Month: October 2022

Beni, Ryan; Boadi, William; Karim, Kaleh; Alnakhli, Jawzah; Alhamed, Samiyah published the artcile< Synthesis and antiproliferative activities of triphenylmethanol conjugates of leuprorelin>, Formula: C19H16O, the main research area is leuprorelin triphenylmethanol conjugate antiproliferative invasive ductal prostate carcinoma adipocyte.

Leuprorelin (LEP) is an FDA drug for breast cancer and prostate cancer treatment. There are several reported adverse effects such as transient hypertension, excessive salivation, and increased dysuria during treatment with LEP. In this study, the efficacy and toxicity of LEP were modified by using a drug delivery system to adjust the physicochem. properties. In this regard, Leuprorelin conjugates of triphenylmethanol derivatives (TPMs) were synthesized as prodrugs. Comparative antiproliferative assays showed that LEP-TPMs conjugates had significantly higher antiproliferative activities than the corresponding non-covalent phys. mixtures of the TPMs and LEP against human invasive ductal carcinoma (BT549), human prostate carcinoma (PC3), human lung cancer (A549) and mouse pre-adipocytes (3T3-L1) cells.

Open Journal of Medicinal Chemistry published new progress about Adipocyte, preadipocyte. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Formula: C19H16O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moeini, Nazanin; Molaei, Somayeh; Ghadermazi, Mohammad published the artcile< Selective oxidation of sulfides and synthesis of 5-substituted 1H-tetrazoles on Ce (III) immobilized CoFe2O4 as a magnetically separable, highly active, and reusable nanocatalyst>, Safety of 2-(Phenylthio)ethanol, the main research area is cobalt iron oxide nanocatalyst cerium immobilized amino glycol preparation; tetrazole green preparation; nitrile sodium azide cobalt iron oxide nanocatalyst cerium immobilized; sulfoxide green preparation; sulfide oxidation cobalt iron oxide nanocatalyst cerium immobilized.

Reactions of CoFe2O4 magnetic nanoparticles supported ligands, 2-amino-2-methyl-1,3-propanediol (Amino glycol), with cerium salts provided the resp. anchored complex CoFe2O4 @Amino glycol/Ce. The nanocatalyst was characterized perfectly using thermogravimetric analyzes, FT-IR spectroscopy, SEM, energy-dispersive X-ray inductively coupled plasma optical emission spectroscopy vibrational sample magnetometry and powder X-ray diffraction. CoFe2O4 magnetic nanoparticles supported ligands with cerium salts afforded active catalysts for the synthesis of 5-substituted 1H-tetrazoles I [R = Ph, 2-ClC6H4, Bn, etc.] via reaction of nitriles and sodium azide/oxidation of sulfides RSR1 [R = Ph, n-Pr, Et, etc.; R1 = Me, Bn, Ph, etc.] using Me Ph sulfide with H2O2 as oxidant at mild reaction conditions in the green medium under optimized conditions. The ligand and metal atom identity influenced the catalytic activity of the nanocatalyst. The immobilized complexes were easily collected via an external magnetic field and further reused at least 6 times without significant loss of catalytic activity and selectivity.

Research on Chemical Intermediates published new progress about Green chemistry. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Safety of 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mandler, Michael D.; Degnan, Andrew P.; Zhang, Shasha; Aulakh, Darpandeep; Georges, Ketleine; Sandhu, Bhupinder; Sarjeant, Amy; Zhu, Yeheng; Traeger, Sarah C.; Cheng, Peter T.; Ellsworth, Bruce A.; Regueiro-Ren, Alicia published the artcile< Structural and Thermal Characterization of Halogenated Azidopyridines: Under-Reported Synthons for Medicinal Chemistry>, COA of Formula: C9H8O, the main research area is halogenated azidopyridine preparation structure thermal property click reaction; safety shock sensitivity energetic material.

Owing to their participation in Click reactions, bifunctional azides are valuable intermediates in the preparation of medicines and biochem. tool compounds Despite the privileged nature of pyridines among pharmaceutical scaffolds, reports of the synthesis and characterization of azidopyridines bearing a halogen substituent for further elaboration are almost completely unknown in the literature. As azidopyridines carry nearly equal numbers of nitrogen and carbon atoms, we hypothesized that safety concerns limited the application of these useful bifunctional building blocks in medicinal and biol. chem. To address this concern, we prepared and characterized nine azidopyridines bearing a single fluorine, chlorine, or bromine atom. All were examined by differential scanning calorimetry (DSC), in which they demonstrated exotherms of 228-326 kJ/mol and onset temperatures between 119 and 135°C. Selected azidopyridines were advanced to mech. stress testing, in which impact sensitivity was noted for one regioisomer of C5H3FN4. The utility of these versatile intermediates was demonstrated through their use in a variety of Click reactions and the diversification of the halogen handles.

Organic Letters published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, COA of Formula: C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cook, Ian; Leyh, Thomas S. published the artcile< The N-Terminus of Human Sulfotransferase 2B1b-a Sterol-Sensing Allosteric Site>, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol, the main research area is sulfotransferase SULT2B1b allosteric site allostere quercetin oxysterol.

Among human cytosolic sulfotransferases, SULT2B1b is highly specific for oxysterols-oxidized cholesterol derivatives, including nuclear-receptor ligands causally linked to skin and neurodegerative diseases, cancer and atherosclerosis. Sulfonation of signaling oxysterols redirects their receptor-binding functions, and controlling these functions is expected to prove valuable in disease prevention and treatment. SULT2B1b is distinct among the human SULT2 isoforms by virtue of its atypically long N-terminus, which extends 15 residues beyond the next longest N-terminus in the family. Here, in silico studies are used to predict that the N-terminal extension forms an allosteric pocket and to identify potential allosteres. One such allostere, quercetin, is used to confirm the existence of the pocket and to demonstrate that allostere binding inhibits turnover. The structure of the pocket is obtained by positioning quercetin on the enzyme, using spin-label-triangulation NMR, followed by NMR distance-constrained mol. dynamics docking. The model is confirmed using a combination of site-directed mutagenesis and initial-rate studies. Stopped-flow ligand-binding studies demonstrate that inhibition is achieved by stabilizing the closed form of the enzyme active-site cap, which encapsulates the nucleotide, slowing its release. Finally, endogenous oxysterols are shown to bind to the site in a highly selective fashion-one of the two immediate biosynthetic precursors of cholesterol (7-dehydrocholesterol) is an inhibitor, while the other (24-dehydrocholesterol) is not. These findings provide insights into the allosteric dialogue in which SULT2B1b participates in in vivo and establishes a template against which to develop isoform-specific inhibitors to control SULT2B1b biol.

Biochemistry published new progress about Allosterism. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Recommanded Product: (3S,9S,10R,13R,14R,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sandu, Mariya P.; Sidelnikov, Vladimir S.; Geraskin, Andrej A.; Chernyavskii, Aleksandr V.; Kurzina, Irina A. published the artcile< Influence of the method of preparation of the Pd-Bi/Al2O3 catalyst on catalytic properties in the reaction of liquid-phase oxidation of glucose into gluconic acid>, Related Products of 87-73-0, the main research area is palladium bismuth alumina catalyst liquid oxidation glucose gluconic acid.

Gluconic acid and its derivatives are extensively used in pharmaceutical, food, textile, and pulp and paper branches of industry during production of food additives, cleansers, medicinal drugs, stabilizers, etc. To obtain gluconic acid, the method of conversion of glucose into gluconic acid by mol. oxygen in the presence of solid catalysts is promising. The process of obtaining Pd and bimetallic nanoparticles Pd-Bi, coated on Al2O3, has been considered in the work. Samples were prepared by combined and successive impregnation of the Al2O3 support using metalloorg. precursors Pd(acac)2, Bi(ac)3, and dissolved in an organic solvent (acetic acid), followed by the removal of excess solvent. To achieve the formation of Pd and bimetallic nanoparticles Pd-Bi on the substrate surface, the synthesized samples were subjected to thermal decomposition sequentially in the atm. of Ar, O2, and H2. The surface of the obtained catalysts was studied by a combination of physicochem. methods of anal. The catalysts were analyzed in the reaction of liquid phase oxidation of glucose. The best results are achieved in the presence of the catalyst obtained by combined impregnation.

Catalysts published new progress about Binding energy. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Related Products of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jelicic, Mario-Livio; Brusac, Edvin; Klaric, Daniela Amidzic; Nigovic, Biljana; Turk, Niksa; Mornar, Ana published the artcile< A chromatographic approach to development of 5-aminosalicylate/folic acid fixed-dose combinations for treatment of Crohn's disease and ulcerative colitis>, Quality Control of 6054-98-4, the main research area is chromatog aminosalicylate folic acid treatment Crohn disease ulcerative colitis.

Medication adherence is an important factor in inflammatory bowel disease therapy, which includes regular supplementation of malabsorbed vitamins. Absorption of folic acid is limited due to the damaging of the gastrointestinal tract, which can increase the chances to develop megaloblastic anemia and colorectal cancer. In this work, 5-aminosalicylates (mesalazine, balsalazide, sulfasalazine and olsalazine) and folic acid were characterized regarding their pharmacokinetic related properties (hydrophobicity, phospholipid and plasma protein binding) using the biomimetic chromatog. approach. Despite the high binding percentage of 5-aminosalicylates for human serum albumin (> 61.44%), results have shown that folic acid binding to human serum albumin protein is far greater (69.40%) compared to alpha 1-acid-glycoprotein (3.45%). Frontal anal. and zonal elution studies were conducted to provide an insight into the binding of folic acid to human serum albumin and potential competition with 5-aminosalicylates. The anal. method for the simultaneous determination of assay in proposed fixed-dose combinations was developed and validated according to ICH Q2 (R1) and FDA method validation guidelines. Separation of all compounds was achieved within 16 min with satisfactory resolution (Rs > 3.67) using the XBridge Ph column (150 x 4.6 mm, 3.5μm). High linearity (r > 0.9997) and precision (RSD < 2.29%) was obtained, while all recoveries were within the regulatory defined range by British (100.0 ± 5.0%) and USP (100.0 ± 10.0%). Scientific Reports published new progress about Absorption. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Quality Control of 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bai, Renren; Zhu, Junlong; Bai, Ziqiang; Mao, Qing; Zhang, Yingqian; Hui, Zi; Luo, Xinyu; Ye, Xiang-Yang; Xie, Tian published the artcile< Second generation β-elemene nitric oxide derivatives with reasonable linkers: potential hybrids against malignant brain glioma>, Computed Properties of 699-12-7, the main research area is beta elemene nitric oxide malignant brain glioma antitumor; NO donor; anti-tumour; malignant glioma; natural product; β-Elemene.

Elemene is a second-line broad-spectrum anti-tumor drug that has been used in China for more than two decades. However, its main anti-tumor ingredient, β-elemene, has disadvantages, including excessive lipophilicity and relatively weak anti-tumor efficacy. To improve the anti-tumor activity of β-elemene, based on its minor mol. weight character, we introduced furoxan nitric oxide (NO) donors into the β-elemene structure and designed six series of new generation β-elemene NO donor hybrids. The synthesized compounds could effectively release NO in vitro, displayed significant anti-proliferative effects on U87MG, NCI-H520, and SW620 cell lines. In the orthotopic glioma model, compound significantly and continuously suppressed the growth of gliomas in nude mice, and the brain glioma of the treatment group was markedly inhibited (>90%). In short, the structural fusion design of NO donor and β-elemene is a feasible strategy to improve the in vivo anti-tumor activity of β-elemene.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about Amidation. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Computed Properties of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Goclik, Lisa; Offner-Marko, Lisa; Bordet, Alexis; Leitner, Walter published the artcile< Selective hydrodeoxygenation of hydroxyacetophenones to ethyl-substituted phenol derivatives using a FeRu@SILP catalyst>, Synthetic Route of 403-41-8, the main research area is ionic liquid supported iron ruthenium nanoparticle catalyst preparation; ethyl substituted phenol preparation; hydroxyacetophenone seelective deoxygenation.

The selective hydrodeoxygenation of hydroxyacetophenone derivatives is achieved opening a versatile pathway for the production of valuable substituted ethylphenols from readily available substrates. Bimetallic iron ruthenium nanoparticles immobilized on an imidazolium-based supported ionic liquid phase (Fe25Ru75@SILP) show high activity and stability for a broad range of substrates without acidic co-catalysts.

Chemical Communications (Cambridge, United Kingdom) published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Synthetic Route of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jeandet, Philippe; Sobarzo-Sanchez, Eduardo; Silva, Ana Sanches; Clement, Christophe; Nabavi, Seyed Fazel; Battino, Maurizio; Rasekhian, Mahsa; Belwal, Tarun; Habtemariam, Solomon; Koffas, Mattheos; Nabavi, Seyed Mohammad published the artcile< Whole-cell biocatalytic, enzymatic and green chemistry methods for the production of resveratrol and its derivatives>, Application of C14H12O3, the main research area is Biocatalysis; Enzymatic transformation; Green chemistry; Laccases; Peroxidases; Resveratrol; Resveratrol glucosides; Resveratrol oligomers; Stilbenes; Whole cell biocatalysis.

Resveratrol and the biosynthetically related stilbenes are plant secondary metabolites with diverse pharmacol. effects. The versatile functions of these compounds in plant defense mechanisms as phytoalexins on one hand, and in human health as potential pharmaceutical agents on the other, have attracted lots of interest in recent years to understand their biosynthetic pathways and their biol. properties. Because of difficulties in obtaining resveratrol and its glucosylated derivatives as well as oligomeric forms in sufficient amounts for evaluation of their activity by plant sourcing or total synthesis, biotechnol. may provide a competitive approach for the large-scale and low cost production of biol. active stilbenes. Addnl., one major limitation in the use of resveratrol and related aglycon derivatives as therapeutic agents is associated with their inherent poor aqueous solubility and low bioavailability. This article examines approaches for the synthesis of potential pharmacol. resveratrol derivatives in vivo by exploiting whole microorganisms, enzymic and biocatalytic approaches allowing their full utilization for medicine, food and cosmetic applications. These methods also have the advantage of enabling the one-step production of stilbene compounds, compared to the time-consuming and environmentally unfriendly procedures used for their total synthesis or their extraction from plants. Increasing the desired products yield and biol. activity through glucosylation (β-D-glucosides vs. α-D-glucosides) and oligomerization methodologies of resveratrol including green chem. methods in organic solvent-free media are discussed as well.

Biotechnology Advances published new progress about 501-36-0. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Duman, Muhammed; Mulet, Magdalena; Altun, Soner; Saticioglu, Izzet Burcin; Gomila, Margarita; Lalucat, Jorge; Garcia-Valdes, Elena published the artcile< Pseudomonas piscium sp. nov., Pseudomonas pisciculturae sp. nov., Pseudomonas mucoides sp. nov. and Pseudomonas neuropathica sp. nov. isolated from rainbow trout>, Product Details of C6H10O8, the main research area is Pseudomonas species isolation rainbow trout; Pseudomonas; aquaculture; genome analysis; multi-locus sequence analysis; rainbow trout.

Six Gram neg., motile bacteria were isolated from rainbow trout (Oncorhynchus mykiss). The 16S rRNA sequence similarity values grouped them in the Pseudomonas mandelii (strains P49, P50T, 154aT and P154b), Pseudomonas fluorescens (strain P115T) and Pseudomonas koreensis (strain P155T) phylogenetic subgroups in the genus Pseudomonas. The DNA G + C content ranged from 58.5 to 60 mol%. The strains were characterized phenotypically using API 20NE and Biolog GENIII tests, and chemotaxonomically by their whole-cell MALDI-TOF MS protein profiles and fatty acid contents. Multi-locus sequence anal. with four housekeeping gene sequences (rpoD, rpoB, gyrB and 16S rRNA) together with genome comparisons by average nucleotide identity and genome-to-genome distance calculations were performed. Results showed that the similarity values of these strains to known species type strains were lower than the thresholds established for species in the genus Pseudomonas. Based on these data, we concluded that strains P49, P50T, P115T, P154aT, P154b and P155T belonged to four novel species. The names proposed are: Pseudomonas piscium sp. nov. for strains P49 and P50T with P50T (= CECT 30175T = CCUG 74871T) as the type strain; Pseudomonas pisciculturae sp. nov. for strain P115T (CECT 30173T = CCUG 74873T); Pseudomonas mucoides sp. nov. for strains P154aT and P154b with P154aT (= CECT 30177T = CCUG 74874T) as the type strain; and Pseudomonas neuropathica sp. nov. for strain P155T (= CECT 30178T = CCUG 74875T).

International Journal of Systematic and Evolutionary Microbiology published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Product Details of C6H10O8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts