Month: October 2022

Huang, Dan-Dan; Shi, Guangjiang; Jiang, Yaping; Yao, Chao; Zhu, Chuanlin published the artcile< A review on the potential of Resveratrol in prevention and therapy of diabetes and diabetic complications>, Electric Literature of 501-36-0, the main research area is review resveratrol antidiabetic agent diabetes mellitus; Anti-diabetes; Anti-inflammatory; Anti-oxidant; Diabetic complications; Hypoglycemic effect; Resveratrol.

A review. Diabetes mellitus (DM) is a major world health problem and one of the most studied diseases, which are highly prevalent in the whole world, it is frequently associated with severe clin. complications, such as diabetic cardiomyopathy, nephropathy, retinopathy, neuropathy etc. Scientific research is continuously casting about for new monomer mols. from Chinese herbal medicine that could be invoked as candidate drugs for fighting against diabetes and its complications. Resveratrol (RES), a polyphenol phytoalexin, possesses diverse biochem. and physiol. actions, including antiplatelet, estrogenic, and anti-inflammatory properties. It is recently gaining scientific interest for RES in controlling blood sugar and fighting against diabetes and its complications properties in various types of diabetic models. These beneficial effects seem to be due to the multiple actions of RES on cellular functions, which make RES become a promising mol. for the treatment of diabetes and diabetic complications. Here, we review the mechanism of action and potential therapeutic use of RES in prevention and mitigation of these diseases in recent ten years to provide a reference for further research and development of RES.

Biomedicine & Pharmacotherapy published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Knoefel, Peter K.; Kraft, Robert P. Jr.; Knight, Robert D.; Moore, Susan K. published the artcile< Sodium versus mmeglumine diatrizoate in excretory urography>, Formula: C7H18ClNO5, the main research area is urinary excretion sodium meglumine diatrizoate; electrolyte excretion urine diatrizoate.

The i.v. injection of mannitol [69-65-8], Na diatrizoate (I) [737-31-5] meglumine diatrizoate (II) [131-49-7] or meglumine hydrochloride [35564-86-4] produced diuresis approaching a steady-state in anesthetized dogs. During this period the apparent volumes of distribution of meglumine and diatrizoate were similar and were greater than that of insulin. The plasma concentration, renal clearance, and the rate of urinary excretion were the same for meglumine and diatrizoate. Excretion of urine and urinary electrolytes was greater after II than I or meglumine-HCl. Urinary concentration of diatrizoate was greater after I than II. This difference appears to result from the influence of the 2 impermeant ions on the excretion of other ions. Single-dose experiments revealed no such difference between I and II due to errors arising from collection of urine from the bladder.

Investigative Radiology published new progress about Urinary system. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Formula: C7H18ClNO5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wan, Qijuan; Wu, Liqun; Yang, Qiuhua; Lin, Mao; Guo, Songlin published the artcile< First identification and pathogenicity study of Vibrio harveyi isolated from diseased American eel (Anguilla rostrata) cultivated in freshwater>, Name: D-Glucosaccharic acid, the main research area is Anguilla rostrata disease freshwater Vibrio harveyi isolation pathogenicity.

Diseases caused by Vibrio harveyi in marine organisms have been generally reported in aquaculture, but there has been no reported V. harveyi infection in fish cultivated in freshwater. Herein, we isolated 3 strains of V. harveyi from diseased American eels (Anguilla rostrata) cultivated in freshwater and subsequently confirmed the virulence of V. harveyi and the extracellular product (ECP). The three isolates were identified as V. harveyi based on phenotypic features and homol. of 16S rDNA and 3 house-keeping genes (HKGs). Exptl. infection revealed that V. harveyi and ECP were highly pathogenic to American eels, and the median LDs (LD50) were 1.67 x 103 cfu/g and 7.29μg/g body weight, resp. Moreover, our antibiotic susceptibility test showed that V. harveyi was susceptible to 16 of 20 antibiotics using the VITEK system of Merieux. Furthermore, liver and kidney samples were collected for paraffin sectioning, stained with haematoxylin-eosin (H & E) and Periodic Acid-Schiff (PAS). H & E staining results revealed hepatocyte atrophy and necrosis, hepatic intercellular hemorrhage and intrahepatic venous thrombosis, while the kidney was characterized by renal tubular epithelial cell swelling and renal interstitial haematopoietic cell loss. Interestingly, glycogen deposition was more obvious in the kidney compared with the liver after PAS staining. Cultivated eel infected by V. harveyii was reported for the first time, and the results of this study provide a valuable reference for further prevention and control of fish diseases caused by V. harveyi.

Aquaculture Research published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Qin; Lin, Shang; Fu, Yuan; Nie, Xi-Rui; Liu, Wen; Su, Yan; Han, Qiao-Hong; Zhao, Li; Zhang, Qing; Lin, De-Rong; Qin, Wen; Wu, Ding-Tao published the artcile< Effects of extraction methods on the physicochemical characteristics and biological activities of polysaccharides from okra (Abelmoschus esculentus)>, Related Products of 3458-28-4, the main research area is Abelmoschus hot water extraction physicochem antioxidant polysaccharide; Antioxidant activity; Binding properties; Enzyme inhibition; Extraction method; Okra polysaccharides.

The impacts of three extraction techniques, including hot water extraction (HWE), pressurized water extraction (PWE), and microwave assisted extraction (MAE), on the physicochem. characteristics, antioxidant activities, in vitro binding properties, and in vitro inhibitory activities on α-amylase and α-glucosidase of okra polysaccharides (OPPs) were investigated and compared. The extraction yields, constituent monosaccharides, and FT-IR spectra of OPP-W, OPP-P, and OPP-M extracted by HWE, PWE, and MAE, resp., were similar. However, their mol. weights, intrinsic viscosities, uronic acids, and degree of esterification were different. Furthermore, results showed that OPP-W, OPP-P, and OPP-M exhibited remarkable antioxidant activities, binding capacities, and inhibitory activities on α-amylase and α-glucosidase. Indeed, the antioxidant activities of OPP-W were significantly lower than those of OPP-M and OPP-P, which might be attributed to the low mol. weights and high contents of unmethylated galacturonic acid of OPP-P and OPP-M. However, the binding capacities and inhibitory activities on α-amylase and α-glucosidase of OPP-W and OPP-P were similar, but significantly higher than those of OPP-M, which might be attributed to the low mol. weights of OPP-M. Results suggested that the PWE method could be a good potential technique for the extraction of OPPs with high bioactivities for industrial applications.

International Journal of Biological Macromolecules published new progress about Abelmoschus esculentus. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xie, Fan; Seifert, Nathan A.; Heger, Matthias; Thomas, Javix; Jager, Wolfgang; Xu, Yunjie published the artcile< The rich conformational landscape of perillyl alcohol revealed by broadband rotational spectroscopy and theoretical modelling>, Recommanded Product: (S)-(4-(Prop-1-en-2-yl)cyclohex-1-en-1-yl)methanol, the main research area is perillyl alc conformer conformation internal rotation rotational spectra.

The rotational spectrum of perillyl alc., a naturally occurring, chiral, dietary monoterpene, was investigated using a chirped pulse Fourier transform microwave spectrometer and a cavity-based Fourier transform microwave spectrometer. To aid the assignment of the dense chirped pulse spectrum obtained, extensive theor. conformational searches were carried out. In one approach, several one and two-dimensional scans along three dihedral angles associated with the rotational motions of the -OH, -CH2OH, and -C(CH2)CH3 groups were performed. These scans, combined with the equatorial and axial positions of the -C(CH2)CH3 group, resulted in 54 conformers. The same conformers were identified in the second approach where a semi-classical conformational search code was used. The relative stabilities of the conformers and the interconversion barriers among them were explored extensively at the DFT B3LYP-D3(BJ)/def2-TZVP and B3LYP-D3(BJ)/6-311++G(2d,p), as well as local MP2/aug-cc-pVQZ levels of theory, and 12 conformers were ultimately identified as possibly observable candidates in a mol. jet expansion. Rotational spectra of eight out of the 12 candidates were observed exptl. and analyzed. The non-observation of the remaining four conformers may be attributed to their low abundances. The study points out the importance of identifying all conformers of relevant abundance, even those which could not be detected exptl., in order to properly benchmark the theor. relative stabilities with the exptl. ones. A comprehensive study of the conformational distribution of perillyl alc. contributes to our understanding of its structural properties which may influence its functions.

Physical Chemistry Chemical Physics published new progress about Conformation. 18457-55-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H16O, Recommanded Product: (S)-(4-(Prop-1-en-2-yl)cyclohex-1-en-1-yl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rybchyn, Mark S.; Abboud, Myriam; Puglisi, David A.; Gordon-Thomson, Clare; Brennan-Speranza, Tara C.; Mason, Rebecca S.; Fraser, David R. published the artcile< Skeletal muscle and the maintenance of vitamin D status>, HPLC of Formula: 434-16-2, the main research area is review vitamin D skeletal muscle; muscle; parathyroid hormone; vitamin D; vitamin D-binding protein.

A review. Vitamin D, unlike the micronutrients, vitamins A, E, and K, is largely obtained not from food, but by the action of solar UV light on its precursor, 7-dehydrocholesterol, in skin. With the decline in UV light intensity in winter, most skin production of vitamin D occurs in summer. Since no defined storage organ or tissue has been found for vitamin D, it has been assumed that an adequate vitamin D status in winter can only be maintained by oral supplementation. Skeletal muscle cells have now been shown to incorporate the vitamin D-binding protein (DBP) from blood into the cell cytoplasm where it binds to cytoplasmic actin. This intracellular DBP provides an array of specific binding sites for 25-hydroxyvitamin D (25(OH)D), which diffuses into the cell from the extracellular fluid. When intracellular DBP undergoes proteolytic breakdown, the bound 25(OH)D is then released and diffuses back into the blood. This uptake and release of 25(OH)D by muscle accounts for the very long half-life of this metabolite in the circulation. Since 25(OH)D concentration in the blood declines in winter, its cycling in and out of muscle cells appears to be upregulated. Parathyroid hormone is the most likely factor enhancing the repeated cycling of 25(OH)D between skeletal muscle and blood. This mechanism appears to have evolved to maintain an adequate vitamin D status in winter.

Nutrients published new progress about Cytoplasm. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, HPLC of Formula: 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Zhen; Wei, Yin; Shi, Min published the artcile< A concise method for cyclic gem-difluoroacyl scaffolds via visible-light-mediated redox-neutral cascade radical cyclization of alkenes>, Application of C4H8O, the main research area is cyclic gem difluoroacyl arene preparation; bromodifluoroacyl alkene redox neutral cascade radical cyclization photoredox catalysis.

In this paper, a series of diverse alkenes were engaged in radical tandem cyclization initiated by a CF2 radical precursor via photoredox catalysis, affording various cyclic gem-difluoroacyl arenes in good to excellent yields. This photo-induced protocol features a redox-neutral process to access a variety of gem-difluoroacyl arenes with a broad substrate scope and the structural motifs are important in pharmaceutical and agrochem. products. The mechanistic paradigm has been proposed on the basis of control and Stern-Volmer anal. experiments

Catalysis Science & Technology published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cheng, Yuan; Qin, Shu-kui; Li, Jin; Dai, Guang-hai; Shen, Bai-yong; Ying, Jie-er; Ba, Yi; Liang, Han; Wang, Xin-bo; Xu, Ye; Zhou, Lin; Ding, Ke-feng; Qin, Yan-ru; Yang, Shu-jun; Guan, Wen-xian; Zheng, Hui; Wang, Qian; Song, Hang; Zhu, Yan-ping published the artcile< A multicenter clinical study: personalized medication for advanced gastrointestinal carcinomas with the guidance of patient-derived tumor xenograft (PDTX)>, Formula: C20H21CaN7O7, the main research area is medication gastrointestinal carcinoma human tumor xenograft clin study; Advanced gastrointestinal carcinomas; Clinical study; Patient-derived tumor xenograft; Personalized medication.

Establish patient-derived tumor xenograft (PDTX) from advanced GICs and assess the clin. value and applicability of PDTX for the treatment of advanced gastrointestinal cancers. Patients with advanced GICs were enrolled in a registered multi-center clin. study (ChiCTR-OOC-17012731). The performance of PDTX was evaluated by analyzing factors that affect the engraftment rate, comparing the histol. consistency between primary tumors and tumorgrafts, examining the concordance between the drug effectiveness in PDTXs and clin. responses, and identifying genetic variants and other factors associated with prognosis. Thirty-three patients were enrolled in the study with the engraftment rate of 75.8% (25/33). The success of engraftment was independent of age, cancer types, pathol. stages of tumors, and particularly sampling methods. Tumorgrafts retained the same histopathol. characteristics as primary tumors. Forty-nine regimens involving 28 drugs were tested in seventeen tumorgrafts. The median time for drug testing was 134.5 days. Follow-up information was obtained about 10 regimens from 9 patients. The concordance of drug effectiveness between PDTXs and clin. responses was 100%. The tumor mutation burden (TMB) was correlated with the effectiveness of single drug regimens, while the outgrowth time of tumorgrafts was associated with the effectiveness of combined regimens. The engraftment rate in advanced GICs was higher than that of other cancers and meets the acceptable standard for applying personalized therapeutic strategies. Tumorgrafts from PDTX kept attributes of the primary tumor. Predictions from PDTX modeling closely agreed with clin. drug responses. PDTX may already be clin. applicable for personalized medication in advanced GICs.

Journal of Cancer Research and Clinical Oncology published new progress about Aging, animal. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Formula: C20H21CaN7O7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Divya, Indira S.; Amrutha, Surendran; SeethaLekshmi, Sunil; Varughese, Sunil published the artcile< Molecular salts of quinine: a crystal engineering route to enhance the aqueous solubility>, Category: alcohols-buliding-blocks, the main research area is quinine mol salt crystal engineering aqueous solubility.

The antimalarial drug quinine (QUN) has poor aqueous solubility and belongs to Biopharmaceutical Classification System (BCS) Class-II. We report 12 novel mol. salts of QUN with α,ω-aliphatic dicarboxylic acids and aromatic coformers. The high basicity of QUN and ΔpKa of ~5 make the complexes ionic, and most of them are hydrates. The solid forms showed enhanced aqueous solubility compared to the pristine QUN. The single-crystal and powder X-ray diffraction, thermal, and microscopy data provide structural, compositional, and stability profiles of the salts. The calculated Full Interaction Maps (FIMs) provide statistical insights into the salt formation and high probability of hydration in QUN. Though with prospective torsional freedom, QUN in most complexes adopts a unique conformation; this indicates that the structure class has a higher statistical probability and belongs to a relatively deep potential energy trough in the vast crystal landscape.

CrystEngComm published new progress about Aliphatic dicarboxylic acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abdelgawad, Ibrahim Y.; Grant, Marianne K. O.; Zordoky, Beshay N. published the artcile< Leveraging the cardio-protective and anticancer properties of resveratrol in cardio-oncology>, SDS of cas: 501-36-0 , the main research area is review cardioncol cardiprotection resveratrol anticancer; anthracycline; cancer; cardio-oncology; cardiotoxicity; cardiovascular; resveratrol.

A review. Cardio-oncol. is a clin./scientific discipline which aims to prevent and/or treat cardiovascular diseases in cancer patients. Although a large number of cancer treatments are known to cause cardiovascular toxicity, they are still widely used because they are highly effective. Unfortunately, therapeutic interventions to prevent and/or treat cancer treatment-induced cardiovascular toxicity have not been established yet. A major challenge for such interventions is to protect the cardiovascular system without compromising the therapeutic benefit of anticancer medications. Intriguingly, the polyphenolic natural compound resveratrol and its analogs have been shown in preclin. studies to protect against cancer treatment-induced cardiovascular toxicity. They have also been shown to possess significant anticancer properties on their own, and to enhance the anticancer effect of other cancer treatments. Thus, they hold significant promise to protect the cardiovascular system and fight the cancer at the same time. In this review, we will discuss the current knowledge regarding the cardio-protective and the anticancer properties of resveratrol and its analogs. Thereafter, we will discuss the challenges that face the clin. application of these agents. To conclude, we will highlight important gaps of knowledge and future research directions to accelerate the translation of these exciting preclin. findings to cancer patient care.

Nutrients published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, SDS of cas: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts