Edition. The article was written by Zhang, Hai-Jun; Chen, Longrui; Oderinde, Martins S.; Edwards, Jacob T.; Kawamata, Yu; Baran, Phil S.. The article contains the following contents:

Herein a Ni-catalyzed electrochem. driven protocol to afford aryl-alkyl ether bonds through O-arylation of alcs. was depicted. This electrochem. method did not require strong base, exogenous expensive transition metal catalysts (e.g., Ir, Ru), and could easily be scaled up in either a batch or flow setting. Interestingly, e-etherification exhibited an enhanced substrate scope over the mechanistically related photochem. variant as it tolerated tertiary amine functional groups in the alc. nucleophile. with a broad substrate scope in an operationally simple way. After reading the article, we found that the author used ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Reference of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​. And it is used as chiral auxiliaries in Michael and Aldol addition reactions.Reference of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocksOn November 2, 2020 ,《Alkylation-Terminated Catellani Reactions Using Alkyl Carbagermatranes》 appeared in Angewandte Chemie, International Edition. The author of the article were Jiang, Wei-Tao; Xu, Meng-Yu; Yang, Shuo; Xie, Xiu-Ying; Xiao, Bin. The article conveys some information:

The Catellani reaction has received substantial attention because it enables rapid multiple derivatization on aromatics While using alkyl electrophiles to achieve ortho-alkylation was one of the earliest applications of the Catellani reaction, ipso-alkylation-terminated reactions with β-H-containing reactants has not been realized to date. Herein, we report alkylation-terminated Catellani reaction using alkyl carbagermatranes (abbreviated as alkyl-Ge) as nucleophiles. The reactivity of alkyl-Ge and alkyl-B(OH)2 in this reaction is discussed. This approach enables efficient dialkylation with β-H-containing reactants, which was previously inaccessible by Catellani reactions. The results came from multiple reactions, including the reaction of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6Category: alcohols-buliding-blocks)

((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol(cas: 20880-92-6) is a useful reactant for examining the effectiveness of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-​II (CA-​II)​.Category: alcohols-buliding-blocks And it is used as chiral auxiliaries in Michael and Aldol addition reactions.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts