Month: October 2022

Kooti, M.; Nasiri, E. published the artcile< Synthesis of a novel magnetic nanocatalyst based on rhodium complex for transfer hydrogenation of ketones>, Electric Literature of 403-41-8, the main research area is aralkyl alc preparation green chem; ketone transfer hydrogenation rhodium nanocatalyst.

A magnetic heterogeneous nanocatalyst based on novel rhodium complex is designed. The transfer hydrogenation of ketones R1C(O)R2 [R1 = Ph, PhCH2, 4-BrC6H4, etc., R2 = Me; R1 = Ph, R2 = BrCH2; R1 = 4-MeOC6H4, R2 = NCSCH2; R1R2 = (CH2)5] with 2-propanol as hydrogen donor and the rhodium complex as nanocatalyst was achieved. High yields of alcs. R1CH(OH)R2 under mild conditions were obtained from easily available precursors.

Applied Organometallic Chemistry published new progress about Green chemistry. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lesniak, Robert K.; Nichols, R. Jeremy; Schonemann, Marcus; Zhao, Jing; Gajera, Chandresh R.; Lam, Grace; Nguyen, Khanh C.; Langston, J. William; Smith, Mark; Montine, Thomas J. published the artcile< Discovery of 1H-Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors>, Electric Literature of 660867-80-1, the main research area is pyrazole biaryl sulfonamides preparation G2019S LRRK2 kinase inhibitor.

G2019S (GS) is the most prevalent mutation in the leucine rich repeat protein kinase 2 gene (LRRK2), a genetic predisposition that is common for Parkinson’s disease, as well as for some forms of cancer, and is a shared risk allele for Crohn’s disease. GS-LRRK2 has a hyperactive kinase, and although numerous drug discovery programs have targeted LRRK2 kinase, few have reached clin. development. We report the discovery and preliminary development of an entirely novel structural class of potent and selective GS-LRRK2 kinase inhibitors: biaryl-1H-pyrazoles.

ACS Medicinal Chemistry Letters published new progress about Crohn disease. 660867-80-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C12H18BNO2, Electric Literature of 660867-80-1.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bae, Kideog; Zheng, Wei; Ma, Ying; Huang, Zhiwei published the artcile< Real-Time Monitoring of Pharmacokinetics of Mitochondria-Targeting Molecules in Live Cells with Bioorthogonal Hyperspectral Stimulated Raman Scattering Microscopy>, HPLC of Formula: 10602-04-7, the main research area is raman scattering microscopy mitochondria pharmacokinetics live cells.

The dynamics of mitochondria in live cells play a pivotal role in biol. events such as cell metabolism, early stage apoptosis, and cell differentiation. Triphenylphosphonium (TPP) is a commonly used mitochondria-targeting agent for mitochondrial studies. However, there has been a lack of understanding in intracellular behaviors of TPP in the course of targeting mitochondria due to the difficulty in tracking and quantifying small mols. in a biol. environment. Here, we report the utility of hyperspectral stimulated Raman scattering (SRS) microscopy associated with a Raman tag synthesized for real-time visualization and quantitation of TPP dynamics within live cells at the subcellular level. With the myriad of merits offered by a synthesized aryl-diyne-based Raman tag such as excellent photostability, negligible background interferences, and a linear dependence of the SRS signal on the TPP concentration, we successfully establish a quant. model to associate the mitochondrial membrane potential with the key pharmacokinetic parameters of TPP inside the live cells. The model reveals that reduction in the mitochondrial membrane potential leads to significant decreases in both the uptake rate and intracellular concentrations of TPP. Further, on the basis of the multiplexed SRS images concurrently highlighting the cellular proteins and lipids without further labeling, we find that the TPP uptake causes little cytotoxicity to the host cells. The bioorthogonal hyperspectral SRS microscopy imaging reveals that TPP can maintain stable affinity to mitochondria during the restructuring of mitochondrial networking, demonstrating its great potential for real-time monitoring of pharmacokinetics of small mols. associated with live biol. hosts, thereby promoting the development of mitochondria-targeting imaging probes and therapies in the near future.

Analytical Chemistry (Washington, DC, United States) published new progress about Bioorthogonal reaction (bioorthogonal hyperspectral SRS microscopy). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, HPLC of Formula: 10602-04-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Hai-Lou; Lian, Chen; Yang, Guo-Yu published the artcile< A {Ti6W4}-Cluster-Substituted Polyoxotungstate: Synthesis, Structure, and Catalytic Oxidation Properties>, Recommanded Product: 2-(Phenylthio)ethanol, the main research area is methylammonium titanium tungstoantimonate cluster preparation crystal mol structure catalyst; oxidation catalyst methylammonium titanium tungstoantimonate cluster preparation.

A novel Ti-W-oxo-cluster substituted tungstoantimonate (TA) [H2N(CH3)2]3Na4H9[{Ti6W4O18(OH)(H2O)3}(B-α-SbW9O33)3]•20H2O (1) has been made by hydrothermal reactions of trivacant [B-α-SbW9O33]9- units, Ti4+ cations and WO42- anions in the presence of [H2N(CH3)2]•Cl and structurally characterized. Intriguingly, the polyoxoanion of 1 is constructed from three [B-α-SbW9O33]9- units and a previously unobserved decanuclear heterometallic Ti-W-oxo-cluster [Ti6W4O18(OH)(H2O)3]11+ {Ti6W4} that is comprised of an octahedral [Ti6WO6(H2O)3]18+ cluster and an edge-sharing [W3O12(OH)]7- fragment via six W-O-Ti/W linkers. Furthermore, studies on the catalytic oxidation properties reveal that 1 possesses good catalytic activity toward the oxidation reactions of various sulfides and cyclooctene basing on the environmentally friendly oxidant H2O2.

Inorganic Chemistry published new progress about Crystal structure. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Recommanded Product: 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Scott, Danielle A.; Norris-Caneda, Kim; Spruill, Laura; Bruner, Evelyn; Kono, Yuko; Angel, Peggi M.; Mehta, Anand S.; Drake, Richard R. published the artcile< Specific N-linked glycosylation patterns in areas of necrosis in tumor tissues>, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is tumor tissue necrosis glycosylation; N-linked glycans; formalin-fixed tissues; glycosylation; hypoxia; mass spectrometry imaging; necrosis.

Tissue necrosis is a form of cell death common in advanced and aggressive solid tumors, and is associated with areas of intratumoral chronic ischemia. The histopathol. of necrotic regions appear as a scaffold of cellular membrane remnants, reflective of the hypoxia and cell degradation events associated with this cellular death pathway. Changes in the glycosylation of cell surface proteins is another common feature of cancer progression. Using a recently developed mass spectrometry imaging approach to evaluate N-linked glycan distributions in human formalin-fixed clin. cancer tissues, differences in the glycan structures of regions of tumor, stroma and necrosis were evaluated. While the structural glycan classes detected in the tumor and stromal regions are typically classified as high mannose or branched glycans, the glycans found in necrotic regions displayed limited branching, contained sialic acid modifications and lack fucose modifications. While this phenomenon was initially classified in breast cancer tissues, it has been also seen in cervical, thyroid and liver cancer samples. These changes in glycosylation within the necrotic regions could provide further mechanistic insight to necrotic changes in cancer tissue and provide new research directions for identifying prognostic markers of necrosis.

International Journal of Mass Spectrometry published new progress about Cell death. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Safety of (2S,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Marques, Joao Paulo Cordeiro; Rios, Italo Castro; Arruda, Tathilene Bezerra Mota Gomes; Rodrigues, Francisco Eduardo Arruda; Uchoa, Antonia Flavia Justino; Tavares de Luna, Francisco Murilo; Cavalcante, Celio Loureiro; Ricardo, Nagila Maria Pontes Silva published the artcile< Potential Bio-Based Lubricants Synthesized from Highly Unsaturated Soybean Fatty Acids: Physicochemical Properties and Thermal Degradation>, SDS of cas: 104-76-7, the main research area is lubricant soybean fatty acid.

The use of mineral lubricants and petroleum derivatives has become, along the years, harmful to the environment, so renewable raw materials have gained expressive notoriety. The innovation of this study is to understand how the highly unsaturated content from soybean oil influences the physicochem. properties and the thermal behavior of synthesized biolubricant base stocks. The process used was carried out in three steps: esterification with 2-ethylhexanol, epoxidation, and oxirane ring opening with 2-ethylhexanol. The modifications were monitored by 1H NMR, the main physicochem. properties were measured, and the thermogravimetric behaviors of products were evaluated. The synthesized samples had high viscosity indexes (VI > 120) and viscosities that fit in application grade ISO-32. The samples using highly unsaturated fatty acids had a better pour point (-12 °C). The raw material composition directly influenced the physicochem. properties but did not affect the thermogravimetric behavior.

Industrial & Engineering Chemistry Research published new progress about Epoxidation. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, SDS of cas: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kraudelt, H.; Schilde, U.; Uhlemann, E. published the artcile< Crystal structures of 1-methylamino-D-1-deoxyglucitol, C7H17NO5 and 1-methylamino-D-1-deoxyglucitol hydrochloride, C7H18ClNO5>, Recommanded Product: N-Methyl-D-glucamine Hydrochloride, the main research area is mol structure methylaminodeoxyglucitol hydrochloride.

The 1st title compound is orthorhombic, space group P212121, a 4.615(1), b 10.240(2), c 19.810(9) Å, Z = 4, R = 0.040, Rw = 0.094 for 1787 reflections. The 2nd title compound is monoclinic, space group P21, a 7.401(2), b 8.681(3), c 8.789(4) Å, β 105.30(2)°, Z = 2, R = 0.026, Rw = 0.072 for 1592 reflections. At. coordinates are given. The H bonding in both mols. is discussed and some values given.

Zeitschrift fuer Kristallographie – New Crystal Structures published new progress about Crystal structure. 35564-86-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H18ClNO5, Recommanded Product: N-Methyl-D-glucamine Hydrochloride.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bampidis, Vasileios; Bastos, Maria de Lourdes; Christensen, Henrik; Dusemund, Birgit; Kouba, Maryline; Kos Durjava, Mojca; Lopez-Alonso, Marta; Lopez Puente, Secundino; Marcon, Francesca; Mayo, Baltasar; Pechova, Alena; Petkova, Mariana; Ramos, Fernando; Sanz, Yolanda; Villa, Roberto Edoardo; Woutersen, Ruud; Tarres-Call, Jordi; Azimonti, Giovanna; EFSA Panel on Additives and Products or Substances used in Animal Feed published the artcile< Safety for the environment of vitamin D3 for salmonids>, Related Products of 434-16-2, the main research area is environmental safety vitamin D3 salmonid; cholecalciferol; fish; nutritional additive; safety; vitamin D3; vitamins and provitamins.

The Panel on Additives and Products or Substances used in Animal Feed (FEEDAP Panel) of EFSA assessed the safety for the target species and the consumer of the use of a maximum total level of 1.5 mg vitamin D3/kg feed in fish nutrition (2017). The assessment was based on data that had been provided by the Norwegian Food Safety Authority (NFSA). Since the data set provided by the NFSA did not include any new information concerning the safety for the user and the environment, the 2017 opinion did not address the potential effects of the proposed increase in the maximum authorised levels of vitamin D3 on the safety for the user and the environment. The NFSA has submitted addnl. data and the European Commission has requested EFSA to deliver a new opinion on the safety for the environment of vitamin D3 as a nutritional additive for salmonids. Planktonic microalgae, inhabiting the sea, are a large group of photosynthetic organisms that contain both vitamin D3 and provitamin D3. Marine phytoplankton is distributed throughout the sea serving as the basis for all marine food webs. Therefore, since it is produced by phytoplankton, vitamin D3 may also be considered as being ubiquitous in the aquatic environment. Considering the different sources of vitamin D3 already present in the marine environment, the FEEDAP Panel considers that an increase in concentration of vitamin D3 when used as a feed additive in compound feed for salmonids up to a maximum of 1.5 mg/kg is not expected to pose a risk for the environment.

EFSA Journal published new progress about Aquatic environment. 434-16-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C27H44O, Related Products of 434-16-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Tingna; Zeng, Hairong; Zeng, Yijia; Zhang, Xiaorui; Ren, Yuanyuan; Gao, Yongxiang; Huang, Qinwan; Tan, Jin published the artcile< Characterization of the bioactive compounds with efficacy against gout in Guizhi Shaoyao Zhimu Decoction by UHPLC-Q-Orbitrap HRMS combined with network pharmacological analysis>, Application In Synthesis of 87-73-0, the main research area is Guizhi Shaoyao Zhimu decoction antiarthritic agent gouty arthritis.

The current study aimed to explore the mechanism of Guizhi Shaoyao Zhimu Decoction in the treatment of gouty arthritis based on the combination of Vanquish Ultra High Performance Liquid Chromatog. Q Exactive IV Pole-electrostatic field orbital trap high resolution mass spectrometer (UHPLC-Q-Orbitrap HRMS) and network pharmacol. Firstly, UHPLC-Q-Orbitrap HRMS was established and applied to separation and identification of the chem. components of GSZD. Then, using network pharmacol. anal. to obtain the potential active components and candidate targets underlying the effect of GSZD on gouty arthritis (GA). Through targeted and untargeted anal., a total of 79 components, including 3 chromones, 26 flavonoids, 10 alkaloids, 10 phenolic acids, 7 nucleosides and nucleobases, and 23 other components, were characterized from GSZD. 11 compounds were considered to potentially key active compounds against GA which may be via interacting with multiple inflammatory factors and multiple inflammatory pathways.

Arabian Journal of Chemistry published new progress about Activator protein 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Application In Synthesis of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saikia, Gangutri; Ahmed, Kabirun; Rajkhowa, Chandrasee; Sharma, Mitu; Talukdar, Hiya; Islam, Nashreen S. published the artcile< Polymer immobilized tantalum(V)-amino acid complexes as selective and recyclable heterogeneous catalysts for oxidation of olefins and sulfides with aqueous H2O2>, Category: alcohols-buliding-blocks, the main research area is olefin tantalum amino acid heterogeneous catalyst chemoselective oxidation green; epoxide preparation; sulfide tantalum amino acid heterogeneous catalyst chemoselective oxidation green; sulfoxide preparation.

Polymer supported heterogeneous peroxotantalum(V) catalysts were prepared by anchoring Ta(V)-diperoxo species to chloromethylated poly(styrene-divinylbenzene) resin functionalized with amino acids asparagine (L-Asn) and arginine (L-Arg). The structurally well-defined catalysts, [Ta(O2)2(L)2]–MR, [L = asparagine (catalyst 1) or arginine (catalyst 2) and MR = Merrifield resin], were comprehensively characterized by elemental anal. (CHN, ICP-OES, energy dispersive X-ray spectroscopy), spectral studies (FT-IR, Raman, 13C NMR, diffuse reflectance UV-vis and XPS), SEM, XRD, Brunauer-Emmett-Teller (BET) and thermogravimetric anal. (TGA). The supported peroxotantalum (pTa) compounds displayed excellent catalytic performance in epoxidation of alkenes with 30% H2O2, under solvent free reaction conditions. Styrene was epoxidized with >99% selectivity with the highest TOF of 1040 h-1 obtained within 30 min reaction time, whereas the TOF for norbornene epoxidation was 2000 h-1 within 1 h with >95% epoxide selectivity. Furthermore, the immobilized catalysts facilitated chemoselective oxidation of a broad range of organic sulfides to the desired sulfoxides with H2O2 in methanol, under mild reaction conditions. The oxidations proceeded with a high H2O2 efficiency percentage and are amenable to ready scalability. The heterogeneous catalysts could be easily recovered and reused for several consecutive catalytic cycles with undiminished activity/selectivity profiles in all cases. The developed catalytic strategies are operationally simple and, being free from halogenated solvent or any other toxic auxiliaries, environmentally clean.

New Journal of Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts