Month: October 2022

Li, Dan; Wang, Gangcheng; Jin, Guoguo; Yao, Ke; Zhao, Zhenjiang; Bie, Liangyu; Guo, Yongjun; Li, Ning; Deng, Wenying; Chen, Xiaobin; Chen, Beibei; Liu, Yuanyuan; Luo, Suxia; Guo, Zhiping published the artcile< Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway>, HPLC of Formula: 501-36-0, the main research area is resveratrol anticancer cell growth AKT STAT3 signaling colon cancer.

Colon cancer is a common type of cancer worldwide and accounts for a significant number of cancer-related deaths. Although surgical techniques and treatment strategies for colon cancer have advanced over the past two decades, the prognosis has not improved considerably. Resveratrol, a natural stilbene compound, possesses antioxidant, cardioprotective and anticancer properties. However, the role of resveratrol in colon cancer has not been fully elucidated. The present study demonstrated that resveratrol inhibited cell proliferation and colony growth in DLD1 and HCT15 colon cancer cells, but did not affect normal colon epithelial cells. The resveratrol-mediated inhibition of cell proliferation correlated with an induction of apoptosis and with G1 phase cell cycle arrest in colon cancer cells. Addnl., resveratrol treatment decreased the protein expression levels of cyclin D1, cyclin E2 and BCL2 apoptosis regulator, while it increased BCL2 associated X and tumor protein p53, all of which are involved in the regulation of cell cycle and apoptosis. Notably, the results obtained from in silico computational screening identified AKT serine/threonine kinase 1 (AKT1) and AKT2 as novel targets of resveratrol. Computational docking suggested that there are three or four possible hydrogen bonds in the active pocket of AKT1 and AKT2 that contribute to the mode of action of resveratrol. The present study confirmed that resveratrol bound to AKT1 and AKT2 with a pull-down assay. Furthermore, knockdown of AKT1 and AKT2 inhibited cell proliferation and colony growth, by attenuating cell cycle progression and increasing apoptosis in colon cancer cells, effects that were similar to those caused by resveratrol treatment. Taken together, the present results suggest that the targeting effects of resveratrol to AKT1 and AKT2 may be a potent strategy for chemoprevention or therapy for colon cancer.

International Journal of Molecular Medicine published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Das, Kanu; Yasmin, Eileen; Das, Babulal; Srivastava, Hemant Kumar; Kumar, Akshai published the artcile< Phosphine-free pincer-ruthenium catalyzed biofuel production: high rates, yields and turnovers of solventless alcohol alkylation>, COA of Formula: C8H9FO, the main research area is phosphine pincer ruthenium biofuel solventless alc alkylation.

Phosphine-free pincer-ruthenium carbonyl complexes based on bis(imino)pyridine and 2,6-bis(benzimidazole-2-yl) pyridine ligands have been synthesized. For the β-alkylation of 1-Ph ethanol with benzyl alc. at 140 °C under solvent-free conditions, (Cy2NNN)RuCl2(CO) (0.00025 mol%) in combination with NaOH (2.5 mol%) was highly efficient (ca. 93% yield, 372 000 TON at 12 000 TO h-1). These are the highest reported values hitherto for a ruthenium based catalyst. The β-alkylation of various alc. combinations was accomplished with ease which culminated to give 380 000 TON at 19 000 TO h-1 for the β-alkylation of 1-Ph ethanol with 3-methoxy benzyl alc. DFT studies were complementary to mechanistic studies and indicate the β-hydride elimination step involving the extrusion of acetophenone to be the overall RDS. While the hydrogenation step is favored for the formation of α-alkylated ketone, the alcoholysis step is preferred for the formation of β-alkylated alc. The studies were extended for the upgradation of ethanol to biofuels. Kinetic studies indicate first order dependence on concentration of both the catalyst and ethanol. Phosphine-free catalytic systems operating with unprecedented activity at a very low base loading to couple lower alcs. to higher alcs. of fuel and pharmaceutical importance are the salient features of this report.

Catalysis Science & Technology published new progress about Alkylation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, COA of Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Degraeuwe, Alexia; Jacobs, Marie-Claude; Herman, Anne published the artcile< Allergic contact dermatitis caused by resveratrol in a cosmetic cream.>, HPLC of Formula: 501-36-0 , the main research area is CAS number 501-36-0; allergic contact dermatitis; case report; cosmetics; resveratrol.

There is no abstract available for this document.

Contact dermatitis published new progress about 501-36-0 . 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guo, Fengyu; Liang, Qiong; Zhang, Ming; Chen, Wenxue; Chen, Haiming; Yun, Yonghuan; Zhong, Qiuping; Chen, Weijun published the artcile< Antibacterial activity and mechanism of linalool against Shewanella putrefaciens>, Computed Properties of 78-70-6, the main research area is Shewanella putrefaciens; antibacterial mechanism; linalool; metabolomics.

The demand for reduced chem. preservative usage is currently growing, and natural preservatives are being developed to protect seafood. With its excellent antibacterial properties, linalool has been utilized widely in industries. However, its antibacterial mechanisms remain poorly studied. Here, untargeted metabolomics was applied to explore the mechanism of Shewanella putrefaciens cells treated with linalool. Results showed that linalool exhibited remarkable antibacterial activity against S. putrefaciens, with 1.5 μL/mL min. inhibitory concentration (MIC). The growth of S. putrefaciens was suppressed completely at 1/2 MIC and 1 MIC levels. Linalool treatment reduced the membrane potential (MP); caused the leakage of alk. phosphatase (AKP); and released the DNA, RNA, and proteins of S. putrefaciens, thus destroying the cell structure and expelling the cytoplasmic content. A total of 170 differential metabolites (DMs) were screened using metabolomics anal., among which 81 species were upregulated and 89 species were downregulated after linalool treatment. These DMs are closely related to the tricarboxylic acid (TCA) cycle, glycolysis, amino acid metabolism, pantothenate and CoA biosynthesis, aminoacyl-tRNA biosynthesis, and glycerophospholipid metabolism In addition, linalool substantially affected the activity of key enzymes, such as succinate dehydrogenase (SDH), pyruvate kinase (PK), ATPase, and respiratory chain dehydrogenase. The results provided some insights into the antibacterial mechanism of linalool against S. putrefaciens and are important for the development and application of linalool in seafood preservation.

Molecules published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Computed Properties of 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Weil, Tatjana; Kirupakaran, Abbna; Le, My-Hue; Rebmann, Philipp; Mieres-Perez, Joel; Issmail, Leila; Conzelmann, Carina; Mueller, Janis A.; Rauch, Lena; Gilg, Andrea; Wettstein, Lukas; Gross, Ruediger; Read, Clarissa; Bergner, Tim; Palsson, Sandra Axberg; Uhlig, Nadja; Eberlein, Valentina; Woell, Heike; Klaerner, Frank-Gerrit; Stenger, Steffen; Kuemmerer, Beate M.; Streeck, Hendrik; Fois, Giorgio; Frick, Manfred; Braubach, Peter; Spetz, Anna-Lena; Grunwald, Thomas; Shorter, James; Sanchez-Garcia, Elsa; Schrader, Thomas; Muench, Jan published the artcile< Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses>, Application of C4H8O, the main research area is mol tweezer corona virus disease antiviral.

The COVID-19 pandemic caused by SARS-CoV-2 presents a global health emergency. Therapeutic options against SARS-CoV-2 are still very limited but urgently required. Mol. tweezers are supramol. agents that destabilize the envelope of viruses resulting in a loss of viral infectivity. Here, we show that first-generation tweezers, I and II, disrupt the SARS-CoV-2 envelope and abrogate viral infectivity. To increase the antiviral activity, a series of 34 advanced mol. tweezers were synthesized by insertion of aliphatic or aromatic ester groups on the phosphate moieties of the parent mol. I. A structure activity relationship study enabled the identification of tweezers with a markedly enhanced ability to destroy lipid bilayers and to suppress SARS-CoV-2 infection. Selected tweezer derivatives retain activity in airway mucus and inactivate the SARS-CoV-2 wildtype and variants of concern as well as respiratory syncytial, influenza, and measles viruses. Moreover, inhibitory activity of advanced tweezers against respiratory syncytial virus and SARS-CoV-2 was confirmed in mice. Thus, potentiated tweezers are broad-spectrum antiviral agents with great prospects for clin. development to combat highly pathogenic viruses.

JACS Au published new progress about Anticoronaviral agents. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Repossi, Gaston; Das, Undurti N.; Eynard, Aldo Renato published the artcile< Molecular Basis of the Beneficial Actions of Resveratrol>, Electric Literature of 501-36-0 , the main research area is review resveratrol gut microbiota transcription factor inflammation; Brain-derived neurotrophic factor; Cancer; Cytotoxic; Lipoxin A4; Metabolic syndrome; Polyunsaturated fatty acids; Resveratrol.

A review. Resveratrol modulates the transcription factor NF-κB, cytochrome P 450 isoenzyme CYP1A1, expression and activity of cyclooxygenase (COX) enzymes, Fas/Fas ligand mediated apoptosis, p53, mTOR and cyclins and various phospho-diesterases resulting in an increase in cytosolic cAMP levels. CAMP, in turn, activates Epac1/CaMKKβ/AMPK/SIRT1/PGC-1α pathway that facilitates increased oxidation of fatty acids, mitochondrial respiration and their biogenesis and gluconeogenesis. Resveratrol triggers apoptosis of activated T cells and suppresses tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17) and other pro-inflammatory mols. and inhibits expression of hypoxia inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) that may explain its anti-inflammatory actions. We observed that PUFAs (especially arachidonic acid, AA) and BDNF (brain-derived neurotrophic factor) protect against the cytotoxic actions of alloxan, streptozotocin, benzo(a)pyrene (BP) and doxorubicin. Thus, there is an overlap in the beneficial actions of resveratrol, PUFAs and BDNF suggesting that these mols. may interact and augment synthesis and action of each other. Since resveratrol is not easily absorbed from the gut it is likely that it may act on endocannabinoid and light, odor, and taste receptors located in the gut, which, in turn, convey their messages to the various organs via vagus nerve.

Archives of Medical Research published new progress about AMP-activated protein kinase activators. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Electric Literature of 501-36-0 .

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Niu, Junfeng; Wang, Shangping; Wang, Bulei; Chen, Lijun; Zhao, Guangming; Liu, Shuai; Wang, Shiqiang; Wang, Zhezhi published the artcile< Structure and anti-tumor activity of a polysaccharide from Bletilla ochracea Schltr.>, Application In Synthesis of 3458-28-4, the main research area is Bletilla polysaccharide structure antitumor activity; Anti-tumor; Bletilla ochracea; Immuno-modulation; Polysaccharide; Structure.

The polysaccharide fraction of Bletilla ochracea (BOP) was isolated from its tubers, and purified by DEAE-52 Cellulose and Sephadex G-200 column chromatog. The structural features of BOP were analyzed by GC-MS, HPLP, FT-IR, methylation and NMR. The average mol. weight of BOP was approx. 4.9 × 105 Da, and the monosaccharide composition was 7.88:2.12 mix of mannose and glucose. Although BOP had no effect on the proliferation rate of CT26 colon carcinoma cells, it significantly inhibited tumor xenograft growth in vivo by stimulating CD4+ T cell expansion in the spleen of the tumor-bearing mice. Taken together, BOP is a potent immunomodulatory agent that can be considered for anti-tumor therapy.

International Journal of Biological Macromolecules published new progress about Antitumor agents. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Application In Synthesis of 3458-28-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kirsch, Philine; Jakob, Valentin; Oberhausen, Kevin; Stein, Saskia C.; Cucarro, Ivano; Schulz, Thomas F.; Empting, Martin published the artcile< Fragment-Based Discovery of a Qualified Hit Targeting the Latency-Associated Nuclear Antigen of the Oncogenic Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8>, Formula: C9H8O, the main research area is Kaposi sarcoma human herpesvirus 8 antiviral LANA.

The latency-associated nuclear antigen (LANA) is required for latent replication and persistence of Kaposi’s sarcoma-associated herpesvirus/human herpesvirus 8. It acts via replicating and tethering the virus episome to the host chromatin and exerts other functions. We conceived a new approach for the discovery of antiviral drugs to inhibit the interaction between LANA and the viral genome. We applied a biophys. screening cascade and identified the first LANA binders from small, structurally diverse compound libraries. Starting from a fragment-sized scaffold, we generated optimized hits via fragment growing using a dedicated fluorescence-polarization-based assay as the structure-activity-relationship driver. We improved compound potency to the double-digit micromolar range. Importantly, we qualified the resulting hit through orthogonal methods employing EMSA, STD-NMR, and MST methodologies. This optimized hit provides an ideal starting point for subsequent hit-to-lead campaigns providing evident target-binding, suitable ligand efficiencies, and favorable physicochem. properties.

Journal of Medicinal Chemistry published new progress about Antiviral agents. 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Formula: C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kucinski, Krzysztof; Hreczycho, Grzegorz published the artcile< Lithium triethylborohydride as catalyst for solvent-free hydroboration of aldehydes and ketones>, Product Details of C8H9FO, the main research area is alc preparation green chem solvent free; aldehyde ketone hydroboration hydrolysis lithium triethylborohydride catalyst.

Com. available and inexpensive lithium triethylborohydride (LiHBEt3) acts as an efficient catalyst for the solvent-free hydroboration of a wide range of aldehydes and ketones, which were subsequently transformed to corresponding 1° and 2° alcs. in one-pot procedure at room temperature (rt).

Green Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Product Details of C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Yu; Cen, Xuecong; Liu, Dehua; Chen, Zhen published the artcile< Metabolic engineering of Escherichia coli for high-yield production of (R)-1,3-butanediol>, Safety of (R)-Butane-1,3-diol, the main research area is metabolic engineering Escherichia butanediol fed batch fermentation; 1,3-butanediol; Escherichia coli; cofactor engineering; enzyme screening; metabolic engineering.

1,3-Butanediol (1,3-BDO) is an important C4 platform chem. widely used as a solvent in cosmetics and a key intermediate for the synthesis of fragrances, pheromones, and pharmaceuticals. The development of sustainable bioprocesses to produce enantiopure 1,3-BDO from renewable bioresources by fermentation is a promising alternative to conventional chem. routes and has aroused great interest in recent years. Although two metabolic pathways have been previously established for the biosynthesis of (R)-1,3-PDO, the reported titer and yield are too low for cost-competitive production In this study, we report the combination of different metabolic engineering strategies to improve the production of (R)-1,3-BDO by Escherichia coli, including (1) screening of key pathway enzymes; (2) increasing NADPH supply by cofactor engineering; (3) optimization of fermentation conditions to divert more flux into 1,3-BDO pathway; (4) reduction of byproducts formation by pathway engineering. With these efforts, the best engineered E. coli strain can efficiently produce (R)-1,3-BDO with a yield of 0.6 mol/mol glucose, corresponding to 60% of the theor. yield. Besides, we also showed the feasibility of aerobically producing 1,3-BDO via a new pathway using 3-hydroxybutyrate as an intermediate.

ACS Synthetic Biology published new progress about Escherichia coli. 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, Safety of (R)-Butane-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts