Month: October 2022

Mortezaee, Keywan; Najafi, Masoud; Farhood, Bagher; Ahmadi, Amirhossein; Shabeeb, Dheyauldeen; Musa, Ahmed E. published the artcile< Resveratrol as an Adjuvant for Normal Tissues Protection and Tumor Sensitization>, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol anticancer agent cancer; Resveratrol; chemotherapy; molecular targeted therapy; neoplasm; radiation; radiotherapy; tumor microenvironment..

A review. Cancer is one of the most complicated diseases in present-day medical science. Yearly, several studies suggest various strategies for preventing carcinogenesis. Furthermore, experiments for the treatment of cancer with low side effects are ongoing. Chemotherapy, targeted therapy, radiotherapy and immunotherapy are the most common non-invasive strategies for cancer treatment. One of the most challenging issues encountered with these modalities is low effectiveness, as well as normal tissue toxicity for chemo-radiation therapy. The use of some agents as adjuvants has been suggested to improve tumor responses and also alleviate normal tissue toxicity. Resveratrol, a natural flavonoid, has attracted a lot of attention for the management of both tumor and normal tissue responses to various modalities of cancer therapy. As an antioxidant and anti-inflammatory agent, in vitro and in vivo studies show that it is able to mitigate chemo-radiation toxicity in normal tissues. However, clin. studies to confirm the usage of resveratrol as a chemo-radioprotector are lacking. In addition, it can sensitize various types of cancer cells to both chemotherapy drugs and radiation. In recent years, some clin. studies suggested that resveratrol may have an effect on inducing cancer cell killing. Yet, clin. translation of resveratrol has not yielded desirable results for the combination of resveratrol with radiotherapy, targeted therapy or immunotherapy. In this paper, we review the potential role of resveratrol for preserving normal tissues and sensitization of cancer cells in combination with different cancer treatment modalities.

Current Cancer Drug Targets published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Name: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Farkhondeh, Tahereh; Folgado, Silvia Llorens; Pourbagher-Shahri, Ali Mohammad; Ashrafizadeh, Milad; Samarghandian, Saeed published the artcile< The therapeutic effect of resveratrol: Focusing on the Nrf2 signaling pathway>, HPLC of Formula: 501-36-0, the main research area is resveratrol therapeutic Nrf signaling pathway review; Inflammation; Nrf2; Oxidative stress; Resveratrol; Therapeutic effects.

A review. Resveratrol is a natural polyphenol derived from grapes, berries, red wine, peanuts amongst other fruits and nuts. Beneficial effects such as anti-inflammatory, antioxidant, hepatoprotective, neuroprotective, cardioprotective, renoprotective, anti-obesity, anti-diabetic, and anti-cancer of resveratrol have been demonstrated by preclin. and clin. research. A possibility is that these therapeutical effects are associated with modulation of the Nrf2 signaling pathway in the following way: resveratrol may potentiate Nrf2 signaling through blockage of Keap1, by means of changing the Nrf2 mediators, its expression and its nuclear translocation. This article reviews the evidence of the Nrf2 modulating hypothesis as a possible mol. mechanism underlying the medicinal properties of resveratrol.

Biomedicine & Pharmacotherapy published new progress about Anti-inflammatory agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, HPLC of Formula: 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Weijuan; Zhang, Guohua published the artcile< Linalool monoterpene exerts potent antitumor effects in OECM 1 human oral cancer cells by inducing sub-G1 cell cycle arrest, loss of mitochondrial membrane potential and inhibition of PI3K/AKT biochemical pathway.>, SDS of cas: 78-70-6, the main research area is .

PURPOSE: Oral cancer is one of the prevalent types of cancer and has been reported to responsible for significant mortality and morbidity. Since treatment options for oral cancer are limited, there is need to explore novel molecules for treatment of oral cancer. In the current study we evaluated the anticancer activity of a plant derived monoterpene, Linalool against oral cancer cell line, OECM-1. METHODS: Cell viability was determined by MTT assay. Apoptosis was detected by DAPI and annexin V/PI staining. Cell cycle analysis was carried out by flow cytometry. Cell migration was assessed by wound healing assay and the expression of the proteins was determined by western blotting. RESULTS: The results showed that Linalool inhibited the viability of oral cancer OECM-1 cells in a concentration-dependent manner. The IC50 of Linalool against OECM-1 oral cancer cells was 10 µM as compared to its IC50 of 65 µM against non-cancer FR-2 cells. The anticancer effects were due to the induction of the apoptosis and sub-G1 cell cycle arrest. The results of annexin V/PI further revealed that the apoptotic cell populations increased from 2.6% in the control to 61.3% at 20 µM concentrations. It was observed that Linalool decreased the expression of p-PI3K and p-AKT in a concentration-dependent manner. However, the expression of PI3K and AKT remained almost unaltered. CONCLUSIONS: Taken together it was shown that Linalool monoterpene exerted significant anticancer effects in OECM-1 human oral cancer cells via inducing cell cycle arrest, loss of mitochondrial membrane potential (MMP) and suppressing PI3K/AKT signalling pathway.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology published new progress about 78-70-6. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, SDS of cas: 78-70-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Soszka, N.; Hachula, B.; Tarnacka, M.; Kaminska, E.; Pawlus, S.; Kaminski, K.; Paluch, M. published the artcile< Is a Dissociation Process Underlying the Molecular Origin of the Debye Process in Monohydroxy Alcohols?>, SDS of cas: 104-76-7, the main research area is glass former monohydroxy alc Debye relaxation hydrogen bond dissociation; activation barrier broad band dielec spectroscopy FTIR.

Herein, we investigated the mol. dynamics as well as intramol. interactions in two primary monohydroxy alcs. (MA), 2-ethyl-1-hexanol (2EHOH) and n-butanol (nBOH), by means of broad-band dielec. (BDS) and Fourier transform IR (FTIR) spectroscopy. The modeling data obtained from dielec. studies within the Rubinstein approach [Macromols. 2013, 46, 7525-7541] originally developed to describe the dynamical properties of self-assembling macromols. allowed us to calculate the energy barrier (Ea) of dissociation from the temperature dependences of relaxation times of Debye and structural processes. We found Ea ~19.4 ± 0.8 and 5.3 ± 0.4 kJ/mol for the former and latter systems, resp. On the other hand, FTIR data analyzed within the van’t Hoff relationship yielded the energy barriers for dissociation Ea ~20.3 ± 2.1 and 12.4 ± 1.6 kJ/mol for 2EHOH and nBOH, resp. Hence, there was almost a perfect agreement between the values of Ea estimated from dielec. and FTIR studies for the 2EHOH, while some notable discrepancy was noted for the second alc. A quite significant difference in the activation barrier of dissociation indicates that there are probably supramol. clusters of varying geometry or a ring-chain-like equilibrium is strongly affected in both alcs. Nevertheless, our anal. showed that the association/dissociation processes undergoing within nanoassocs. are one of the main factors underlying the mol. origin of the Debye process, supporting the transient chain model.

Journal of Physical Chemistry B published new progress about Activation energy. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, SDS of cas: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gu, Zixuan; Jiang, Haiyang; Zha, Fengchao; Manthey, Frank; Rao, Jiajia; Chen, Bingcan published the artcile< Toward a comprehensive understanding of ultracentrifugal milling on the physicochemical properties and aromatic profile of yellow pea flour>, Recommanded Product: 2-Ethylhexan-1-ol, the main research area is Pisum Starch damage Aromatic profile Untargeted metabolomics; Aromatic profile; Plant-based ingredients; Starch damage; Untargeted metabolomic approaches; Yellow pea.

Yellow pea (Pisum sativum L., YP) grain is generally milled into flour for further processing or direct consumption. However, the comprehensive relationship between milling configurations and YP flour properties remains unclear. The aim of this study is to investigate the effect of configurations (screen aperture size and rotor speed) of ultracentrifugal mill on the physicochem. properties and aromatic profiles of YP flours. Starch damage, morphol., particle size distribution, pasting, thermal property, and aromatic profiles of YP flours were studied. Results show that starch damage increased significantly as the screen aperture size decreased. The YP flour produced with a 500 μm aperture screen had the most stable pasting and thermal properties. With untargeted metabolomic approaches, 2-ethyl-1-hexanol could potentially be applied as an aroma maker to distinguish if an excessive milling or inappropriate configurations of ultracentrifugal mill are applied. This work has furnished fundamentals for the milling and application of YP flour.

Food Chemistry published new progress about Flours and Meals. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Recommanded Product: 2-Ethylhexan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Diamandas, Matthew; Moreira, Ryan; Taylor, Scott D. published the artcile< Solid-phase total synthesis of dehydrotryptophan-bearing cyclic peptides tunicyclin B, sclerotide A, CDA3a, and CDA4a using a protected β-hydroxytryptophan building block>, Safety of Triphenylmethanol, the main research area is cyclic peptide dehydrotryptophan solid phase total synthesis antibacterial agent; tunicyclin B sclerotide A CDA3a CDA4a hydroxytryptophan protected.

A new approach to the synthesis of Z-dehydrotryptophan (ΔTrp) peptides is described. This approach uses Fmoc-β-HOTrp(Boc)(TBS)-OH as a building block, which is readily prepared in high yield and incorporated into peptides using solid-phase Fmoc chem. The tert-butyldimethylsilyl-protected indolic alc. is eliminated during global deprotection/resin cleavage to give ΔTrp peptides exclusively as the thermodynamically favored Z isomer. This approach was applied to the solid-phase synthesis of tunicyclin B, sclerotide A, CDA3a, and CDA4a.

Organic Letters published new progress about Antibacterial agents. 76-84-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C19H16O, Safety of Triphenylmethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Zhenming; Zhang, Guihua; Teixeira da Silva, Jaime A.; Zhao, Conghui; Duan, Jun published the artcile< The methyl jasmonate-responsive transcription factor DobHLH4 promotes DoTPS10, which is involved in linalool biosynthesis in Dendrobium officinale during floral development>, Application of C10H18O, the main research area is helix loop transcription factor floral volatile terpene synthase; orchid methyl jasmonate linalool; Floral volatiles; MeJA; Orchids; Terpene synthase; bHLH transcription factor.

Linalool is an aromatic monoterpene produced in the Chinese medicinal plant Dendrobium officinale, but little information is available on the regulation of linalool biosynthesis. Here, a novel basic helix-loop-helix (bHLH) transcription factor, DobHLH4 from D. officinale, was identified and functionally characterized. The expression profile of DobHLH4 was pos. correlated with that of DoTPS10 (R2 = 0.985, p < 0.01), which encodes linalool synthase that is responsible for linalool production, during floral development. DobHLH4 was highly expressed in petals, and was significantly induced by Me jasmonate. Anal. of subcellular localization showed that DobHLH4 was located in the nucleus. Yeast one-hybrid and dual-luciferase assays indicated that DobHLH4 bound directly to the DoTPS10 promoter harboring the G-box element, and up-regulated DoTPS10 expression. A yeast two-hybrid screen confirmed that DobHLH4 phys. interacted with DoJAZ1, suggesting that DobHLH4 might function in the jasmonic acid-mediated accumulation of linalool. Furthermore, transient overexpression of DobHLH4 in D. officinale petals significantly increased linalool production by triggering linalool biosynthetic pathway genes, especially DoTPS10. We suggest a hypothetical model that depicts how jasmonic acid signaling may regulate DoTPS10 by interacting with DobHLH4 and DoJAZ1. In doing so, the formation of linalool is controlled. Our results indicate that DobHLH4 is a pos. regulator of linalool biosynthesis and may be a promising target for in vitro-based metabolic engineering to produce linalool. Plant Science (Shannon, Ireland) published new progress about Dendrobium catenatum. 78-70-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C10H18O, Application of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sanchez-Palomo, E.; Delgado, J. A.; Ferrer, M. A.; Vinas, M. A. Gonzalez published the artcile< The aroma of La Mancha Chelva wines: Chemical and sensory characterization>, Related Products of 104-76-7, the main research area is Vitis volatile aroma compound chem sensory property; Aromatic series, Sensory Analysis; Chelva white wine; Gas chromatography-mass spectrometry; Volatile aroma compounds.

The aim of this study is the chem. and sensory description of the aroma of wines white Chelva through five successive vintages. Solid Phase Extraction (SPE) was used for the isolation of volatile compounds and Gas Chromatog. Mass Spectrometry (GC-MS) was employed by their anal. Aroma Sensory Profile of wines was defined using the Quant. Descriptive Sensory Anal. (QDA). A total of 77 volatile compounds were identified in Chelva wines. Chelva wines present a great quantity of aromatic compounds of very different chem. nature and with different aromatic descriptors, which will increase its aromatic complexity of these wines. Aroma sensory profile of Chelva wines was defined by higher intensity of fresh and peach aromas with notes citric, green apple, tropical fruit and sweet. This study showed that the Chelva grapes variety cultivated in La Mancha region present a great aroma potential and a complex sensory profile and can be considered a viable alternative to traditional grape varieties cultivated in this region for increasing the offer to the consumer.

Food Research International published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Related Products of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Levinson, Robert A. published the artcile< Disodium azodisalicylate>, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate), the main research area is review azodisalicylate inflammatory bowel disease.

A review with 22 references on the use of azodisalicylate (I) [6054-98-4] in the treatment of inflammatory bowel disease.

American Journal of Gastroenterology published new progress about Inflammatory bowel disease. 6054-98-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H8N2Na2O6, Safety of Sodium 5,5′-(diazene-1,2-diyl)bis(2-hydroxybenzoate).

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ashikhmin, Alexander; Piskunov, Maxim; Yanovsky, Vyacheslav; Yan, Wei-Mon published the artcile< Properties and Phase Behavior of Water-in-Diesel Microemulsion Fuels Stabilized by Nonionic Surfactants in Combination with Aliphatic Alcohol>, Synthetic Route of 104-76-7, the main research area is property phase water diesel microemulsion fuel stabilization micellar; nonionic surfactant aliphatic alc emulsifier.

We study the properties and phase behavior of the H2O-diesel fuel-Neonol AF 9-6/2-ethylhexanol system, which is regarded as a promising microemulsion fuel. A pseudoternary diagram of the system has been obtained. In the diesel fuel/H2O (DF/W) ratio ranging from 98:2-50:50 and the emulsifier concentration of 8-40 volume%, a region of microemulsions has been distinguished, generating particular interest as an alternative fuel. In the region under study, a reverse micellar phase L2 has existed predominantly. Fish-cut diagrams have been obtained for the DF/W ratios in the emulsifier concentration-temperature coordinates. An increase in the H2O fraction in microemulsions significantly has narrowed the range of their stability. The critical changes of microemulsion properties have been identified using the fish-cut diagrams. We established the empirical relation among the phase inversion temperature, the emulsifier concentration in the phase inversion point, and the H2O fraction in microemulsions.

Energy & Fuels published new progress about Aliphatic alcohols Role: MOA (Modifier or Additive Use), USES (Uses). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Synthetic Route of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts