Month: October 2022

《Elucidating the promotional effect of a covalent triazine framework in aerobic oxidation》 was published in Applied Catalysis, B: Environmental in 2020. These research results belong to Abednatanzi, Sara; Gohari Derakhshandeh, Parviz; Tack, Pieter; Muniz-Miranda, Francesco; Liu, Ying-Ya; Everaert, Jonas; Meledina, Maria; Vanden Bussche, Flore; Vincze, Laszlo; Stevens, Christian V.; Van Speybroeck, Veronique; Vrielinck, Henk; Callens, Freddy; Leus, Karen; Van Der Voort, Pascal. Application In Synthesis of 3-Pyridinemethanol The article mentions the following:

Synergistic catalysis holds great promise to enhance the catalytic performance of heterogeneous catalysts suffering from sluggish reaction kinetics. Much effort has been dedicated to the development of bimetallic systems in which the two promoter elements display synergistic benefits compared to monometallic counterparts. However, the use of bimetallic catalysts inescapably raises the cost of preparation and environmental issues. This study discovers a synergistic effect when using a bipyridine covalent triazine framework (bipy-CTF) as support for an IrIII complex in the aerobic oxidation reaction. The detailed mechanistic study provides insights into the function of the bipy-CTF in this synergistic catalysis. The EPR and in-situ XANES analyses confirm the applicability of bipy-CTF to activate oxygen and alc., resulting in an enhancement of the performance of the IrIII complex to exceed the activity of the homogeneous counterpart. This is an unprecedented report on promoting the activity of a heterogeneous catalyst through its solid support. The experimental part of the paper was very detailed, including the reaction process of 3-Pyridinemethanol(cas: 100-55-0Application In Synthesis of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application In Synthesis of 3-Pyridinemethanol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Poly(ethylene glycol)-Poly(beta-amino ester)-Based Nanoparticles for Suicide Gene Therapy Enhance Brain Penetration and Extend Survival in a Preclinical Human Glioblastoma Orthotopic Xenograft Model》 was written by Kim, Jayoung; Mondal, Sujan K.; Tzeng, Stephany Y.; Rui, Yuan; Al-kharboosh, Rawan; Kozielski, Kristen K.; Bhargav, Adip G.; Garcia, Cesar A.; Quinones-Hinojosa, Alfredo; Green, Jordan J.. Related Products of 13325-10-5 And the article was included in ACS Biomaterials Science & Engineering in 2020. The article conveys some information:

Glioblastoma (GBM) is the most devastating brain cancer, and cures remain elusive with currently available neurosurgical, pharmacol., and radiation approaches. While retrovirus- and adenovirus-mediated suicide gene therapy using DNA encoding herpes simplex virus-thymidine kinase (HSV-tk) and prodrug ganciclovir has been suggested as a promising strategy, a nonviral approach for treatment in an orthotopic human primary brain tumor model has not previously been demonstrated. Delivery challenges include nanoparticle penetration through brain tumors, efficient cancer cell uptake, endosomal escape to the cytosol, and biodegradability. To meet these challenges, we synthesized poly(ethylene glycol)-modified poly(beta-amino ester) (PEG-PBAE) polymers to improve extracellular delivery and coencapsulated plasmid DNA with end-modified poly(beta-amino ester) (ePBAE) polymers to improve intracellular delivery as well. We created and evaluated a library of PEG-PBAE/ePBAE nanoparticles (NPs) for effective gene therapy against two independent primary human stem-like brain tumor initiating cells, a putative target to prevent GBM recurrence. The optimally engineered PEG-PBAE/ePBAE NP formulation demonstrated 54 and 82% transfection efficacies in GBM1A and BTIC375 cells resp., in comparison to 37 and 66% for optimized PBAE NPs without PEG. The leading PEG-PBAE NP formulation also maintained sub-250 nm particle size up to 5 h, while PBAE NPs without PEG showed aggregation over time to micrometer-sized complexes. The comparative advantage demonstrated in vitro successfully translated into improved in vivo diffusion, with a higher amount of PEG-PBAE NPs penetrating to a distance of 2 mm from the injection site. A significant increase in median survival from 53.5 to 67 days by PEG-PBAE/pHSV-tk NP and systemic ganciclovir treatment compared to a control group in orthotopic murine model of human glioblastoma demonstrates the potential of PEG-PBAE-based NPs as an effective gene therapy platform for the treatment of human brain tumors. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Related Products of 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Structural reorganization and crack-healing properties of hydrogels based on dynamic diselenide linkages》 was written by Xu, Hao; Suzuki, Nao; Takahashi, Akira; Ohishi, Tomoyuki; Goseki, Raita; Xie, Xu-Ming; Otsuka, Hideyuki. Recommanded Product: 1195-59-1 And the article was included in Science and Technology of Advanced Materials in 2020. The article conveys some information:

We report the dynamic behavior of diselenide-containing hydrophilic polyurethanes and hydrogels based on diselenide exchange reactions in an aqueous media. Diselenide-containing linear and crosslinked polyurethanes were synthesized via polyaddition reactions using diselenide-containing diol in combination with pyridinium diol that enhances the hydrophilicity of the polymer chains. The obtained linear polyurethanes underwent photo-induced diselenide exchange reactions with small diselenide compounds and degraded to smaller fragments, confirming the dynamicity of the obtained hydrophilic polyurethanes. The prepared hydrogels displayed characteristic large swelling behavior based on the structural reorganization through diselenide exchange either under photo-irradiation at 365 nm or even in the dark at room temperature The diselenide-containing hydrogels also showed crack-healing behavior under the same exchanging conditions, presenting the utility of diselenide linkages as simple and useful units to offer high dynamicity to hydrogels. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 1195-59-1) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Recommanded Product: 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Synthesis and structure-activity relationship studies of LLY-507 analogues as SMYD2 inhibitors》 was written by Zhang, Bin; Liao, Liping; Wu, Fan; Zhang, Fengcai; Sun, Zhongya; Chen, Haijun; Luo, Cheng. Recommanded Product: 2-Hydroxyphenylboronic acid And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:

SET and MYND domain-containing protein 2 (SMYD2), a lysine methyltransferase, is reported to catalyze the methylation of lysine residues on histone and non-histone proteins. As a potential target for cancer therapy, there are several SMYD2 inhibitors are reported, LLY-507 as a cell-active inhibitor exhibits submicromolar potency against SMYD2 in several cancer cell lines. To know which structural fragment of LLY-507 is suitable for chem. modification, three sites are chosen for structure-activity relationship studies (SARs). Among our focused library, compounds 43 and 44 with amide link on site C showed reasonably improved potency indicating that modification on this fragment is more flexible and introduction of electrophilic warheads in this position might provide lysine-targeting covalent inhibitors for SMYD2. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 2-Hydroxyphenylboronic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Iron(0)-Catalyzed Transfer Hydrogenative Condensation of Nitroarenes with Alcohols: A Straightforward Approach to Benzoxazoles, Benzothiazoles, and Benzimidazoles》 was written by Putta, Ramachandra Reddy; Chun, Simin; Choi, Seung Hyun; Lee, Seok Beom; Oh, Dong-Chan; Hong, Suckchang. Recommanded Product: 100-55-0 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

The iron-catalyzed hydrogen transfer strategy has been applied to the redox condensation of o-hydroxynitrobenzene with alc., leading to the formation of benzoxazole derivatives A wide range of 2-substituted benzoxazoles were synthesized in good to excellent yields without the addition of an external redox agent. A series of control experiments provided a plausible mechanism. Furthermore, the reaction system was successfully extended to the synthesis of benzothiazoles and benzimidazoles. The results came from multiple reactions, including the reaction of 3-Pyridinemethanol(cas: 100-55-0Recommanded Product: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Recommanded Product: 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dou, Haozhen; Xu, Mi; Wang, Baoyu; Zhang, Zhen; Luo, Dan; Shi, Benbing; Wen, Guobin; Mousavi, Mahboubeh; Yu, Aiping; Bai, Zhengyu; Jiang, Zhongyi; Chen, Zhongwei published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Analogous Mixed Matrix Membranes with Self-Assembled Interface Pathways》.Product Details of 156-87-6 The article contains the following contents:

The implementation of mixed matrix membranes (MMMs) for sub-angstrom scale gas separations remains a grand challenge. Herein, a series of analogous mixed matrix membrane (AMMMs) were constructed via mol.-level hybridization by utilizing a reactive ionic liquid (RIL) as the continuous phase and graphene quantum dots (GQD) as nanofiller for sub-angstrom scale ethylene/ethane (0.416 nm/0.443 nm) separation With a small number of GQDs (3.5 wt%) embedded in GQD/RIL AMMMs, ethylene permeability soared by 3.1-fold, and ethylene/ethane selectivity simultaneously boosted by nearly 60% and reached up to 99.5, which outperformed most previously reported state-of-the-art membranes. Importantly, the interfacial pathway structure was visualized and their self-assembly mechanism was revealed, where the non-covalent interactions between RIL and GQDs induced the local arrangement of IL chains to self-assemble into plenty of compact and superfast interfacial pathways, contributing to the combination of superhigh permeability and selectivity. In the experimental materials used by the author, we found 3-Aminopropan-1-ol(cas: 156-87-6Product Details of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Product Details of 156-87-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Politano, Fabrizio; Sandoval, Arturo Leon; Uranga, Jorge G.; Bujan, Elba I.; Leadbeater, Nicholas E. published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Using experimental and computational approaches to probe an unusual carbon-carbon bond cleavage observed in the synthesis of benzimidazole N-oxides》.Formula: C4H11NO The article contains the following contents:

Exptl. and computational studies was performed in order to investigate an unusual carbon-carbon bond cleavage that occurs in the preparation of certain benzimidazole N-oxides from anilines. The key factor determining the outcome of the reaction was found to be the substituents on the amine functionality of the aniline. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Formula: C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Manandhar, Erendra; Johnson, Ashley D. G.; Watson, William M.; Dickerson, Shelby D.; Sahukhal, Gyan S.; Elasri, Mohamed O.; Fronczek, Frank R.; Cragg, Peter J.; Wallace, Karl J. published an article in 2021. The article was titled 《Detection of ferric ions in a gram-positive bacterial cell: Staphylococcus aureus》, and you may find the article in Journal of Coordination Chemistry.Related Products of 1195-59-1 The information in the text is summarized as follows:

A rhodamine-based chemosensor was synthesized and found to selectively bind ferric ions over other metal ions (Na+, K+, Ca2+, Mg2+, Fe2+, Zn2+, Cd2+, Co2+, Hg2+ Cr3+, Al3+) in an organic-aqueous mixture (CH3CN-MES). Upon addition of ferric ions, the spirolactam ring opens, producing a visual color change and a fluorescence intensity increase, i.e. a turn on optical response at 577 nm is observed The chemosensor coordinates to ferric ions in 1:1 stoichiometry with a calculated Ka = 3.5 × 104 mol dm-3 by fluorescence spectroscopy and a LoD of 27 ppb. The chemosensor was reversible upon addition of the Fe3+ chelator desferrioxamine. One- and two-dimensional NMR experiments with Al3+ ions aided in understanding of the coordination environment of the ferric ion with the chemosensor, which were confirmed by mol. modeling calculations X-ray quality crystals of the chemosensor were obtained, and the solid-state structure is reported. Confocal microscopy was used to detect free ferric ions in Staphylococcus aureus. In the experiment, the researchers used 2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Senthilkumar, Samuthirarajan; Zhong, Wei; Natarajan, Mookan; Lu, Chunxin; Xu, Binyu; Liu, Xiaoming published an article in 2021. The article was titled 《A green approach for aerobic oxidation of benzylic alcohols catalysed by CuI-Y zeolite/TEMPO in ethanol without additional additives》, and you may find the article in New Journal of Chemistry.Computed Properties of C7H7BrO The information in the text is summarized as follows:

An efficient and green protocol for aerobic oxidation of benzylic alcs. in ethanol using CuI-Y zeolite catalysts assisted by TEMPO (TEMPO = 2,2,6,6-tetramethyl-1-piperidine-N-oxyl) as the radical co-catalyst in the presence of atm. air under mild conditions is reported. The CuI-Y zeolite prepared via ion exchange between CuCl and HY zeolite was fully characterized by a variety of spectroscopic techniques including XRD, XPS, SEM, EDX and HRTEM. The incorporation of Cu(I) into the 3D-framework of the zeolite rendered the catalyst with good durability. The results of repetitive runs revealed that in the first three runs, there was hardly a decline in activity and a more substantial decrease in yield was observed afterwards, while the selectivity remained almost unchanged. The loss in activity was attributed to both the formation of CuO and the bleaching of copper into the liquid phase during the catalysis, of which the formation of CuO was believed to be the major contributor since the bleaching loss for each run was negligible (<2%). In this catalytic system, except TEMPO, no other additives were needed, either a base or a ligand, which was essential in some reported catalytic systems for the oxidation of alcs. The aerobic oxidation proceeded under mild conditions (60°C, and 18 h) to quant. and selectively convert a wide range of benzylic alcs. to corresponding aldehydes, which shows great potential in developing green and environmentally benign catalysts for aerobic oxidation of alcs. The system demonstrated excellent tolerance against electron-withdrawing groups on the Ph ring of the alcs. and showed sensitivity to steric hindrance of the substrates, which is due to the confinement of the pores of the zeolite in which the oxidation occurred. Based on the mechanism reported in the literature for homogenous oxidation, a mechanism was analogously proposed for the aerobic oxidation of benzylic alcs. catalyzed by this Cu(I)-containing zeolite catalyst. The experimental part of the paper was very detailed, including the reaction process of (4-Bromophenyl)methanol(cas: 873-75-6Computed Properties of C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Computed Properties of C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts