Month: October 2022

《A flexible paper-based chemosensor for colorimetric and ratiometric fluorescence detection of toxic oxalyl chloride》 was written by Chen, Tianhong; Jiang, Lirong; Yuan, Hou-Qun; Zhang, Yue; Su, Dongdong; Bao, Guang-Ming. Category: alcohols-buliding-blocks And the article was included in Sensors and Actuators, B: Chemical in 2020. The article conveys some information:

The screening of highly toxic chem. vapor is critical for environmental monitoring and human health maintenance. Herein, we reported a chemosensor (AC-HPD) for rapid and specific detection of highly toxic oxalyl chloride vapor, which adopted anthracene carboxyimide as a fluorophore and 3-aminopropanol as the reaction site. Upon coupling of oxalyl chloride with NH and OH groups, AC-HPD exhibited remarkable colorimetric and ratiometric fluorescence dual-mode responses towards oxalyl chloride via the intramol. charge transfer effect. AC-HPD could determine oxalyl chloride with features of rapid response, excellent specificity, low detection limit (95 nM), as well as obvious color and fluorescence change. Furthermore, AC-HPD-embedded test strip was successfully fabricated and used as a flexible sensing device for rapid, sensitive and visible monitoring oxalyl chloride vapor. After reading the article, we found that the author used 3-Aminopropan-1-ol(cas: 156-87-6Category: alcohols-buliding-blocks)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lenormand, Anthony; Reyes Mendez, Lucia; Coulomb, Julien published their research in Chemistry – A European Journal in 2021. The article was titled 《Relay-Heck Cross-Coupling Between Alkenyl Halides and Unsaturated Alcohols in the Synthesis of Open-Chain Analogues of Musk Odorant Vulcanolide》.Related Products of 821-41-0 The article contains the following contents:

Unactivated alkenyl iodides and bromides underwent an unprecedented palladium-catalyzed relay-Heck cross-coupling with a whole range of alkenols of different chain lengths linking the alkene and the alc., affording unsaturated aldehydes and ketones in moderate to good yields. In contrast, alkenyl triflates were not suitable partners for this reaction. This method allowed the preparation of open-chain analogs of the musk odorant Vulcanolide, several of which retained key olfactory properties of the parent mol. The experimental process involved the reaction of 5-Hexen-1-ol(cas: 821-41-0Related Products of 821-41-0)

5-Hexen-1-ol(cas: 821-41-0) is a volatile organic compound. Further, it is used to prepare 6-bromo-hex-1-ene by reaction with phosphorus tribromide.Related Products of 821-41-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chang, Zhiqian; Zhu, Huilong; Wu, Changhui; Xing, Junhao; Dou, Xiaowei published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《A rhodium-catalyzed conjugate addition/cyclization cascade for the asymmetric synthesis of 2-amino-4H-chromenes》.Electric Literature of C6H7BO3 The article contains the following contents:

The enantioselective synthesis of 2-amino-4H-chromenes via the cascade rhodium-catalyzed conjugate addition/hetero Thorpe-Ziegler reaction is reported. Moderate to good yields (up to 98%) and high enantioselectivities (up to 92% ee) were obtained with a chiral diene-coordinated rhodium complex as the catalyst. This protocol remedies the methodol. deficiency in the asym. synthesis of 4-aryl 2-amino-4H-chromenes. In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0Electric Literature of C6H7BO3)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Electric Literature of C6H7BO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sato, Masanori; Kondo, Takekazu; Kohno, Yasushi; Seto, Shigeki published their research in Bioorganic & Medicinal Chemistry in 2021. The article was titled 《Discovery of benzo[f]pyrido[4,3-b][1,4]oxazepin-10-one derivatives as orally available bromodomain and extra-terminal domain (BET) inhibitors with efficacy in an in vivo psoriatic animal model》.Electric Literature of C6H13NO The article contains the following contents:

Several compounds I (R1 = H, F; R2 = H, F, Cl, OMe; X = O, S) starting from previously reported pyrido-benzodiazepinone derivative II were designed and synthesized to enhance BRD4 inhibitory activity while avoiding hERG inhibition. Mol. docking studies and structure-activity relationship studies led to the identification of 9-fluorobenzo[f]pyrido[4,3-b][1,4]oxazepin-10-one derivative I (X = O; R1 = F; R2 = H), which exhibited potent BRD4 inhibitory activity with excellent potency in imiquimod-induced psoriasis model mice.trans-4-Aminocyclohexanol(cas: 27489-62-9Electric Literature of C6H13NO) was used in this study.

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Electric Literature of C6H13NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yuechun; Wang, Yuqin; Shen, Jiabing; Chen, Xiang published their research in Latin American Journal of Pharmacy in 2021. The article was titled 《Protective effect of azaindole on cerebral hemorrhage in rat model through down-regulation of TGF-β mediated ERK pathway》.Product Details of 7748-36-9 The article contains the following contents:

The present study investigated azaindole as therapeutic agent for treatment of cerebral hemorrhage in the rat model. Azaindole treatment in dose dependent manner enhanced viability of neurons and decreased escape latency in cerebral hemorrhage rats compared to the untreated group. Moreover, infarct volume showed a significant (p < 0.05) decrease in cerebral hemorrhage rats on treatment with azaindole in 1.0 to 1.75 mg/kg dosage range. Azaindole treatment of cerebral hemorrhage rats significantly (p < 0.05) decreased CWC, improved BBB and increased proportion of Iba1 and MPO +ive cells in neuronal cultures. Treatment with azaindole prevented induction of neuronal apoptosis, promoted Bcl2 and Bclxl proteins and suppressed Bad and Bax protein protein expression. Addnl., Azaindole elevated TGF-β and ERK protein expression in cerebral hemorrhage rats. Thus, azaindole promoted viability of neurons and decreased infarct volume in cerebral hemorrhage rats through TGF-β and ERK/p-ERK pathway up-regulation. Therefore, azaindole inhibits neuronal damage and may be developed for ischemic reperfusion mediated cerebral hemorrhage treatment. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Seierstad, Mark; Tichenor, Mark S.; DesJarlais, Renee L.; Na, Jim; Bacani, Genesis M.; Chung, De Michael; Mercado-Marin, Eduardo V.; Steffens, Helena C.; Mirzadegan, Taraneh published their research in ACS Medicinal Chemistry Letters in 2021. The article was titled 《Novel Reagent Space: Identifying Unorderable but Readily Synthesizable Building Blocks》.Application of 18621-18-6 The article contains the following contents:

Drug discovery building blocks available com. or within an internal inventory cover a diverse range of chem. space and yet describe only a tiny fraction of all chem. feasible reagents. Vendors will eagerly provide tools to search the former; there is no straightforward method of mining the latter. We describe a procedure and use case in assembling chem. structures not available for purchase but that could likely be synthesized in one robust chem. transformation starting from readily available building blocks. Accessing this vast virtual chem. space dramatically increases our curated collection of reagents available for medicinal chem. exploration and novel hit generation, almost tripling the number of those with 10 or fewer atoms. In addition to this study using Azetidin-3-ol hydrochloride, there are many other studies that have used Azetidin-3-ol hydrochloride(cas: 18621-18-6Application of 18621-18-6) was used in this study.

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Gang; Kim, Hyejin; Wang, Pingyuan; Fricke, Doerte R.; Chen, Haiying; Wang, Tianzhi; Shen, Qiang; Zhou, Jia published an article in 2021. The article was titled 《Further lead optimization on Bax activators: Design, synthesis and pharmacological evaluation of 2-fluoro-fluorene derivatives for the treatment of breast cancer》, and you may find the article in European Journal of Medicinal Chemistry.HPLC of Formula: 100-55-0 The information in the text is summarized as follows:

Fluorofluorene I exhibited a good balance between antitumor activity and toxicity, displaying submicromolar activities against a variety of cancer cell lines with 5.8-10.7-fold selectivity of decreased activity to MCF-10A human mammary epithelial cell line. Compound I dose-dependently blocked colony formation of breast cancer cells and prevented the migration and invasion of MDA-MB-231 cells. Mechanism of action studies indicate that I activated Bax, rendering its insertion into mitochondrial membrane, thereby leading to cytochrome c release from the mitochondria into the cytoplasm, subsequently inducing release of apoptotic biomarkers. Further in vivo efficacy studies of I in human breast cancer xenografts arisen from MDA-MB-231 cells demonstrated that this drug candidate significantly suppressed tumor growth, indicating the therapeutic promise of this class of compounds for the treatment of breast cancer as well as the potential for developing F-radiolabeled imaging ligands as anticancer chem. probes. After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0HPLC of Formula: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 100-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qin, Nianqiao; Pan, An; Yuan, Jun; Ke, Fei; Wu, Xiaoyan; Zhu, Jing; Liu, Jianqiang; Zhu, Junfa published an article in 2021. The article was titled 《One-Step Construction of a Hollow Au@Bimetal-Organic Framework Core-Shell Catalytic Nanoreactor for Selective Alcohol Oxidation Reaction》, and you may find the article in ACS Applied Materials & Interfaces.Computed Properties of C7H9NO2 The information in the text is summarized as follows:

Hollow core-shell catalytic nanoreactors have received tremendous attention due to their high mass transfer in catalysis applications. Herein, we present a novel type of well-arranged, hollow core-shell nanoreactors featured with a bimetallic porous Zn/Ni-MOF-2 shell and a tiny Au nanoparticle core. The well-designed hollow Au@Zn/Ni-MOF-2 nanoreactors were constructed through the strategy of a facile one step from a rare crystal-structure transformation without any addnl. template. These nanoreactors exhibit outstanding multifunctional catalysis for a broad range of alc. oxidation under the green oxidant environment. Moreover, such hollow nanoreactors show excellent recyclability toward the selective alc. oxidation These findings might provide a promising platform for a general construct of various metal-organic framework-based hollow core-shell nanostructures and further highly augmented catalytic applications. In the experimental materials used by the author, we found 2,6-Pyridinedimethanol(cas: 1195-59-1Computed Properties of C7H9NO2)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C7H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Picken, Stephen J.; Filonenko, Georgy A. published an article in 2021. The article was titled 《Environmentally Sensitive Luminescence Reveals Spatial Confinement, Dynamics, and Their Molecular Weight Dependence in a Polymer Glass》, and you may find the article in ACS Applied Polymer Materials.Name: 2,6-Pyridinedimethanol The information in the text is summarized as follows:

Polymer glasses have an irregular structure. Among the causes for such complexity are the chem. distinct chain end groups that are the most abundant irregularities in any linear polymer. In this work, we demonstrate that chain end induced defects allow polymer glasses to create confined environments capable of hosting small emissive mols. Using environmentally sensitive luminescent complexes, we show that the size of these confinements depends on mol. weight and can dramatically affect the photoluminescence of free or covalently bound emissive complexes. We confirm the impact of chain end confinement on the bulk glass transition in poly(Me acrylate) (pMA) and show that commonly observed Tg changes induced by the chain ends should have a structural origin. Finally, we demonstrate that the size and placement of luminescent mol. probes in pMA can dramatically affect the probe luminescence and its temperature dependence, suggesting that polymer glass is a highly irregular and complex environment, marking its difference with conventional small mol. solvents. Considering the ubiquity of luminescent glassy materials, our work lays down a blueprint for designing them with structural considerations in mind, ones where packing d. and chain end size are key factors. After reading the article, we found that the author used 2,6-Pyridinedimethanol(cas: 1195-59-1Name: 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Name: 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hosseini, Seyed Mohammad; Karimi, Meghdad; Safarifard, Vahid published an article in 2021. The article was titled 《Metal-organic framework/carbon nitride nanosheets composites (TMU-49/CNNSs): efficient photocatalyst for aerobic oxidation of alcohols under visible light》, and you may find the article in New Journal of Chemistry.Formula: C7H7BrO The information in the text is summarized as follows:

Oxidation reactions are considered as a challenging issue at the industrial scale. As several traditional methods are not biocompatible and safe, there is a need to develop sustainable photocatalytic approaches that employ mol. oxygen as the terminal oxidant. Herein, a cobalt-based metal-organic framework (MOF) was hybridized with graphitic carbon nitride nanosheets (CNNSs), namely TMU-49/CNNSs, using a facile in situ ultrasound-assisted synthesis, for the catalytic photo-oxidation of benzyl alc. under visible light irradiation The oxidation was carried out with variation of four parameters: solvent, catalyst amount, time and light source. Characterization of as-prepared samples was performed by Fourier-transform IR spectroscopy, thermogravimetric anal., X-ray powder diffraction, N2 adsorption-desorption, SEM, and UV-visible diffuse reflection spectra. The TMU-49/CNNSs composite exhibited remarkable photocatalytic activity under visible light irradiation; the oxidation yield reached almost 80% for benzyl alc. after 3 h reaction. The superior photocatalytic activity of the MOF/CNNSs composite is attributed to enhanced separation of the photogenerated electron-hole pairs and increased visible-light absorption. After reading the article, we found that the author used (4-Bromophenyl)methanol(cas: 873-75-6Formula: C7H7BrO)

(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Formula: C7H7BrO It undergoes oxidation reaction in the presence of polyvinylpolypyrrolidone-supported hydrogen peroxide, silica sulfuric acid and ammonium bromide to yield 4-bromobenzaldehyde.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts