Month: October 2022

Jabir, Majid S.; Taha, Ali A.; Sahib, Usama I.; Taqi, Zainab J.; Al-Shammari, Ahmed M.; Salman, Alya S. published the artcile< Novel of nano delivery system for Linalool loaded on gold nanoparticles conjugated with CALNN peptide for application in drug uptake and induction of cell death on breast cancer cell line>, Name: 3,7-Dimethylocta-1,6-dien-3-ol, the main research area is breast cancer linalool gold nanoparticle CALNN peptide anticancer; Antioxidant activity; CALNN; Cellular uptake; Cytotoxicity; FTIC; Gold nanoparticles; Linalool; MCF-7.

Linalool is a monoterpene alc. which occurs naturally in several aromatic plants. The aims of this study are to load Linalool on gold nanoparticles, conjugate the complex with CALNN peptide, and investigate them for in-vitro anticancer activities against breast cancer (MCF-7) cell line. Linalool was obtained with 98% purity while gold nanoparticles and CALNN peptide were chem. synthesized. The formation of LIN-GNPs and LIN-GNPs-CALNN was observed through a color change. These compounds were confirmed and characterized using SEM, DLS, AFM, UV-VIS spectrophotometer, XRD, and FTIR. The free radical scavenging potential of each compound was confirmed based on its stable antioxidant effects using different parameters. Blood compatibility on red blood cells was confirmed by hemolytic and in vitro cytotoxicity assays. The in-vitro anticancer activity of each compound towardMCF-7 cell line was investigated using various parameters. From the results, Linalool, GNPs, LIN-GNPs, and LIN-GNPs-CALNN were found to exert cell growth arrest against MCF-7 cell line. The anti-proliferative effect of these compounds was due to cell death and induction of apoptosis confirmed using acridine orange-Ethidium bromide dual staining, DAPI staining, and electrophoresis anal. of DNA fragmentation. High fluorescent signals specific for the cellular uptake of LIN-GNPs and LIN-GNPs-CALNN into the cytoplasm of the cell line were confirmed. To study the toxicity of LIN-GNPs-CALNN in animal models, the hematol., histopathol., and body weight changes were estimated after 4 wk of i.p. injection of the compounds into the animal models. Our results demonstrate that Linalool, GNPs, Linalool-GNPs, and Linalool-GNPs-CALNN peptide had no side effects and could be clin. used for future therapeutic purposes.

Materials Science & Engineering, C: Materials for Biological Applications published new progress about Antioxidants. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Name: 3,7-Dimethylocta-1,6-dien-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Razavi, Seyed Mohammad; Haghtalab, Ali; Khanchi, Ali Reza published the artcile< Optimization of vanadium(V) extraction by 2-ethyl-1-hexanol and the study of extraction reaction mechanism>, Electric Literature of 104-76-7, the main research area is vanadium extraction reaction mechanism thermodn property.

The aims of the present work are to investigate the mechanism and thermodn. of pentavalent vanadium (V(V)) extraction by 2-ethyl-1-hexanol and to optimize the extraction process. The stoichiometry of V(V) extraction reaction and the extraction equilibrium constants at different temperatures were determined using the slope anal. method applied to the exptl. data. It was shown that the extracted V(V) was in the form of HVO3(ROH) in the organic phase. The standard enthalpy and the standard entropy of extraction reaction were calculated as 39.56 kJ/mol and 54.38 J/(mol.K), resp. A statistical exptl. design method, including Plackett-Burman design (PBD) followed by a central composite design (CCD), was employed to obtain the regression models for the prediction of extraction percentages and to optimize the recovery of V(V) from a synthetic leach solution containing Fe(III), U(VI), Si(IV), and Al(III). The accuracy of the predictive models was proven by the anal. of variance (ANOVA). The optimum condition for selective separation of V(V) was: initial pH of 1.9, extractant concentration of 70%volume/volume, and T=59.3°C. Under the optimum condition, the extraction percentages for V(V), Fe(III), U(VI), Si(IV), and Al(III) were 91.3%, 1.7%, 6.3%, 10.6%, 2.7%, resp. Developed models were validated by solvent extraction experiments at optimum conditions.

Minerals Engineering published new progress about Enthalpy. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Electric Literature of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kim, Taeho; Stogios, Peter J.; Khusnutdinova, Anna N.; Nemr, Kayla; Skarina, Tatiana; Flick, Robert; Joo, Jeong Chan; Mahadevan, Radhakrishnan; Savchenko, Alexei; Yakunin, Alexander F. published the artcile< Rational engineering of 2-deoxyribose-5-phosphate aldolases for the biosynthesis of (R)-1,3-butanediol>, Name: (R)-Butane-1,3-diol, the main research area is engineering deoxyribosephosphate aldolase Bacillus crystal structure butanediol; 1,3-butanediol; 2-deoxyribose-5-phosphate aldolase (DERA); BH1352; Escherichia coli (E. coli); acetaldehyde condensation; aldo-keto reductase; biotechnology; crystal structure; protein engineering; site-directed mutagenesis.

Carbon-carbon bond formation is one of the most important reactions in biocatalysis and organic chem. In nature, aldolases catalyze the reversible stereoselective aldol addition between two carbonyl compounds, making them attractive catalysts for the synthesis of various chems. In this work, we identified several 2-deoxyribose-5-phosphate aldolases (DERAs) having acetaldehyde condensation activity, which can be used for the biosynthesis of (R)-1,3-butanediol (1,3BDO) in combination with aldo-keto reductases (AKRs). Enzymic screening of 20 purified DERAs revealed the presence of significant acetaldehyde condensation activity in 12 of the enzymes, with the highest activities in BH1352 from Bacillus halodurans, TM1559 from Thermotoga maritima, and DeoC from Escherichia coli. The crystal structures of BH1352 and TM1559 at 1.40-2.50 Å resolution are the first full-length DERA structures revealing the presence of the C-terminal Tyr (Tyr224 in BH1352). The results from structure-based site-directed mutagenesis of BH1352 indicated a key role for the catalytic Lys155 and other active-site residues in the 2-deoxyribose-5-phosphate cleavage and acetaldehyde condensation reactions. These experiments also revealed a 2.5-fold increase in acetaldehyde transformation to 1,3BDO (in combination with AKR) in the BH1352 F160Y and F160Y/M173I variants. The replacement of the WT BH1352 by the F160Y or F160Y/M173I variants in E. coli cells expressing the DERA + AKR pathway increased the production of 1,3BDO from glucose five and six times, resp. Thus, our work provides detailed insights into the mol. mechanisms of substrate selectivity and activity of DERAs and identifies two DERA variants with enhanced activity for in vitro and in vivo 1,3BDO biosynthesis.

Journal of Biological Chemistry published new progress about Bacillus halodurans (source of 2-deoxyribose-5-phosphate aldolase BH1352). 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, Name: (R)-Butane-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

de Ligt, Marlies; Bergman, Maaike; Fuentes, Rodrigo Mancilla; Essers, Hans; Moonen-Kornips, Esther; Havekes, Bas; Schrauwen-Hinderling, Vera B; Schrauwen, Patrick published the artcile< No effect of resveratrol supplementation after 6 months on insulin sensitivity in overweight adults: a randomized trial.>, Application of C14H12O3, the main research area is glycemic control; insulin resistance; intrahepatic lipid content; obesity; resveratrol.

BACKGROUND: Effects of resveratrol on metabolic health have been studied in several short-term human clinical trials, with conflicting results. Next to dose, the duration of the clinical trials may explain the lack of effect in some studies, but long-term studies are still limited. OBJECTIVES: The objective of this study was to investigate the effects of 6-mo resveratrol supplementation on metabolic health outcome parameters. METHODS: Forty-one overweight men and women (BMI: 27-35 kg/m2; aged 40-70 y) completed the study. In this parallel-group, double-blind clinical trial, participants were randomized to receive either 150 mg/d of resveratrol (n = 20) or placebo (n = 21) for 6 mo. The primary outcome of the study was insulin sensitivity, using the Matsuda index. Secondary outcome measures were intrahepatic lipid (IHL) content, body composition, resting energy metabolism, blood pressure, plasma markers, physical performance, quality of life, and quality of sleep. Postintervention differences between the resveratrol and placebo arms were evaluated by ANCOVA adjusting for corresponding preintervention variables. RESULTS: Preintervention, no differences were observed between the 2 treatment arms. Insulin sensitivity was not affected after 6 mo of resveratrol treatment (adjusted mean Matsuda index: 5.18 ± 0.35 in the resveratrol arm compared with 5.50 ± 0.34 in the placebo arm), although there was a significant difference in postintervention glycated hemoglobin (HbA1c) between the arms (P = 0.007). The adjusted means showed that postintervention HbA1c was lower on resveratrol (35.8 ± 0.43 mmol/mol) compared with placebo (37.6 ± 0.44 mmol/mol). No postintervention differences were found in IHL, body composition, blood pressure, energy metabolism, physical performance, or quality of life and sleep between treatment arms. CONCLUSIONS: After 6 mo of resveratrol supplementation, insulin sensitivity was unaffected in the resveratrol arm compared with the placebo arm. Nonetheless, HbA1c was lower in overweight men and women in the resveratrol arm. This trial was registered at Clinicaltrials.gov as NCT02565979.

The American journal of clinical nutrition published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application of C14H12O3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bettoni, Leo; Gaillard, Sylvain; Renaud, Jean-Luc published the artcile< Iron-Catalyzed α-Alkylation of Ketones with Secondary Alcohols: Access to β-Disubstituted Carbonyl Compounds>, Electric Literature of 403-41-8, the main research area is iron catalyzed alkylation ketone secondary alc borrowing hydrogen.

An iron-catalyzed borrowing hydrogen strategy has been applied in the synthesis of β-branched carbonyl compounds Various secondary benzylic and aliphatic alcs. have been used as alkylating reagents under mild reaction conditions. The ketones have been isolated in good to excellent yield. Deuterium labeling experiments provide evidence that the alc. is the hydride source in this reaction and that no reversible step or hydrogen/deuterium scrambling takes place during the process.

Organic Letters published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mahmud, N.; O’Toole, D.; O’Hare, N.; Freyne, P. J.; Weir, D. G.; Kelleher, D. published the artcile< Evaluation of renal function following treatment with 5-aminosalicylic acid derivatives in patients with ulcerative colitis>, SDS of cas: 6054-98-4, the main research area is mesalazine olsalazine aminosalicylate ulcerative colitis nephrotoxicity microalbuminuria prognosis.

A number of cases of nephrotoxicity have been reported in patients with inflammatory bowel disease taking oral 5-aminosalicylic acid (5-ASA). The aim of this study was to evaluate the effects of 9 mo of therapy with mesalazine or olsalazine on renal function in patients with ulcerative colitis in remission. Forty patients with ulcerative colitis in complete remission for 6 mo were randomized to either olsalazine (n = 20) or mesalazine (n = 20 for nine months). Thirty-six of the 40 patients were on prior salicylate therapy. Disease activity was the measure of clin. efficacy and was assessed by the Harvey-Bradshaw Index (HBI). Laboratory efficacy measurements included glomerular filtration rate (GFR), microalbuminuria, urinary glutathione S-transferase (GST) and serum C-reactive protein (CRP). Safety anal. consisted of documentation of adverse events and laboratory values. There was no significant reduction in the GFR overall on therapy. The levels of GFR adjusted for baseline were similar in the two treatment groups after 3, 6 and 9 mo. A significantly higher percentage of mesalazine-treated patients experienced drug related adverse events, all of a minor nature. The incidence of adverse events causing early withdrawal was similar in the two treatment groups. Treatment with mesalazine or olsalazine for 9 mo had no significant impact on GFR.

Alimentary Pharmacology and Therapeutics published new progress about C-reactive protein Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, SDS of cas: 6054-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tamoradi, Taiebeh; Ghadermazi, Mohammad; Ghorbani-Choghamarani, Arash published the artcile< Highly efficient, green, rapid, and chemoselective oxidation of sulfur-containing compounds in the presence of an MCM-41@creatinine@M (M = La and Pr) mesostructured catalyst under neat conditions>, Related Products of 699-12-7, the main research area is sulfide thiol oxidation catalyst preparation MCM41 creatinine lanthanum praseodymium.

The authors report the synthesis of two green recoverable catalysts by covalent linking of the creatinine La and Pr complexes on an MCM-41 mesostructure with the com. available materials and via a simple and inexpensive procedure. These heterogeneous catalysts were characterized by FTIR spectroscopy, energy-dispersive x-ray spectroscopy, SEM, N2 adsorption and desorption, inductively coupled plasma optical emission spectroscopy, and TGA. The obtained mesostructures act as active and reusable catalysts for the oxidation of sulfides and oxidative coupling of thiols under neat conditions. More importantly, significant practical advantages of this environmentally friendly process include high efficiency, good reaction times, and convenient recovery and reusability for several times without any significant loss of activity of the catalyst.

New Journal of Chemistry published new progress about Energy-dispersive x-ray spectroscopy. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Related Products of 699-12-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vezse, Panna; Benda, Bianka; Fekete, Andras; Golcs, Adam; Toth, Tunde; Huszthy, Peter published the artcile< Covalently Immobilizable Tris(Pyridino)-Crown Ether for Separation of Amines Based on Their Degree of Substitution>, Name: Triphenylmethanol, the main research area is amine separation trispyridinocrown ether mol recognition; biogenic amine; crown ether; molecular recognition; separation.

A great number of biol. active compounds contain at least one amine function. Appropriate selectivity can only be accomplished in a few cases upon the substitution of these groups, thus functionalization of amines generally results in a mixture of them. The separation of these derivatives with very similar characteristics can only be performed on a preparative scale or by applying pre-optimized HPLC methods. A tris(pyridino)-crown ether was designed and synthesized for overcoming these limitations at a mol. level. It is demonstrated, that this selector mol. is able to distinguish protonated primary, secondary and tertiary amines by the formation of reversible complexes with different stabilities. This degree of substitution-specific mol. recognition of amines opens the door to develop separation processes primarily focusing on the purification of biol. active compounds in a nanomolar scale.

Molecules published new progress about Crown ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Name: Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hedbom, Christina; Helgstrand, Erik; Misiorny, Alfons; Stjernstrom, Nils E.; Westin, Gertrud published the artcile< Potential hypolipidemic agents. II. Preparation of 5-halo-3-pyridylmethanols>, HPLC of Formula: 22620-34-4, the main research area is fluoronicotinate; nicotinate halo reduction; halopyridinemathanol; pyridine methanol halo.

The 3-pyridinemethanols (I, R = Br, Cl, F) were prepared in 40, 52, and 73% yields resp. by NaBH4 or KBH4 reduction of the corresponding Et halonicotinates. 5-Fluoronicotinic acid was prepared in 48% yield by diazotizing 5-aminonicotinic acid in HBF4-THF-H2O and decomposing the resulting salt in refluxing ligroine.

Acta Pharmaceutica Suecica published new progress about 22620-34-4. 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, HPLC of Formula: 22620-34-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Yu; Cen, Xuecong; Liu, Dehua; Chen, Zhen published the artcile< Metabolic engineering of Escherichia coli for high-yield production of (R)-1,3-butanediol>, Safety of (R)-Butane-1,3-diol, the main research area is metabolic engineering Escherichia butanediol fed batch fermentation; 1,3-butanediol; Escherichia coli; cofactor engineering; enzyme screening; metabolic engineering.

1,3-Butanediol (1,3-BDO) is an important C4 platform chem. widely used as a solvent in cosmetics and a key intermediate for the synthesis of fragrances, pheromones, and pharmaceuticals. The development of sustainable bioprocesses to produce enantiopure 1,3-BDO from renewable bioresources by fermentation is a promising alternative to conventional chem. routes and has aroused great interest in recent years. Although two metabolic pathways have been previously established for the biosynthesis of (R)-1,3-PDO, the reported titer and yield are too low for cost-competitive production In this study, we report the combination of different metabolic engineering strategies to improve the production of (R)-1,3-BDO by Escherichia coli, including (1) screening of key pathway enzymes; (2) increasing NADPH supply by cofactor engineering; (3) optimization of fermentation conditions to divert more flux into 1,3-BDO pathway; (4) reduction of byproducts formation by pathway engineering. With these efforts, the best engineered E. coli strain can efficiently produce (R)-1,3-BDO with a yield of 0.6 mol/mol glucose, corresponding to 60% of the theor. yield. Besides, we also showed the feasibility of aerobically producing 1,3-BDO via a new pathway using 3-hydroxybutyrate as an intermediate.

ACS Synthetic Biology published new progress about Escherichia coli. 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, Safety of (R)-Butane-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts