Month: October 2022

In 2014,Gentles, Robert G.; Ding, Min; Bender, John A.; Bergstrom, Carl P.; Grant-Young, Katharine; Hewawasam, Piyasena; Hudyma, Thomas; Martin, Scott; Nickel, Andrew; Regueiro-Ren, Alicia; Tu, Yong; Yang, Zhong; Yeung, Kap-Sun; Zheng, Xiaofan; Beno, Brett R.; Camac, Daniel M.; Chang, Chong-Hwan; Gao, Mian; Morin, Paul E.; Sheriff, Steven; Tredup, Jeff; Wan, John; Witmer, Mark R.; Xie, Dianlin; Hanumegowda, Umesh; Knipe, Jay; Mosure, Kathy; Santone, Kenneth S.; Parker, Dawn D.; Zhuo, Xiaoliang; Lemm, Julie; Liu, Mengping; Pelosi, Lenore; Rigat, Karen; Voss, Stacey; Wang, Yi; Wang, Ying-Kai; Colonno, Richard C.; Gao, Min; Roberts, Susan B.; Gao, Qi; Ng, Alicia; Meanwell, Nicholas A.; Kadow, John F. published 《Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase》.Journal of Medicinal Chemistry published the findings.Related Products of 18621-18-6 The information in the text is summarized as follows:

Described herein are structure-activity relationship studies that resulted in the optimization of the activity of members of a class of cyclopropyl-fused indolobenzazepine HCV NS5B polymerase inhibitors. Subsequent iterations of analog design and syntheses successfully addressed off-target activities, most notably human pregnane X receptor (hPXR) transactivation, and led to significant improvements in the physicochem. properties of lead compounds Those analogs exhibiting improved solubility and membrane permeability were shown to have notably enhanced pharmacokinetic profiles. Addnl., a series of alkyl bridged piperazine carboxamides was identified as being of particular interest, and from which the compound BMS-791325 (I) was found to have distinguishing antiviral, safety, and pharmacokinetic properties that resulted in its selection for clin. evaluation. The results came from multiple reactions, including the reaction of Azetidin-3-ol hydrochloride(cas: 18621-18-6Related Products of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Related Products of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2017,Liu, Xun; Deaton, T. Maxwell; Haeffner, Fredrik; Morken, James P. published 《A Boron Alkylidene-Alkene Cycloaddition Reaction: Application to the Synthesis of Aphanamal》.Angewandte Chemie, International Edition published the findings.Application In Synthesis of Bis[(pinacolato)boryl]methane The information in the text is summarized as follows:

The authors describe an unusual net [2+2] cycloaddition reaction between B alkylidenes and unactivated alkenes. This reaction provides a new method for the construction of carbocyclic ring systems bearing versatile organoboronic esters. Aside from surveying the scope of this reaction, the authors provide details about the mechanistic underpinnings of this process, and examine its application to the synthesis of the natural product aphanamal. In the experiment, the researchers used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Application In Synthesis of Bis[(pinacolato)boryl]methane)

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. This stems from their ease of preparation combined with their ability to undergo a broad range of chemical transformations.Application In Synthesis of Bis[(pinacolato)boryl]methane

Referemce:
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In 2017,Wang, Lu; Zhang, Tao; Sun, Wei; He, Zeyu; Xia, Chungu; Lan, Yu; Liu, Chao published 《O Functionalization of α-Oxyboronates: A Deoxygenative gem-Diborylation and gem-Silylborylation of Aldehydes and Ketones》.Journal of the American Chemical Society published the findings.COA of Formula: C13H26B2O4 The information in the text is summarized as follows:

A deoxygenative gem-diborylation and gem-silylborylation of aldehydes and ketones is described. The key for the success of this transformation is the base-promoted C-O bond borylation or silylation of the generated α-oxyboronates. Exptl. and theor. studies exhibit that the C-O bond functionalization proceeds via an intramol. five-membered transition-state, boryl migration followed by a 1,2-metalate rearrangement with OBpin as a leaving group. The transformation occurs with an inversion on the C center. Direct conversion of aldehydes and ketones to gem-diboron compounds was achieved by combining Cu catalysis with this base-promoted C-OBpin borylation. Various aldehydes and ketones were deoxygenatively gem-diborylated. Gem-Silylborylation of aldehydes and ketones were achieved by a stepwise operation, in which B2pin2 initially react with those carbonyls followed by a silylation with Bpin-SiMe2Ph. In addition to this study using Bis[(pinacolato)boryl]methane, there are many other studies that have used Bis[(pinacolato)boryl]methane(cas: 78782-17-9COA of Formula: C13H26B2O4) was used in this study.

Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.COA of Formula: C13H26B2O4

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Alcohol – Wikipedia,
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In 2018,Yang, Guo-Hui; Li, Yao; Li, Xin published 《Chirality Sensing of Molecules with Diverse Functional Groups by Using N-tert-Butyl Sulfinyl Squaramide》.Asian Journal of Organic Chemistry published the findings.Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

The readily available bifunctional 3,5-[di(trifluoromethyl)]phenyl-substituted N-tert-Bu sulfinyl squaramide was used as a unique chiral solvating agent. The strong hydrogen-bonding donor ability of this chiral compound led to its effective use in the chiral recognition of multiple guest mols. In the experiment, the researchers used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Reference of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Balaji, B. S.; Dalal, Neha published 《An expedient, chemoselective N-chloroacetylation of amino alcohols under metal-free bio-compatible conditions》.Green Chemistry Letters and Reviews published the findings.Related Products of 27489-62-9 The information in the text is summarized as follows:

For the first time, the authors report an efficient, highly chemoselective N-chloroacetylation of amino compounds (amino alcs., amino acids) by chloroacetyl chloride, without compromising its high reactivity, to give chloroacetamides in phosphate buffer within 20 min. A systematic study of the effects of buffers, metal salts and HCl scavengers to optimize the reaction conditions is described. Intermol. competitive reactions were carried out and showed that anilines and aliphatic amines could be selectively N-chloroacylated in the presence of alcs. and phenols. The acylated products were obtained in high yields and could be easily isolated without chromatog. separation This reaction represents the first example of a metal-free bio-compatible synthesis under neutral conditions. This method is eco-friendly, easily scalable and robust. Intramol. competitive reactions of aminoalcs. were further studied and gave various N-chloroacetamides in very good yields. Finally, this protocol was conveniently extended to the synthesis of ceramides. In the part of experimental materials, we found many familiar compounds, such as trans-4-Aminocyclohexanol(cas: 27489-62-9Related Products of 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Related Products of 27489-62-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2018,Sandfort, Frederik; Strieth-Kalthoff, Felix; Klauck, Felix J. R.; James, Michael J.; Glorius, Frank published 《Deaminative Borylation of Aliphatic Amines Enabled by Visible Light Excitation of an Electron Donor-Acceptor Complex》.Chemistry – A European Journal published the findings.Safety of trans-4-Aminocyclohexanol The information in the text is summarized as follows:

A deaminative strategy for the borylation of aliphatic primary amines is described. Alkyl radicals derived from the single-electron reduction of redox-active pyridinium salts, which can be isolated or generated in situ, were borylated in a visible light-mediated reaction with bis(catecholato)diboron. No catalyst or further additives were required. The key electron donor-acceptor complex was characterized in detail by both exptl. and computational investigations. The synthetic potential of this mild protocol was demonstrated through the late-stage functionalization of natural products and drug mols. In the experimental materials used by the author, we found trans-4-Aminocyclohexanol(cas: 27489-62-9Safety of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Safety of trans-4-Aminocyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of Medicinal Chemistry included an article by Wild, Christopher T.; Miszkiel, Joanna M.; Wold, Eric A.; Soto, Claudia A.; Ding, Chunyong; Hartley, Rachel M.; White, Mark A.; Anastasio, Noelle C.; Cunningham, Kathryn A.; Zhou, Jia. Synthetic Route of C3H9NO2. The article was titled 《Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor》. The information in the text is summarized as follows:

Cis-alkylpiperidinecarboxamides such as I were prepared as pos. allosteric modulators of the 5-HT2c receptor for potential use in the prevention of cocaine addiction relapse. I potentiated 5-HT-evoked intracellular calcium release in cells stably expressing the human 5-HT2c receptor but not cells expressing human 5-HT2a receptors. Mol. docking calculations of I at the 5-HT2c receptor identified a topog. distinct allosteric site. The pharmacokinetics of I upon i.v. administration, its toxicity, and its selectivity for the 5-HT2c receptor over a variety of other competing receptors was determined I modulated 5-HT2c receptor-mediated spontaneous ambulation, partially substituted for the training dose of the 5-HT2c receptor agonist WAY163909, synergized with a low dose of WAY163909 to substitute fully for the stimulus effects of WAY163909, and attenuated relapse vulnerability as assessed in a rodent self-administration model, indicating its therapeutic promise for cocaine use disorder. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Synthetic Route of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Synthetic Route of C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of Physical Chemistry A included an article by Batista, Patrick R.; Karas, Lucas J.; Viesser, Renan V.; de Oliveira, Cynthia C.; Goncalves, Marcos B.; Tormena, Claudio F.; Rittner, Roberto; Ducati, Lucas C.; de Oliveira, Paulo R.. Recommanded Product: 3-Aminopropan-1-ol. The article was titled 《Dealing with Hydrogen Bonding on the Conformational Preference of 1,3-Aminopropanols: Experimental and Molecular Dynamics Approaches》. The information in the text is summarized as follows:

This study expands the knowledge on the conformational preference of 1,3-amino alcs. in the gas phase and in solution By employing Fourier transform IR spectroscopy, NMR spectroscopy, d. functional theory (DFT) calculations, quantum theory of atoms in mols. (QTAIM), natural bond orbital (NBO) anal., and mol. dynamics (MD), the compounds 3-aminopropan-1-ol (1), 3-methylaminopropan-1-ol (2), and 3-dimethylaminopropan-1-ol (3) are evaluated. The results show that the most stable conformation of each compound in the gas phase and in nonpolar solvents exhibited an O-H···N intramol. hydrogen bond (IHB). Based on the exptl. and theor. OH-stretching frequencies, the IHB becomes stronger from 1 to 3. In addition, from the exptl. NMR J-couplings, the IHB conformers are predominant in nonbasic solvents, representing 70-80% of the conformational equilibrium, while in basic solvents, such conformers only represent 10%. DFT calculations and QTAIM anal. in the gas phase support the occurrence of IHBs in these compounds The MD simulation indicates that the non-hydrogen-bonded conformers are the lowest energy conformations in the solution because of mol. interactions with the solvent, while they are absent in the implicit solvation model based on d. NBO anal. suggests that Me groups attached on the nitrogen atom affect the charge transfer energy involved in the IHB. This effect occurs mostly because of a decrease in the s-character of the LPN orbital along with weakening of the charge transfer from LPN to σ*OH, which is caused by an increase in the C-C-N bond angle. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Recommanded Product: 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Journal of the Indian Chemical Society included an article by Kavitha, G.; Vedhi, C.. HPLC of Formula: 1195-59-1. The article was titled 《Synthesis and characterization of benzoin α-oxime and 2,6-pyridine dimethanol and its application of anti-corrosion behaviour》. The information in the text is summarized as follows:

Synthesis of benzoin α-oxime and 2,6-pyridine dimethanol through eco-friendly method. These synthesized compounds are characterized by UV-Visible, FTIR and NMR spectral techniques. Anti-corrosion behavior of benzoin α-oxime and 2,6-pyridine dimethanol both the compounds studied with 2 N sulfuric acid on mild steel. The anti-corrosion behavior of the synthesized compounds was studied by subjecting to weight loss measurements, polarization studies and electrochem. impedance spectra (EIS) for the assessment of its performance. The studies were made with 2 N sulfuric acid as the corroding medium, but with the inhibitors concentration in the range of 50-350 ppm. The results revealed that the inhibitor studied perform better in the medium and function by the mechanism of adsorption on the metal surface. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1HPLC of Formula: 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.HPLC of Formula: 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,European Journal of Medicinal Chemistry included an article by Feng, Yue; Xie, Xiao-Yang; Yang, Yi-Qiu; Sun, Yu-Tong; Ma, Wen-Hui; Zhou, Peng-Jun; Li, Zi-Yao; Liu, Hui-Qiang; Wang, Yi-Fei; Huang, Yun-Sheng. Electric Literature of C6H13NO. The article was titled 《Synthesis and evaluation of pyrimidoindole analogs in umbilical cord blood ex-vivo expansion》. The information in the text is summarized as follows:

The synthesis of pyrimidoindole analogs I [R = dimethylamino, 3-chloro-4-fluoroanilino, 3,4-dimethoxyphenthylamino, etc.] and II [R1 = anilino, morpholino, indole-3-ethylamino, etc.] and identified 6 compounds to be potent in promoting HSC ex vivo expansion. In particular, analog I [R = 2-(6,7-dimethoxy-1,2,3,4-trtrahydroisoquinolino)ethylamino (III)] was found to be the most effective in stimulating ex-vivo expansion of UCB CD34+ cells and CD34+CD38- cells. Initial data indicated that compound III promoted the absolute number of long term HSCs and inhibited their differentiation. UCB HSCs expanded with III retained adequate multi-lineage differentiation capacity. In addition, compound III was not cytotoxic at its test concentrations, suggested that it merits further investigation for potential clin. applications. In the experiment, the researchers used many compounds, for example, trans-4-Aminocyclohexanol(cas: 27489-62-9Electric Literature of C6H13NO)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Electric Literature of C6H13NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts