Month: September 2022

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 141699-55-0, formula is C8H15NO3, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Related Products of 141699-55-0

Barlaam, Bernard;Anderton, Judith;Ballard, Peter;Bradbury, Robert H.;Hennequin, Laurent F. A.;Hickinson, D. Mark;Kettle, Jason G.;Kirk, George;Klinowska, Teresa;Lambert-van der Brempt, Christine;Trigwell, Cath;Vincent, John;Ogilvie, Donald research published 《 Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors》, the research content is summarized as follows. Deregulation of HER family signaling promotes proliferation and tumor cell survival and has been described in many human cancers. Simultaneous, equipotent inhibition of EGFR-, HER2-, and HER3-mediated signaling may be of clin. utility in cancer settings where the selective EGFR or HER2 therapeutic agents are ineffective or only modestly active. We describe the discovery of AZD8931, I, an equipotent, reversible inhibitor of EGFR-, HER2-, and HER3-mediated signaling and the structure-activity relationships within this series. Docking studies based on a model of the HER2 kinase domain helped rationalize the increased HER2 activity seen with the Me acetamide side chain present in AZD8931. AZD8931 exhibited good pharmacokinetics in preclin. species and showed superior activity in the LoVo tumor growth efficacy model compared to close analogs. AZD8931 is currently being evaluated in human clin. trials for the treatment of cancer.

Related Products of 141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 533-73-3, formula is C6H6O3, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Recommanded Product: Benzene-1,2,4-triol

Barisic, Veronika;Flanjak, Ivana;Loncaric, Ante;Pichler, Anita;Jozinovic, Antun;Babic, Jurislav;Subaric, Drago;Milicevic, Borislav;Ackar, Djurdjica research published 《 Valorization of cocoa shell: Impact of high voltage electrical discharge and drying technology on properties of cocoa shell》, the research content is summarized as follows. There is a growing interest for use of cocoa shell for the enrichment of different food products and for resolving problem of disposal of shell. High voltage elec. discharge (HVED) is a non-thermal technol. that could solve problems linked to use of cocoa shell (contaminants and undesirable components). This paper investigated the broader impact of HVED on the properties of cocoa shells and how much influence drying (freeze- and oven- drying), which needs to be conducted, actually has on these properties. After the treatments, oil binding capacity increased in freeze-dried samples from 1.598 to 2.054 g/g. Also, water was easier to remove from HVED-treated oven-dried samples (by 1.75%). HPLC anal. showed that HVED caused better preservation of (-)-epicatechin and (-)-epicatechin gallate after oven-drying. Klason lignin contents slightly increased and differential scanning calorimetry showed higher thermostability of cocoa shell especially after HVED and freeze-drying because peak shifted for 11.54°C. Cocoa shell is a valuable byproduct of the chocolate industry, and it presents a problem for the environment. High voltage elec. discharge (HVED) would be a sustainable solution for this problem. After the HVED treatment, drying process is needed, and this study presents insights in a combination of these two technologies on cocoa shell properties. These results show that cocoa shells can be modified with these processes and are suitable for application in different food products.

Recommanded Product: Benzene-1,2,4-triol, Benzene-1, 2, 4-triol, also known as hydroxyhydroquinone or 1, 2, 4-benzenetriol, belongs to the class of organic compounds known as hydroxyquinols and derivatives. Hydroxyquinols and derivatives are compounds containing a 1, 2, 4-trihydroxybenzene moiety. Benzene-1, 2, 4-triol is soluble (in water) and a very weakly acidic compound (based on its pKa). Outside of the human body, benzene-1, 2, 4-triol can be found in tea. This makes benzene-1, 2, 4-triol a potential biomarker for the consumption of this food product.
Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.
1,2,4-Benzenetriol is a metabolite of benzene.
1,2,4-Benzenetriol is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.
1,2,4-Benzenetriol is a reactive molecule that has been shown to have hydrogen bonding interactions with copper chloride. It has been proposed as an inhibitor of methyltransferase, which is involved in the synthesis of methionine. Studies have shown that 1,2,4-Benzenetriol can also inhibit iron homeostasis and transfer reactions. The x-ray diffraction data for this compound shows that it forms a complex with the hydroxyl group. This complex is stabilized by hydrogen bonding interactions with the hydroxylic proton of the 1,2,4-benzenetriol molecule. 1,2,4-Benzenetriol has been shown to be toxic to HL-60 cells and K562 cells at concentrations greater than 5 mM. It has also been found to be effective against chlorogenic acids and other compounds in energy metabolism studies at concentrations between 0.5 and 2 mM., 533-73-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With respect to acute toxicity, simple alcohols have low acute toxicities. Doses of several milliliters are tolerated. 533-73-3, formula is C6H6O3, For pentanols, hexanols, octanols and longer alcohols, LD50 range from 2–5 g/kg (rats, oral). Ethanol is less acutely toxic.All alcohols are mild skin irritants. Recommanded Product: Benzene-1,2,4-triol

Balakrishnan, Akash;Gopalram, Keerthiga;Appunni, Sowmya research published 《 Photocatalytic degradation of 2,4-dicholorophenoxyacetic acid by TiO₂ modified catalyst: kinetics and operating cost analysis》, the research content is summarized as follows. Effective pesticide remediation technol. demands amendments in the advanced oxidation process for its continuous treatment and catalyst recovery. The evidence of 2,4-dichlorophenoxyacetic acid (2,4-D), an herbicide in water bodies, poses a major environmental threat to both humans and aquatic organisms. In the present study, a recirculation type photocatalytic reactor was developed to treat 2,4-dichlorophenoxyacetic acid using chitosan-TiO₂ beads prepared via impregnation method under UV light. At optimized conditions, chitosan-TiO₂ beads showed a maximum photocatalytic degradation of 86% than com. TiO₂ (65%) and followed pseudo first-order reaction. The 2,4-D degradation follows pseudo first-order kinetics under UV irradiation with a rate constant of 0.12 h^-1, and the intermediates were identified using LCMS anal. The total operational cost of the chitosan-TiO₂ catalyst was found to be profitable (Rs. 1323 for 2 L) than that of TiO₂ (Rs. 1679) at optimized conditions. The beads were reusable up to 4 consecutive cycles without loss in efficiency. This study briefs photocatalytic removal of 2,4-dichlorophenoxyacetic acid in a recirculation-type reactor for its reliability, low cost, efficiency, reusability, and commercialization.

Recommanded Product: Benzene-1,2,4-triol, Benzene-1, 2, 4-triol, also known as hydroxyhydroquinone or 1, 2, 4-benzenetriol, belongs to the class of organic compounds known as hydroxyquinols and derivatives. Hydroxyquinols and derivatives are compounds containing a 1, 2, 4-trihydroxybenzene moiety. Benzene-1, 2, 4-triol is soluble (in water) and a very weakly acidic compound (based on its pKa). Outside of the human body, benzene-1, 2, 4-triol can be found in tea. This makes benzene-1, 2, 4-triol a potential biomarker for the consumption of this food product.
Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.
1,2,4-Benzenetriol is a metabolite of benzene.
1,2,4-Benzenetriol is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.
1,2,4-Benzenetriol is a reactive molecule that has been shown to have hydrogen bonding interactions with copper chloride. It has been proposed as an inhibitor of methyltransferase, which is involved in the synthesis of methionine. Studies have shown that 1,2,4-Benzenetriol can also inhibit iron homeostasis and transfer reactions. The x-ray diffraction data for this compound shows that it forms a complex with the hydroxyl group. This complex is stabilized by hydrogen bonding interactions with the hydroxylic proton of the 1,2,4-benzenetriol molecule. 1,2,4-Benzenetriol has been shown to be toxic to HL-60 cells and K562 cells at concentrations greater than 5 mM. It has also been found to be effective against chlorogenic acids and other compounds in energy metabolism studies at concentrations between 0.5 and 2 mM., 533-73-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of C6H11NaO7, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 527-07-1, name is Sodium Gluconate, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Bai, Jing;Zhang, Yue;Xu, Chuanmeng;Sun, Chao;Liu, Huan;Lu, Mengmeng;Shao, Yi;Chu, Chenglin;Xue, Feng research published 《 Preparation and characterization of antibacterial oxide film with deposited silver on Al alloy》, the research content is summarized as follows. Aluminum (Al) alloy products are widely used in people′s lives, while the existence and breeding of microorganisms on their surface cannot meet the health criteria and even may harm human health. In the present study, we successfully prepared the antibacterial oxide film on the 6063 Al alloy specimens by direct-current anodizing followed by Ag element depositing and the hole sealing process. The results suggested that compared with the Al substrate, the wear resistance of the obtained film was increased to 0.79, and the corrosion resistance was significantly improved. The antibacterial rate against Escherichia coli could be achieved as 94.38 ± 3.23%, and the adhesion force between the film and substrate was about 11 N. With the increase of the deposition time, the surface color of samples was gradually darkened, and meanwhile, the surface became uniform again without particles eventually. Energy dispersive spectroscopy (EDS) results showed the silver element was deposited on the surface and at the bottom of the porous oxide layer, and the amount of silver also increased with prolonging the deposition time. Moreover, XPS anal. results on the surface showed the deposited silver element existed in the form of the ion and elemental substance, which indicated that reduction reaction of Ag⁺ appeared on the oxide film surface.

527-07-1, Sodium Gluconate is the sodium salt of gluconic acid with chelating property. Sodium gluconate chelates and forms stable complexes with various ions, preventing them from engaging in chemical reactions.
Sodium gluconate is an organic sodium salt having D-gluconate as the counterion. It has a role as a chelator. It contains a D-gluconate.
D-Gluconic acid sodium salt is a glycol ether that is used as an injection solution. It has been shown to have antibacterial efficacy against wild-type strains of bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The in vitro antimicrobial action of D-gluconic acid sodium salt was found to be due to its ability to inhibit bacterial growth by interfering with the synthesis of DNA. D-gluconic acid sodium salt also has been shown to have antihypertensive effects in rats through the inhibition of angiotensin II type 1 receptor (AT1) signaling pathway and erythrocyte proliferation. This drug also has been shown to bind benzalkonium chloride and x-ray diffraction data show that it is crystalline in nature. The analytical method for determining the concentration of D-gluconic acid sodium salt is by electrochemical impedance, Application of C6H11NaO7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 141699-55-0, formula is C8H15NO3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Category: alcohols-buliding-blocks

Bai, Chengfeng;Wu, Shuangjie;Ren, Shengnan;Zhu, Meiqi;Luo, Guoshun;Xiang, Hua research published 《 Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities》, the research content is summarized as follows. Estrogen receptor α emerged as a well validated therapeutic target of breast cancer for decades. However, approx. 50% of patients who initially respond to the standard-of-care (SoC), such as undergo therapy of Tamoxifen, generally inevitably progress to an endocrine-resistance ER+ phenotype. Recently, selective estrogen receptor covalent antagonists (SERCAs) targeted to ERα have demonstrated potential as therapeutic alternatives. In the present study, a series of novel 6-OH-benzothiophene (BT) derivatives targeting ERα and derived from Raloxifene were designed, synthesized, and biol. evaluated as covalent antagonists. Driven by the antiproliferative efficacy in ER+ breast cancer cells, chem. optimization finally led to compound I having potent antagonistic activity in ER+ tumor cells while not showing agonistic activity in endometrial cells. Moreover, a docking simulation was carried out to elucidate the binding mode, revealing I as an antagonist and covalently binding to the cysteine residue at the 530 position of ER helix H11.

141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocks, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Bach, Thorsten research published 《 The Paterno-Buechi reaction of 3-heteroatom-substituted alkenes as a stereoselective entry to polyfunctional cyclic and acyclic molecules》, the research content is summarized as follows. A review with >50 references on the preparation of 3-heteroatom-substituted oxetanes by the Paterno-Buechi reaction, and their application in synthesis. 3-Oxetanols and 3-aminooxetanes are the two most important oxetanes in this respect. By tuning the electronic properties of the enol and enamine substrates, a successful photocycloaddition to carbonyl compounds, with high yield, is possible. Since the oxetane formation proceeds stereoselectively, diastereomerically pure products are readily accessible, which can then be used in further transformations. To this end, regioselective ring-opening reactions have been developed, some of which will be discussed in this account.

Category: alcohols-buliding-blocks, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 72824-04-5, formula is C9H17BO2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Recommanded Product: 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Babin, Victor;Talbot, Alex;Labiche, Alexandre;Destro, Gianluca;Del Vecchio, Antonio;Elmore, Charles S.;Taran, Frederic;Sallustrau, Antoine;Audisio, Davide research published 《 Photochemical Strategy for Carbon Isotope Exchange with CO₂》, the research content is summarized as follows. A photocatalytic approach for carbon isotope exchange is reported. Utilizing [¹³C]CO₂ and [¹⁴C]CO₂ as primary C1 sources, this protocol allows the insertion of the desired carbon isotope into Ph acetic acids without the need for structural modifications or prefunctionalization in one single step. The exceptionally mild conditions required for this traceless transformation are in stark contrast with those for previous methods requiring the use of harsh thermal conditions.

Recommanded Product: 2-Allyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., 72824-04-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 16545-68-9, formula is C3H6O, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Category: alcohols-buliding-blocks

Babbs, Arran;Berg, Adam;Chatzopoulou, Maria;Davies, Kay E.;Davies, Stephen G.;Edwards, Benjamin;Elsey, David J.;Emer, Enrico;Guiraud, Simon;Harriman, Shawn;Lecci, Cristina;Moir, Lee;Peters, David;Robinson, Neil;Rowley, Jessica A.;Russell, Angela J.;Squire, Sarah E.;Tinsley, Jonathon M.;Wilson, Francis X.;Wynne, Graham M. research published 《 2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy》, the research content is summarized as follows. Utrophin modulation is a promising therapeutic strategy for Duchenne muscular dystrophy (DMD), which should be applicable to all patient populations. Following on from ezutromid, the first-generation utrophin modulator, we describe the development of a second generation of utrophin modulators, based on the bioisosteric replacement of the sulfone group with a phosphinate ester and substitution of the metabolically labile naphthalene with a haloaryl substituent. The improved physicochem. and absorption, distribution, metabolism, and excretion (ADME) properties, further reflected in the enhanced pharmacokinetic profile of the most advanced compounds, 30 and 27, led to significantly better in vivo exposure compared to ezutromid and alleviation of the dystrophic phenotype in mdx mice. While 30 was found to have dose-limiting hepatotoxicity, 27(I) and its enantiomers exhibited limited off-target effects, resulting in a safe profile and highlighting their potential utility as next-generation utrophin modulators suitable for progression toward a future DMD therapy.

Category: alcohols-buliding-blocks, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 24034-73-9, formula is C20H34O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Synthetic Route of 24034-73-9

Babarinde, Samuel Adelani;Olaniran, Oladele Abiodun;Ottun, Adebukola Taofikat;Oderinde, Abosede Elizabeth;Adeleye, Adetayo David;Ajiboye, Oludele;Dawodu, Ernest Olaolu research published 《 Chemical composition and repellent potentials of two essential oils against larger grain borer, Prostephanus truncatus (Horn.) (Coleoptera: Bostrichidae)》, the research content is summarized as follows. Larger grain borer {Prostephanus truncatus (Horn.) (Coleoptera: Bostrichidae)} is a polyphagous pest which infests timber products, cereals, legumes, dried yam and cassava chips. Its infestation causes quant. and qual. losses, leading to food insecurity and reduced income generation for farmers. Essential oils (EOs) were obtained from fresh leaves of Cymbopogon citratus (DC.) Stapf and Lantana camara Linn. via hydrodistillation using Clevenger type apparatus Each EO was assayed for repellent properties against P. truncatus using area preference methodol. while pure acetone served as control. The percentage of oil yield from C. citratus and L. camara was 0.263% and 0.221% v/w, resp. A total of 29 compounds were identified in C. citratus EO, dominated by oxygenated monoterpenes (92.58%), with citral (44.92%) and verbenol (34.97%) being the major compounds A total of 47 compounds were identified in L. camara EO, dominated by sesquiterpenes hydrocarbons (49.96%), with gamma-cadinene (21.93%) and delta-cadinene, (+)- (9.88%) being the major compounds When applied at 0.16 μL/cm², L. camara exhibited a significantly (p < 0.05) higher repellence of 95.00, 90.00, 80.00 and 75.00%, than 85.00, 70.00, 55.00 and 60.00% observed in C. citratus at 0.5, 1.0, 1.5 and 2.0 h after treatment, resp. The results elucidate the potentials of the EOs to prevent non-resident P. truncatus population from infesting stored products.

24034-73-9, Geranylgeraniol is a diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1. It has a role as a plant metabolite, a volatile oil component and an antileishmanial agent. It is a diterpenoid and a polyprenol.

Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro. When working with statins, Geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. Additionally Geranylgeraniol has been found to induce apoptosis in HL-60 cells.
, Synthetic Route of 24034-73-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 647-42-7, formula is C8H5F13O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Product Details of C8H5F13O

Ayala-Cabrera, J. F.;Moyano, E.;Santos, F. J. research published 《 Gas chromatography and liquid chromatography coupled to mass spectrometry for the determination of fluorotelomer olefins, fluorotelomer alcohols, perfluoroalkyl sulfonamides and sulfonamido-ethanols in water》, the research content is summarized as follows. In this work, the suitability of gas chromatog.-mass spectrometry (GC-MS) and liquid chromatog.-tandem mass spectrometry (LC-MS/MS) for the multi-class determination of different families of neutral per- and polyfluoroalkyl substances (PFASs), such as fluorotelomer olefins (FTOs), alcs. (FTOHs) and fluorooctanesulfonamides (FOSAs) and sulfonamido-ethanolxs (FOSEs), was investigated and compared. Regarding GC-MS, the use of a semi-polar GC column (DB-624, 6%-cyanopropilphenyl 94%-di-Me polysiloxane) allowed the adequate separation of all the compounds while chem. ionization (CI) of pos. ions as ionization technique provided the best responses. Concerning UHPLC-MS/MS, atm. pressure chem. ionization (APCI) and photoionization (APPI) sources allowed the ionization of all studied neutral PFASs, including FTOs for the first time. High vaporizer temperatures (450°C) and acetonitrile/water mobile phase mixtures were required to favor the ionization of FTOs, with adequate ionization for FTOHs, FOSAs and FOSEs. The chromatog. separation, performed on a totally porous column (Luna C18), allowed the successful separation of the four families of neutral PFASs. After comparing the performance of the studied methods, the highest detectability was achieved using UHPLC-APCI-MS/MS and it was chosen in combination with a solid-phase extraction (SPE) procedure for the anal. of neutral PFASs in water samples. The whole method provided low limits of detection (0.003-6μg L^-1), good precision (RSD < 9%) and trueness (relative error < 10%). The methodol. was applied to the anal. of river water samples and the presence of some neutral PFASs were detected (8:2 FTO) and quantified (4:2 FTOH and N-EtFOSA) at low concentration levels (ng L^-1).

647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, also known as 1H,1H, 2H, 2H-Tridecafluoro-1-n-octanol , is a useful research compound. Its molecular formula is C8H5F13O and its molecular weight is 364.1 g/mol. The purity is usually 95%.

1H,1H, 2H, 2H-Tridecafluoro-1-n-octanol is a material used to improve nanotube composites. It is also used in the synthesis of a recyclable fluorous hydrazine carbothioate compound with NCS to catalyze the acetalization of aldehydes.

1H,1H,2H,2H-Tridecafluoro-1-n-octanol is a potent and selective halogenated hydrocarbon. It binds to DNA at the dinucleotide phosphate site, which is an important site for polymerase chain reaction (PCR) activation. 1HFN has been shown to be more effective than other halogenated hydrocarbons in vitro assays on rat liver microsomes. It has been used as an additive in wastewater treatment to remove organic contaminants and metal ions. In vivo studies have been carried out in CD-1 mice to determine the effects of 1HFN on the liver and kidneys; these studies showed no toxicological effects on these organs. 1HFN also has been shown to inhibit enzymes such as cytochrome P450 and monoamine oxidase B that are involved in drug metabolism and may lead to adverse reactions with drugs metabolized by these enzymes., Product Details of C8H5F13O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts