Month: October 2022

Tian, Sinuo; Yan, Sen; Meng, Zhiyuan; Huang, Shiran; Sun, Wei; Jia, Ming; Teng, Miaomiao; Zhou, Zhiqiang; Zhu, Wentao published the artcile< New insights into bisphenols induced obesity in zebrafish (Danio rerio): Activation of cannabinoid receptor CB1>, Application In Synthesis of 492-62-6, the main research area is metabolome bisphenol tetrabromobisphenol cannabinoid CB1 receptor obesity Danio; Bisphenols; Metabolomic modulations; Molecular structure; PCR array; Zebrafish.

Bisphenols (BPs), as widely used plastic additives, penetrate into our daily lives. BPs are considered endocrine disruptors and could potentially induce obesity. In this study, the effects of bisphenol A (BPA) and tetrabromobisphenol A (TBBPA) on food intake and lipid metabolism in zebrafish were determined Moreover, the impact of BPA and TBBPA on the endocannabinoid system (ECS) of zebrafish was further explored by metabolomics, transcriptomics, and mol. docking anal. Here we show that exposure to BPA and TBBPA at concentrations commonly found in the environment (20, 100, and 500μg/L) led to hyperphagia and obesity in adult male zebrafish. Metabolomics and histopathol. anal. revealed significant lipid accumulation in the liver of zebrafish exposed to BPA and TBBPA. The expression of ECS-related genes, in conjunction with RNA-Seq results, further indicated that BPA and TBBPA increased appetite and induced obesity by activating cannabinoid receptor type 1(CB1). Furthermore, mol. docking revealed that six representative BPs including BPA and TBBPA could bind to the CB1 receptor. Collectively, these findings indicate that CB1 may be a potential target for BPs to induce obesity.

Journal of Hazardous Materials published new progress about Adult, nonmammalian. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 492-62-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Li-Chao; Zhu, Yong-Ming; Zhu, Zhen-Yuan; Xue, Wei; Liu, Chun-Yu; Sun, Hui-Qing; Yue-Yin published the artcile< Chemical structure and effects of antioxidation and against α-glucosidase of natural polysaccharide from Glycyrrhiza inflata Batalin>, Related Products of 3458-28-4, the main research area is Glycyrrhiza antioxidant alpha glucosidase natural polysaccharide free radical scavenger; Antioxidant activity; Glycyrrhiza inflata Batalin; Polysaccharide; Structural characterization; Surface plasmon resonance; α-Glucosidase inhibition.

GIBP, a homogeneous polysaccharide extracted from Glycyrrhiza inflata Batalin with a mol. weight 1.96 x 103 kDa, had a triple helix structure, smooth and sheet-like structure. Comprehensive anal. showed that the main chain of GIBP was composed of α-D-1,4 linked glucose, branch points were composed of α-D-1,3,6 and α-D-1,2,3,6 linked glucoses, and side chains were composed of α-D-1,3 and β-D-1,6 linked galactose, β-L-1,2 linked arabinose, α-D-1,3 and β-D-1,3 mannose. The scavenging abilities of GIBP (3 mg/mL) against DPPH· radical, ·OH radical, O2-· radical and ABTS were 50.75 ± 0.13% and 52.32 ± 0.13, 25.84 ± 0.35% and 44.57 ± 0.15% and it also demonstrated an obvious dose-effect relationship. The inhibitory activity of α-glucosidase showed that the inhibitory effect of GIBP was enhanced with the increase of concentration When the concentration reached 6 mg/mL, the inhibition rate of α-glucosidase activity reached 64.77%. And the ka, kd and KD were 6.472 x 104 1/Ms., 2.934 x 10-3 1/s and 4.534 x 10-8 M.

International Journal of Biological Macromolecules published new progress about Antioxidants. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guan, Zhipeng; Zhu, Shuxiang; Wang, Siyuan; Wang, Huamin; Wang, Siyuan; Zhong, Xingxing; Bu, Faxiang; Cong, Hengjiang; Lei, Aiwen published the artcile< Electrochemical Oxidative Carbon-Atom Difunctionalization: Towards Multisubstituted Imino Sulfide Ethers>, Related Products of 627-27-0, the main research area is electrochem oxidative difunctionalization isocyanide imino sulfide ether stereoselective synthesis; electrochemistry; ethers; isocyanides; radicals; synthetic methods.

Ethers (C-O/S) are ubiquitously found in a wide array of functional mols. and natural products. Nonetheless, the synthesis of imino sulfide ethers, containing an N(sp2)=C(sp2)-O/S fragment, still remains a challenge because of its sensitivity to acid. Developed here in is an unprecedented electrochem. oxidative carbon-atom difunctionalization of isocyanides, providing a series of novel multisubstituted imino sulfide ethers. Under metal-free and external oxidant-free conditions, isocyanides react smoothly with simple and readily available mercaptans and alcs. [e.g., 4-fluorobenzenethiol + Et isocyanoacetate + methanol → (Z)-I (80% isolated)]. Importantly, the procedure exhibited high stereoselectivities, excellent functional-group tolerance, and good efficiency on large-scale synthesis, as well as further derivatization of the products.

Angewandte Chemie, International Edition published new progress about Aromatic thiols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Related Products of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Chunyu; Shin, Myeongcheol; Park, Youngjae; Choi, Byoungyun; Jang, Seokhui; Lim, Chaejin; Yun, Hye Sup; Lee, Im-Soon; Won, So-Yoon; Cho, Kyoung Sang published the artcile< Linalool alleviates Aβ42-induced neurodegeneration via suppressing ROS production and inflammation in fly and rat models of Alzheimer's disease>, Product Details of C10H18O, the main research area is .

Terpenes are vital metabolites found in various plants and animals and known to be beneficial in the treatment of various diseases. Previously, our group identified terpenes that increased the survival of Alzheimer’s disease (AD) model flies expressing human amyloid β (Aβ) and identified linalool as a neuroprotective terpene against Aβ toxicity. Linalool is a monoterpene that is commonly present as a constituent in essential oils from aromatic plants and is known to have anti-inflammatory, anticancer, antihyperlipidemia, antibacterial, and neuroprotective properties. Although several studies have shown the beneficial effect of linalool in AD animal models, the mechanisms underlying the beneficial effect of linalool on AD are yet to be elucidated. In the present study, we showed that linalool intake increased the survival of the AD model flies during development in a dosedependent manner, while the survival of wild-type flies was not affected even at high linalool concentrations Linalool also decreases Aβ-induced apoptosis in eye disks as well as the larval brain. Moreover, linalool intake was found to reduce neurodegeneration in the brain of adult AD model flies. However, linalool did not affect the total amount of Aβ42 protein or Aβ42 aggregation. Rather, linalool decreased Aβ-induced ROS levels, oxidative stress, and inflammatory response in the brains of AD model flies. Furthermore, linalool attenuated the induction of oxidative stress and gliosis by Aβ1-42 treatment in the rat hippocampus. Taken together, our data suggest that linalool exerts its beneficial effects on AD by reducing Aβ42-induced oxidative stress and inflammatory reactions.

Oxidative Medicine and Cellular Longevity published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Afewerki, Samson; Palo-Nieto, Carlos; Cordova, Armando published the artcile< Efficient Heterogeneous Palladium-Catalyzed Transfer Hydrogenolysis of Benzylic Alcohols by Formic Acid>, Product Details of C19H16O, the main research area is benzylic alc formic acid palladium catalyst chemoselective transfer hydrogenolysis; alkyl benzene preparation.

An efficient heterogeneous palladium-catalyzed transfer hydrogenolysis of primary, secondary and tertiary benzylic alcs. using formic acid as hydrogen source was developed. The resulting hydrocarbon products were obtained in excellent yields. Moreover, the system exhibited high chemoselectivity, reacting only with the hydroxy groups in the presence of other functional groups and excellent recyclability.

Synthesis published new progress about Alkylbenzenes Role: SPN (Synthetic Preparation), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Product Details of C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bharate, Sandip B.; Mudududdla, Ramesh; Bharate, Jaideep B.; Battini, Narsaiah; Battula, Satyanarayana; Yadav, Rammohan R.; Singh, Baldev; Vishwakarma, Ram A. published the artcile< Tandem one-pot synthesis of flavans by recyclable silica-HClO4 catalyzed Knoevenagel condensation and [4 + 2]-Diels-Alder cycloaddition>, Product Details of C8H6O5, the main research area is flavan preparation Knoevenagel condensation Diels Alder silica perchloric acid.

An efficient one-pot multi-component synthesis of flavans, e.g., I, using perchloric acid supported on silica as a recyclable heterogeneous catalyst has been described. This is the first report of direct one-step construction of a flavan skeleton from a phenolic precursor, e.g., II. The method involves a Knoevenagel-type condensation leading to in situ formation of transient O-quinone methide which further undergoes [4 + 2]-Diels-Alder cycloaddition with styrene, e.g., 4-H2C:CHC6H4CMe3, to yield a flavan skeleton. The method provides easy access to a wide range of bio-active natural products viz. flavonoids, anthocyanins and catechins.

Organic & Biomolecular Chemistry published new progress about Diels-Alder reaction. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Product Details of C8H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dull, Ana-Maria; Moga, Marius Alexandru; Dimienescu, Oana Gabriela; Sechel, Gabriela; Burtea, Victoria; Anastasiu, Costin Vlad published the artcile< Therapeutic approaches of resveratrol on endometriosis via anti-inflammatory and anti-angiogenic pathways>, Electric Literature of 501-36-0 , the main research area is review endometriosis resveratrol anti inflammation angiogenic therapeutics; anti-inflammatory; cytokines; endometriosis; inflammatory disease; resveratrol.

A review. Endometriosis represents a severe gynecol. pathol., defined by implantation of endometrial glands and stroma outside the uterine cavity. This pathol. affects almost 15% of women during reproductive age and has a wide range of consequences. In affected women, infertility has a 30% rate of prevalence and endometriosis implants increase the risk of ovarian cancer. Despite long periods of studies and investigations, the etiol. and pathogenesis of this disease still remain not fully understood. Initially, endometriosis was related to retrograde menstruation, but new theories have been launched, suggesting that chronic inflammation can influence the development of endometriosis because inflammatory mediators have been identified elevated in patients with endometriosis, specifically in the peritoneal fluid. The importance of dietary phytochems. and their effect on different inflammatory diseases have been highlighted, and nowadays more and more studies are focused on the anal. of nutraceuticals. Resveratrol is a phytoestrogen, a natural polyphenolic compound with antiproliferative and anti-inflammatory actions, found in many dietary sources such as grapes, wine, peanuts, soy, berries, and stilbenes. Resveratrol possesses a significant anti-inflammatory effect via inhibition of prostaglandin synthesis and it has been proved that resveratrol can exhibit apoptosis-inducing activities. From the studies reviewed in this paper, it is clear that the anti-inflammatory effect of this natural compound can contribute to the prevention of endometriosis, this phenolic compound now being considered a new innovative drug in the prevention and treatment of this disease.

Molecules published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Du, Wenchao; Liu, Xing; Zhao, Lijuan; Xu, Yanwen; Yin, Ying; Wu, Jichun; Ji, Rong; Sun, Yuanyuan; Guo, Hongyan published the artcile< Response of cucumber (Cucumis sativus) to perfluorooctanoic acid in photosynthesis and metabolomics>, Synthetic Route of 87-73-0, the main research area is Cucumis perfluorooctanoic acid photosynthesis metabolome; Amino acid; Bioaccumulation; Chlorophyll; PFOA; Phenolic.

A mechanistic understanding of perfluorooctanoic acid (PFOA) toxicity to plants is essential for future risk assessment of PFOA in agricultural soil. In this study, soil-grown cucumber (Cucumis sativus) was exposed to 0, 0.2, and 5 mg/kg of PFOA for 60 days. At harvest, contaminant accumulation, cucumber biomass, photosynthesis profiles and metabolites were measured. Results showed that PFOA depressed cucumber biomass and accumulated highest in leaves. Photosynthesis anal. revealed that PFOA at both doses reduced the chlorophyll contents and net photosynthesis rate of cucumber leaves. Gas chromatog.-mass spectrometry-based non-targeted metabolomics revealed that PFOA induced metabolic reprogramming in cucumber leaves, including up-regulation of phenols (at 0.2 and 5 mg/kg) and down-regulation of amino acids (at 5 mg/kg), indicating disrupted nitrogen and carbon metabolism Results revealed how PFOA represses plant growth by down-regulating photosynthetic pigments and disturbing the metabolism of carbohydroxides, phenols and amino acids. These findings provide valuable information for understanding the mol. mechanisms involved in plant responses to PFOA-induced stress.

Science of the Total Environment published new progress about Air pollution, carbon dioxide. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Synthetic Route of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gou, Bo-Bo; Yang, Sen; Sun, Huai-Ri; Jian, Qing-Song; Sharif, Atif; Zhou, Ling; Chen, Jie published the artcile< Scandium Triflate Catalyzed Tandem Transfer Hydrogenation and Cyclization Reaction of o-Aminobenzaldehydes and o-Aminoacetophenone with Alcohols>, Formula: C4H8O, the main research area is benzoxazine preparation; aminobenzaldehyde alc tandem hydrogenation cyclization reaction scandium triflate catalyst; alc aminoacetophenone tandem hydrogenation cyclization reaction scandium triflate catalyst.

An effective Sc-catalyzed transfer hydrogenation and cyclization tandem reaction has been achieved. This process showed excellent functional group compatibility and good yields. A variety of benzoxazines I (R = H, Me; R1 = H, Me, Et; R2 = Me, Ph, naphthalen-1-yl, thiophen-2-ylmethyl, etc.; R1R2 = -(CH2)5-; R3 = H, F, Cl, Me, Br; R4 = H, Me; R5 = H, Me, Cl, Br) were produced with primary or secondary alcs. R2(R3)CH2OH as a hydrogen source. Furthermore, the utility of this newly developed protocol is demonstrated through scaled-up experiment, late-stage modification, and preliminary exploration of enantioselective synthesis.

Journal of Organic Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent) (o-amino). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Rongzhou; Qi, Jipeng; Yue, Yuancheng; Lian, Zhe; Xiao, Haibin; Zhuo, Shuping; Xing, Lingbao published the artcile< Ambient-pressure hydrogenation of ketones and aldehydes by a metal-ligand bifunctional catalyst [Cp*Ir(2,2'-bpyO)(H2O)] without using base>, Quality Control of 403-41-8, the main research area is secondary alc preparation green chem; ketone hydrogenation bifunctional iridium complex catalyst; primary alc preparation green chem; aldehyde hydrogenation bifunctional iridium complex catalyst.

An efficient catalytic system for hydrogenation of ketones R1C(O)R2 [R1 = Me, 3,4-dichlorophenyl, 2-naphthyl, pyridin-2-yl, etc.; R2 = Me, Pr, hexyl; R1R2 = -(CH2)5-] and aldehydes R3CHO (R3 = nonyl, cyclohexyl, 4-cyanophenyl, pyridin-2-yl, etc.) using a Cp*Ir complex [Cp*Ir(2,2′-bpyO)(H2O)] bearing a bipyridine-based functional ligand as catalyst has been developed. A wide variety of secondary and primary alcs. (R1)(R2)CHOH and R3CH2OH resp. was synthesized by the catalyzed hydrogenation of ketones and aldehydes under facile atm.-pressure without a base. The catalyst also displays an excellent chemoselectivity towards other carbonyl functionalities and unsaturated motifs. This catalytic system exhibits high activity for hydrogenation of ketones and aldehydes with H2 gas.

Tetrahedron published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Quality Control of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts