Month: October 2022

Castro, David J.; Gomez-Altuve, Andreina; Reina, Jose Carlos; Rodriguez, Miguel; Sampedro, Inmaculada; Llamas, Inmaculada; Martinez-Checa, Fernando published the artcile< Roseovarius bejariae sp. nov., a moderately halophilic bacterium isolated from a hypersaline steep-sided river bed>, Related Products of 87-73-0, the main research area is hypersaline steep sided river bed halophilic bacterium Roseovarius bejariae; Roseovarius bejariae sp. nov.; halophilic bacteria; polyphasic taxonomy; saline soil.

An aerobic, Gram-stain-neg. ovoid, designated as strain A21T, was isolated using the dilution-to-extinction method from a soil sample taken from Rambla Salada, an athalassohaline habitat located in Murcia (south-eastern Spain). Strain A21T is nonmotile, has a respiratory metabolism and grows at NaCl concentrations within the range 0.5-15% (w/v) [optimum, 5% (w/v)], at 5-35°C (optimum, 28°C) and at pH 6-8 (optimum, pH 7.0). This strain is pos. for catalase activity, oxidase activity and nitrate reduction The 16S rRNA gene sequence indicates that it belongs to the genus Roseovarius in the class Alphaproteobacteria. The most closely related species are Roseovarius pacificus and Roseovarius halotolerans to which the strain A21T shows 16S rRNA gene sequence similarity values of 98.06 and 97.7%, resp. The average nucleotide identity in blast and digital DNA-DNA hybridization values between strain A21T and R. pacificus LMG 24575T are 76.8 and 21%, resp. The DNA G+C content based on the genome is 61.28mol%. The major fatty acids (>5% of the total fatty acids) of strain A21T are C18:1ω7c/C18:1ω and C18:1. The only detected isoprenoid quinone in strain A21T is ubiquinone 10 (Q-10). The polar lipid profile contains phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol and three unidentified polar lipids. Based on the phylogenetic, genotypic, phenotypic and chemotaxonomic data, the strain represents a novel species of the genus Roseovarius, for which the name Roseovarius bejariae sp. nov. is proposed. Strain A21T (=CECT 9817T =LMG 31311T) is the type strain.

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Related Products of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carlberg, Carsten; Velleuer, Eunike published the artcile< Vitamin D and the risk for cancer: A molecular analysis>, Category: alcohols-buliding-blocks, the main research area is review colon prostate breast cancer vitamin D receptor transcriptomics; Cancer prevention; Colon cancer; Epigenome; Evolution; Immune system; Transcriptome; VDR; Vitamin D; Vitamin D response index; Vitamin D status; Vitamin D target genes.

A review. Uncontrolled overgrowth of cells, such as in cancer, is an unavoidable risk in life that affects nearly every second individual in industrialized countries. However, in part this risk can be controlled through lifestyle adjustments, such as the avoidance of smoking, unhealthy diet, obesity, phys. inactivity and other cancer risk factors. A low vitamin D status is a risk in particular for cancers of colon, prostate, breast and leukocytes. Vitamin D3 is produced non-enzymically, when the cholesterol precursor 7-dehydrocholesterol is exposed to UV-B from sunlight, i.e., all cholesterol synthesizing species, including humans, can make vitamin D3. Vitamin D endocrinol. started some 550 million years ago, when the metabolite 1α,25-dihydroxyvitamin D3 and the transcription factor vitamin D receptor teamed up for regulating the expression of hundreds of target genes in a multitude of different tissues and cell types. Initially, these genes were focused on the control of energy homeostasis, which later also involved energy-demanding innate and adaptive immunity. Rapidly growing cells of the immune system as well as those of malignant tumors rely on comparable genes and pathways, some of which are modulated by vitamin D. Accordingly, vitamin D has anti-cancer effects both directly via controlling the differentiation, proliferation and apoptosis of neoplastic cells as well as indirectly through regulating immune cells that belong to the microenvironment of malignant tumors. This review discusses effects of vitamin D on the epigenome and transcriptome of stromal and tumor cells, inter-individual variations in vitamin D responsiveness and their relation to the prevention and possible therapy of cancer.

Biochemical Pharmacology (Amsterdam, Netherlands) published new progress about Adaptive immunity. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Shuai; Xu, Chang-Yuan; Xia, Jie; Feng, Yan-Ni; Zhang, Xi-Feng; Yan, You-Yu published the artcile< Extraction of polysaccharides from Codonopsis pilosula by fermentation with response surface methodology>, Electric Literature of 3458-28-4, the main research area is Codonopsis polysaccharide antioxidant response surface methodol; antioxidation; codonopsis; polysaccharide; response surface method.

Codonopsis pilosula is a kind of traditional Chinese medicine used to treat weak spleens, stomach problems, anemia, and fatigue. Polysaccharide is one of main components of Codonopsis pilosula. In this study, response surface methodol. (RSM) was used to optimize the extraction parameters of Codonopsis pilosula polysaccharides (CPP) by fermentation The exaction temperature (°C), yeast liquid volume (2 mg/mL, ml), and time (h) were employed effects. Results indicated that the best extraction conditions were the following: extraction temperature 24.75°C, yeast liquid volume 2.96 mL (5.92 mg), and a fermentation time of 21.03 h. After purification with DE52 and Sephadex G-100, the mol. structure was determined by UV-visible (UV) spectroscopy, Fourier transform IR (FTIR) spectroscopy, and NMR (NMR) (1H and 13C). The monosaccharide composition of CPP1 was determined to be mannose (1.76%), glucose (97.38%), and arabinose (0.76%). CPP1 exhibited high antioxidant activities in scavenging ABTS radicals, ferreous ions, and superoxide ion radicals. Thus, CPP1 could be used as an antioxidant or functional food.

Food Science & Nutrition (Hoboken, NJ, United States) published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Electric Literature of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Chen; Hong, Gang; Nahide, Pradip D.; He, Yuchen; Zhou, Chen; Kozlowski, Marisa C.; Wang, Limin published the artcile< C(sp3)-H Hydroxylation of fluorenes, oxindoles and benzofuranones with a Mg(NO3)2-HP(O)Ph2 oxidation system>, Safety of Triphenylmethanol, the main research area is hydroxyfluorene preparation; fluorene hydroxylation; hydroxyoxindole preparation; oxindole hydroxylation; hydroxybenzofuranone preparation; benzofuranone hydroxylation.

A novel oxidation system consisting of magnesium nitrate [Mg(NO3)2] as an oxidant in the presence of diphenylphosphine oxide [HP(O)Ph2] was developed for the synthesis of hydroxyfluorenes I [R = n-Pr, Ph, 1-naphthyl, etc.; R1 = H, 2-NO2], hydroxyoxindoles II [R2 = Me, Ph, Bn, etc.; R3 = H, 5-Me, 5-t-Bu, etc.; X = NMe, NBn] and hydroxybenzofuranones II [X = O] via C(sp3)-H hydroxylation of fluorenes, oxindoles and benzofuranones. This method featured high efficiency, good functional group tolerance and operational simplicity.

Organic Chemistry Frontiers published new progress about Benzofurans Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hata, Taishi; Hagihara, Kiyotaka; Tsutsui, Anna; Akamatsu, Hiroki; Ohue, Masayuki; Shingai, Tatsushi; Tei, Mitsuyoshi; Ikenaga, Masakazu; Kim, Ho Min; Osawa, Hideki; Takemoto, Hiroyoshi; Konishi, Ken; Uemura, Mamoru; Matsuda, Chu; Mizushima, Tsunekazu; Murata, Kohei; Ohno, Yuko; Doki, Yuichiro; Eguchi, Hidetoshi published the artcile< Administration Method of Adjuvant Tegafur-Uracil and Leucovorin Calcium in Patients with Resected Colorectal Cancer: A Phase III Study>, Product Details of C20H21CaN7O7, the main research area is tegafur uracil leucovorin calcium adjuvant administration human colorectal cancer; Colorectal cancer; Leucovorin calcium; Phase III; Tegafur-uracil.

The 3-yr disease-free survival rate of the twice-daily regimen was not inferior to that of the conventional three-times-daily regimen, and the twice-daily regimen did not lead to an increase in adverse events. The effectiveness of the twice-daily regimen highlights an increased number of treatment options for patients. This will facilitate personalized medicine, particularly for elderly or frail patients who may experience more severe side effects from the combination therapy. Tegafur-uracil (UFT)/leucovorin calcium (LV) is an adjuvant chemotherapy treatment for colorectal cancer. We conducted a multicenter randomized trial to assess the noninferiority of a twice-daily compared with a three-times-daily UFT/LV regimen for stage II/III colorectal cancer in an adjuvant setting. Patients were randomly assigned to group A (three doses of UFT [300 mg/m2 per day]/LV [75 mg per day]) or B (two doses of UFT [300 mg/m2 per day]/LV [50 mg per day]). The primary endpoint was 3-yr disease-free survival. In total, 386 patients were enrolled between July 28, 2011, and Sept. 27, 2013. The 3-yr disease-free survival rates of group A (n = 194) and B (n = 192) were 79.4% and 81.4% (95% confidence interval, 72.6-84.4-74.5-85.9), resp. The most common grade 3/4 adverse events in group A and B were diarrhea (3.9% vs. 7.3%), neutropenia (2.9% vs. 1.6%), increase in aspartate aminotransferase (4.0% vs. 3.9%), increase in alanine aminotransferase (6.2% vs. 6.8%), nausea (1.7% vs. 3.4%), and fatigue (1.1% vs. 2.3%). Group B outcomes were not inferior to group A outcomes, and adverse events did not increase.

Oncologist published new progress about Anorexia. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Product Details of C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jeyaraman, Maya M; Al-Yousif, Nameer S H; Singh Mann, Amrinder; Dolinsky, Vernon W; Rabbani, Rasheda; Zarychanski, Ryan; Abou-Setta, Ahmed M published the artcile< Resveratrol for adults with type 2 diabetes mellitus.>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is .

BACKGROUND: Type 2 diabetes mellitus (T2DM) is a chronic disorder that is characterised by insulin resistance and hyperglycaemia, which over time may give rise to vascular complications. Resveratrol is a plant-derived nutritional supplement shown to have anti-diabetic properties in many animal models. Less evidence is available on its safety and efficacy in the management of T2DM in humans. OBJECTIVES: To assess the efficacy and safety of resveratrol formulations for adults with type 2 diabetes mellitus. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, PubMed, Embase, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), and International Pharmaceutical Abstracts, as well as the International Clinical Trials Registry Platform (ICTRP) Search Portal and ClinicalTrials.gov. The date of the last search was December 2018 for all databases. No language restrictions were applied. SELECTION CRITERIA: All randomised controlled trials (RCTs) comparing effects of oral resveratrol (any dose or formulation, duration, or frequency of administration) with placebo, no treatment, other anti-diabetic medications, or diet or exercise, in adults with a diagnosis of T2DM. DATA COLLECTION AND ANALYSIS: Two review authors independently identified and included RCTs, assessed risk of bias, and extracted study-level data. Study authors were contacted for any missing information or for clarification of reported data. We assessed studies for certainty of the evidence using the GRADE instrument. MAIN RESULTS: We identified three RCTs with a total of 50 participants. Oral resveratrol not combined with other plant polyphenols was administered at 10 mg, 150 mg, or 1000 mg daily for a period ranging from four weeks to five weeks. The comparator intervention was placebo. Overall, all three included studies had low risk of bias. None of the three included studies reported long-term, patient-relevant outcomes such as all-cause mortality, diabetes-related complications, diabetes-related mortality, health-related quality of life, or socioeconomic effects. All three included studies reported that no adverse events were observed, indicating that no deaths occurred (very low-quality evidence for adverse events, all-cause mortality, and diabetes-related mortality). Resveratrol versus placebo showed neutral effects for glycosylated haemoglobin A1c (HbA1c) levels (mean difference (MD) 0.1%, 95% confidence interval (CI) -0.02 to 0.2; P = 0.09; 2 studies; 31 participants; very low-certainty evidence). Due to the short follow-up period, HbA1c results have to be interpreted cautiously. Similarly, resveratrol versus placebo showed neutral effects for fasting blood glucose levels (MD 2 mg/dL, 95% CI -2 to 7; P = 0.29; 2 studies; 31 participants), and resveratrol versus placebo showed neutral effects for insulin resistance (MD -0.35, 95% CI -0.99 to 0.28; P = 0.27; 2 studies; 36 participants). We found eight ongoing RCTs with approximately 800 participants and two studies awaiting assessment, which, when published, could contribute to the findings of this review. AUTHORS’ CONCLUSIONS: Currently, research is insufficient for review authors to evaluate the safety and efficacy of resveratrol supplementation for treatment of adults with T2DM. The limited available research does not provide sufficient evidence to support any effect, beneficial or adverse, of four to five weeks of 10 mg to 1000 mg of resveratrol in adults with T2DM. Adequately powered RCTs reporting patient-relevant outcomes with long-term follow-up periods are needed to further evaluate the efficacy and safety of resveratrol supplementation in the treatment of T2DM.

The Cochrane database of systematic reviews published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mahdian, Abolfazl; Ardakani, Mehdi Hatefi; Heydari-Bafrooei, Esmaeil; Saeednia, Samira published the artcile< Oxo-vanadium(IV) unsymmetrical Schiff base complex immobilized on γ-Fe2O3 nanoparticles: A novel and magnetically recoverable nanocatalyst for selective oxidation of sulfides and oxidative coupling of thiols>, Application In Synthesis of 699-12-7, the main research area is thioether Schiff base complex catalyst selective oxidation green chem; thiol supported oxovanadium Schiff base complex catalyst oxidative coupling; iron oxide support oxovanadium Schiff base complex preparation crystallinity.

An unsym. salen-type oxo-vanadium(IV) complex, [VO(salenac-OH)] (salenac-OH = [9-(2′,4′-dihydroxyphenyl)-5,8-diaza-4-methylnona-2,4,8-trienato](-2)), was synthesized and covalently immobilized on the surface of magnetic γ-Fe2O3 nanoparticles. The resulting γ-Fe2O3@[VO(salenac-OH)] nanoparticles were characterized by several techniques including Fourier transform IR (FT-IR) spectroscopy, X-ray diffraction (XRD), scanning and transmission electron microscopies (SEM and TEM), energy-dispersive X-ray (EDX) spectroscopy, vibrating sample magnetometry (VSM), thermal gravimetric anal. (TGA), inductively coupled plasma (ICP), and elemental anal. The prepared γ-Fe2O3@[VO(salenac-OH)] nanoparticle was utilized as an efficient catalyst for selective oxidation of sulfides to sulfoxides using 30% H2O2 as oxidant and oxidative coupling of thiols into disulfides with urea/H2O2 (UHP) as an oxidizing reagent. The products were achieved with good to excellent yields at room temperature with no over-oxidation of sulfoxides and disulfides to unexpected byproducts. This catalyst were magnetically recovered by applying an external magnet and reused for five continuous cycles in both oxidation reactions without a significant loss in its catalytic activity. Furthermore, the FT-IR spectrum and XRD pattern of the recovered catalyst showed no critical change to those of the fresh one.

Applied Organometallic Chemistry published new progress about Crystallinity. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Application In Synthesis of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jiang, Yuan-yuan; Yu, Jun; Li, Ya-bo; Wang, Long; Hu, Liang; Zhang, Li; Zhou, Yong-hong published the artcile< Extraction and antioxidant activities of polysaccharides from roots of Arctium lappa L.>, COA of Formula: C6H12O6, the main research area is Arctium root polysaccharide ultrasonic assisted extraction antioxidant; Antioxidant activities; Arctium lappa L.; Polysaccharides; Ultrasonic-assisted extraction.

Polysaccharides were extracted from the roots of Arctium lappa L. (ALPs) using response surface methodol. with ultrasonication. A central composition design was used to optimize extraction parameters by maximizing the polysaccharide extraction yield. The modified optimal conditions were as follows: water to raw material ratio of 31 mL/g, ultrasonic power of 158 W, extraction time of 83 min, and extraction temperature of 50°C. Furthermore, fractions of ALP40-1, ALP60-1, and ALP80-1 were obtained for chem. and antioxidant activity analyses after purification Results indicated that the three fractions had a mol. weight of 218, 178, and 60 kDa, resp., and were composed of mannose, glucose, fructose, and galactose. ALP60-1 exhibited strong scavenging activities on 1,1-diphenyl-2-picryhydrazyl, hydroxyl, and superoxide radicals. These results demonstrate that ultrasonic-assisted extraction is a very effective method for extracting ALPs, and ALP60-1 is a potential novel natural antioxidant. However, further structure elucidation and in vivo experiments are required.

International Journal of Biological Macromolecules published new progress about Arctium lappa. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lubov, Dmitry P.; Bryliakova, Anna A.; Samsonenko, Denis G.; Sheven, Dmitriy G.; Talsi, Evgenii P.; Bryliakov, Konstantin P. published the artcile< Palladium-Aminopyridine Catalyzed C-H Oxygenation: Probing the Nature of Metal Based Oxidant>, Product Details of C19H16O, the main research area is palladium aminopyridine catalyzed carbon hydrogen bond oxygenation mechanism.

A mechanistic study of direct selective oxidation of benzylic C(sp3)-H groups with peracetic acid, catalyzed by palladium complexes with tripodal amino-tris(pyriylmethyl) ligands, is presented. The oxidation of arylalkanes having secondary and tertiary benzylic C-H groups, predominantly yields, depending on the substrate and conditions, either the corresponding ketones or alcs. One of the three 2-pyridylmethyl moieties, which is pending in the starting catalyst, apparently, facilitates the active species formation and takes part in stabilization of the high-valent Pd center in the active species, occupying the axial coordination site of palladium. The catalytic, as well as isotopic labeling experiments, in combination with ESI-MS data and DFT calculations, point out palladium oxyl species as possible catalytically active sites, operating essentially via C-H abstraction/oxygen rebound pathway. For the ketones formation, O-H abstraction/β-scission mechanism has been proposed.

ChemCatChem published new progress about Alkylarenes Role: PEP (Physical, Engineering or Chemical Process), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Liang; Castan, Andreas; Stevenson, Joanne; Chatzissavidou, Nathalie; Vilaplana, Francisco; Chotteau, Veronique published the artcile< Combined effects of glycosylation precursors and lactate on the glycoprofile of IgG produced by CHO cells>, Computed Properties of 3458-28-4, the main research area is CHO cell monoclonal antibodies IgG; Chinese hamster ovary cells (CHO cells); Glycosylation; IgG; Monoclonal antibody; Sugars; mAbs.

The glycosylation profile of therapeutic monoclonal antibodies (mAbs) is a crucial quality parameter for industrial IgG (IgG) production Several alternative carbon sources, which function as glycosylation precursors, have been reported to impact the glycosylation pattern. Since the cells give priority to glucose uptake, the presence of this substrate can lower the effects of alternative sugars on the glycosylation. In order to get a better understanding of the influence of alternative sugars on the glycosylation and to investigate how they impact each other, combinations of mannose, fructose, galactose and fucose were fed to Chinese hamster ovary (CHO) cells in batch culture when the glucose became depleted and the lactate, accumulated in the culture, was used as carbon source. Feeding with a feed containing mannose or glucose decreased by 3-7% the percentage of high mannose glycans compared to a feed without mannose or glucose. Feeding with a feed containing galactose led to 8-20% increase of monogalactoglycans (G1) glycans and 2-6% rise of digalactoglycans (G2) glycans compared to feeding without galactose or glucose. The cells fed with fucose exhibited a significantly higher concentration of intracellular GDP-Fucose. This work indicates that a feeding strategy based on non-glucose sugars and potentially lactate, could be adopted to obtain a targeted glycosylation profile.

Journal of Biotechnology published new progress about Antibodies and Immunoglobulins Role: BMF (Bioindustrial Manufacture), BIOL (Biological Study), PREP (Preparation). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Computed Properties of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts