Month: September 2022

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 24034-73-9, formula is C20H34O, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. COA of Formula: C20H34O

Calzada, Fernando;Ramirez-Santos, Jesica;Valdes, Miguel;Garcia-Hernandez, Normand;Pina-Jimenez, Emmanuel;Ordonez-Razo, Rosa Maria research published 《 Evaluation of Acute Oral Toxicity, Brine Shrimp Lethality, and Antilymphoma Activity of Geranylgeraniol and Annona macroprophyllata Leaf Extracts》, the research content is summarized as follows. In this study, we investigated the acute oral toxicity, brine shrimp lethality, and the antilymphoma activity of geranylgeraniol and the ethanolic and petroleum ether extracts of Annona macroprophyllata Donn.Sm., Annonaceae, leaves. Leaves were extracted by maceration with ethanol or petroleum ether. In acute oral toxicity anal., the ethanolic extract had a LD₅₀ of 1587 mg/kg, while the petroleum ether extract had an LD₅₀ of > 3000 mg/kg. This indicated that the petroleum ether extract may be less harmful than the ethanolic extract Furthermore, the petroleum ether extract showed low acute toxicity (category 5), significant brine shrimp lethality, and a high antilymphoma activity. Therefore, petroleum ether extract was purified by preparative thin layer chromatog. to yield geranylgeraniol. The results showed that geranylgeraniol (LC₅₀ = 1.00μg/mL) was more potent than methotrexate (LC₅₀ 24.66μg/mL), a known chemotherapy drug. Addnl., geranylgeraniol showed high antilymphoma activity in Balb/c mice injected i.p. with 1 x 10⁶ U-937 of human leukemic monocyte lymphoma cells, resulting in 50% effective inhibitory concentration (EC₅₀) values of 4.38 mg/kg and 3.66 mg/kg for male and female mice, resp. The antilymphoma activity of geranylgeraniol was similar to that of methotrexate (EC₅₀ = 1.07 mg/kg and 1.33 mg/kg, resp.). These findings suggest that geranylgeraniol may serve as a potential natural compound for the treatment of lymphoma.

24034-73-9, Geranylgeraniol is a diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1. It has a role as a plant metabolite, a volatile oil component and an antileishmanial agent. It is a diterpenoid and a polyprenol.

Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro. When working with statins, Geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. Additionally Geranylgeraniol has been found to induce apoptosis in HL-60 cells.
, COA of Formula: C20H34O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

COA of Formula: C3H6O, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 16545-68-9, name is Cyclopropanol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Cai, Xinpei;Liang, Weida;Liu, Mingxin;Li, Xiating;Dai, Mingji research published 《 Catalytic Hydroxycyclopropanol Ring-Opening Carbonylative Lactonization to Fused Bicyclic Lactones》, the research content is summarized as follows. A novel palladium-catalyzed ring opening carbonylative lactonization of readily available hydroxycyclopropanols was developed to efficiently synthesize THF (THF) or tetrahydropyran (THP)-fused bicyclic γ-lactones, two privileged scaffolds often found in natural products. The reaction features mild reaction conditions, good functional group tolerability, and scalability. Its application was demonstrated in a short total synthesis of (±)-paeonilide. The fused bicyclic γ-lactone products can be easily diversified to other medicinally important scaffolds, which further broadens the application of this new carbonylation method.

COA of Formula: C3H6O, Cyclopropanol is a cyclopropane in which a hydrogen atom is replaced by a hydroxy group. It is a member of cyclopropanes and an aliphatic alcohol.
Cyclopropanol is a useful research compound. Its molecular formula is C3H6O and its molecular weight is 58.08 g/mol. The purity is usually 95%.
Cyclopropanol is a cyclic organic compound that is synthesized from sodium hydroxide solution, nitrogen atoms, and carbonyl groups. Cyclopropanol has shown inhibitory effects on inflammatory bowel disease in rats. This drug also inhibits the production of hydrogen chloride and hydrochloric acid in the stomach, which can lead to ulcers. Cyclopropanol has been found to be effective against bowel diseases such as Crohn’s disease and ulcerative colitis. This drug has been shown to have strong antioxidant properties, which may be due to its ability to reduce hydroxyl radicals., 16545-68-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 533-73-3, formula is C6H6O3, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Name: Benzene-1,2,4-triol

Cai, Taimei;Deng, Qiang;Peng, Hailong;Zhong, Jin;Wang, Jun;Dai, Guiping;Zeng, Zheling;Zou, Ji-Jun;Deng, Shuguang research published 《 Selective Synthesis of Bioderived Dibenzofurans and Bicycloalkanes from a Cellulose-Based Route》, the research content is summarized as follows. The synthesis of dibenzofurans and bicycloalkanes from biomass is important for sustainable high-value chems. and high-d. fuels. Currently, their biomass-based precursor is mainly derived from lignin with limited yields. Herein, we propose a cellulose-based synthesis route for dibenzofurans with a yield of 72.3% via the integration of oxidative coupling of 1,2,4-benzenetriol to diphenol combined with subsequent dehydration under environmentally friendly reaction conditions. After hydrodeoxygenation, bicycloalkanes are obtained with a yield of 70.5% by catalysis performed over Pd/C and various zeolites. This work provides a powerful cellulose-based strategy for the synthesis of dibenzofurans and bicycloalkanes, which was previously unattainable in the conventional lignin-based route.

Name: Benzene-1,2,4-triol, Benzene-1, 2, 4-triol, also known as hydroxyhydroquinone or 1, 2, 4-benzenetriol, belongs to the class of organic compounds known as hydroxyquinols and derivatives. Hydroxyquinols and derivatives are compounds containing a 1, 2, 4-trihydroxybenzene moiety. Benzene-1, 2, 4-triol is soluble (in water) and a very weakly acidic compound (based on its pKa). Outside of the human body, benzene-1, 2, 4-triol can be found in tea. This makes benzene-1, 2, 4-triol a potential biomarker for the consumption of this food product.
Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite.
1,2,4-Benzenetriol is a metabolite of benzene.
1,2,4-Benzenetriol is an intermediary metabolite of benzene that is present in roasted coffee beans. It is mutagenic and it causes cleaving of DNA single strands by the generation of reactive oxygen species.
1,2,4-Benzenetriol is a reactive molecule that has been shown to have hydrogen bonding interactions with copper chloride. It has been proposed as an inhibitor of methyltransferase, which is involved in the synthesis of methionine. Studies have shown that 1,2,4-Benzenetriol can also inhibit iron homeostasis and transfer reactions. The x-ray diffraction data for this compound shows that it forms a complex with the hydroxyl group. This complex is stabilized by hydrogen bonding interactions with the hydroxylic proton of the 1,2,4-benzenetriol molecule. 1,2,4-Benzenetriol has been shown to be toxic to HL-60 cells and K562 cells at concentrations greater than 5 mM. It has also been found to be effective against chlorogenic acids and other compounds in energy metabolism studies at concentrations between 0.5 and 2 mM., 533-73-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 647-42-7, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Cai, Aijie;Yan, Wenhao;Wang, Chao;Liu, Wei research published 《 Copper-Catalyzed Difluoromethylation of Alkyl Iodides Enabled by Aryl Radical Activation of Carbon-Iodine Bonds》, the research content is summarized as follows. A novel strategy that leveraged the halogen abstraction ability of aryl radicals, thereby engaging a diverse range of alkyl iodides in copper-catalyzed Negishi-type cross-coupling reactions at room temperature Specifically, aryl radicals generated via copper catalysis efficiently initiate the cleavage of the carbon-iodide bonds of alkyl iodides. The alkyl radicals thus generated enter the copper catalytic cycles to couple with a difluoromethyl zinc reagent, thus furnished the alkyl difluoromethane products. This unprecedented Negishi-type difluoromethylation approach was applied to the late-stage modification of densely functionalized pharmaceutical agents and natural products.

647-42-7, 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, also known as 1H,1H, 2H, 2H-Tridecafluoro-1-n-octanol , is a useful research compound. Its molecular formula is C8H5F13O and its molecular weight is 364.1 g/mol. The purity is usually 95%.

1H,1H, 2H, 2H-Tridecafluoro-1-n-octanol is a material used to improve nanotube composites. It is also used in the synthesis of a recyclable fluorous hydrazine carbothioate compound with NCS to catalyze the acetalization of aldehydes.

1H,1H,2H,2H-Tridecafluoro-1-n-octanol is a potent and selective halogenated hydrocarbon. It binds to DNA at the dinucleotide phosphate site, which is an important site for polymerase chain reaction (PCR) activation. 1HFN has been shown to be more effective than other halogenated hydrocarbons in vitro assays on rat liver microsomes. It has been used as an additive in wastewater treatment to remove organic contaminants and metal ions. In vivo studies have been carried out in CD-1 mice to determine the effects of 1HFN on the liver and kidneys; these studies showed no toxicological effects on these organs. 1HFN also has been shown to inhibit enzymes such as cytochrome P450 and monoamine oxidase B that are involved in drug metabolism and may lead to adverse reactions with drugs metabolized by these enzymes., Reference of 647-42-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Quality Control of 7748-36-9

Buzard, Daniel J.;Kim, Sun Hee;Lehmann, Juerg;Han, Sangdon;Calderon, Imelda;Wong, Amy;Kawasaki, Andrew;Narayanan, Sanju;Bhat, Rohit;Gharbaoui, Tawfik;Lopez, Luis;Yue, Dawei;Whelan, Kevin;Al-Shamma, Hussien;Unett, David J.;Shu, Hsin-Hui;Tung, Shiu-Feng;Chang, Steve;Chuang, Ching-Fen;Morgan, Michael;Sadeque, Abu;Chu, Zhi-Liang;Leonard, James N.;Jones, Robert M. research published 《 Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists》, the research content is summarized as follows. A series of 5-fluoro-4,6-dialkoxypyrimidine GPR119 modulators were discovered and optimized for in vitro agonist activity. A lead mol. was identified that has improved agonist efficacy relative to our clin. compound (APD597) and possesses reduced CYP2C9 inhibitory potential. This optimized lead was found to be efficacious in rodent models of glucose control both alone and in combination with a Dipeptidyl peptidase-4 (DPP-4) inhibitor.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Quality Control of 7748-36-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 527-07-1, formula is C6H11NaO7, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. Synthetic Route of 527-07-1

Bruna, Roberto E.;Kendra, Christopher G.;Groisman, Eduardo A.;Pontes, Mauricio H. research published 《 Limitation of phosphate assimilation maintains cytoplasmic magnesium homeostasis》, the research content is summarized as follows. Phosphorus (P) is an essential component of core biol. mols. In bacteria, P is acquired mainly as inorganic orthophosphate (Pi) and assimilated into ATP (ATP) in the cytoplasm. Although P is essential, excess cytosolic Pi hinders growth. We now report that bacteria limit Pi uptake to avoid disruption of Mg2+-dependent processes that result, in part, from Mg2+ chelation by ATP. We establish that the MgtC protein inhibits uptake of the ATP precursor Pi when Salmonella enterica serovar Typhimurium experiences cytoplasmic Mg2+ starvation. This response prevents ATP accumulation and overproduction of rRNA that together ultimately hinder bacterial growth and result in loss of viability. Even when cytoplasmic Mg2+ is not limiting, excessive Pi uptake increases ATP synthesis, depletes free cytoplasmic Mg2+, inhibits protein synthesis, and hinders growth. Our results provide a framework to understand the mol. basis for Pi toxicity. Furthermore, they suggest a regulatory logic that governs P assimilation based on its intimate connection to cytoplasmic Mg2+ homeostasis.

527-07-1, Sodium Gluconate is the sodium salt of gluconic acid with chelating property. Sodium gluconate chelates and forms stable complexes with various ions, preventing them from engaging in chemical reactions.
Sodium gluconate is an organic sodium salt having D-gluconate as the counterion. It has a role as a chelator. It contains a D-gluconate.
D-Gluconic acid sodium salt is a glycol ether that is used as an injection solution. It has been shown to have antibacterial efficacy against wild-type strains of bacteria such as Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The in vitro antimicrobial action of D-gluconic acid sodium salt was found to be due to its ability to inhibit bacterial growth by interfering with the synthesis of DNA. D-gluconic acid sodium salt also has been shown to have antihypertensive effects in rats through the inhibition of angiotensin II type 1 receptor (AT1) signaling pathway and erythrocyte proliferation. This drug also has been shown to bind benzalkonium chloride and x-ray diffraction data show that it is crystalline in nature. The analytical method for determining the concentration of D-gluconic acid sodium salt is by electrochemical impedance, Synthetic Route of 527-07-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 141699-55-0, formula is C8H15NO3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Application of C8H15NO3

Boudreau, Marc A.;Ding, Derong;Meisel, Jayda E.;Janardhanan, Jeshina;Spink, Edward;Peng, Zhihong;Qian, Yuanyuan;Yamaguchi, Takao;Testero, Sebastian A.;O’Daniel, Peter I.;Leemans, Erika;Lastochkin, Elena;Song, Wei;Schroeder, Valerie A.;Wolter, William R.;Suckow, Mark A.;Mobashery, Shahriar;Chang, Mayland research published 《 Structure-Activity Relationship for the Oxadiazole Class of Antibacterials》, the research content is summarized as follows. A structure-activity relationship (SAR) for the oxadiazole class of antibacterials was evaluated by syntheses of 72 analogs and determination of the minimal-inhibitory concentrations (MICs) against the ESKAPE panel of bacteria. Selected compounds were further evaluated for in vitro toxicity, plasma protein binding, pharmacokinetics (PK), and a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) infection. Oxadiazole 72c shows potent in vitro antibacterial activity, exhibits low clearance, a high volume of distribution, and 41% oral bioavailability, and shows efficacy in mouse models of MRSA infection.

Application of C8H15NO3, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., 141699-55-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Application of C3H6O2

Born, Max;Plank, Jakob;Klapotke, Thomas M. research published 《 Energetic Polymers: A Chance for Lightweight Reactive Structure Materials?》, the research content is summarized as follows. Today′s ammunition still consists of about 70 wt% structure-providing materials such as metals providing no energetic contribution. Therefore, reactive structure materials (RSMs) offer tremendous room for improvement. While current research focuses on rather heavy, metal-based materials (e. g., alloys, thermites), energetic polymers appear as an under-recognized opportunity for very lightweight RSMs. Unfortunately, suitable polymers are unavailable as energetic polymer research has almost exclusively focused on elastic binders with the least possible glass transition temperature An application as RSM, however, requires rigid polymers with a glass transition above operational temperatures Accordingly, monomers with fundamentally different structures are required. The first step in this particular direction is 3-(2,4,6-trinitrophenoxy)oxetane (TNPO). Herein, we report the synthesis of its homopolymer and investigate its polymerization behavior by copolymerization with prior art energetic oxetanes. All polymers were intensively studied by vibrational and multinuclear (¹H, ¹³C, ¹⁴N) NMR spectroscopy, elemental anal., gel permeation chromatog., and differential scanning calorimetry (DSC). Hereby, DSC revealed the high effect of the TNPO repeating unit on the glass transition temperature The performance of all polymers was calculated using the EXPLO5 code to evaluate the potential performance range of polymeric RSMs. Further, their shock and friction sensitivity was determined by BAM standard procedures.

7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., Application of C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 7748-36-9, formula is C3H6O2, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Recommanded Product: Oxetan-3-ol

Born, Max;Fessard, Thomas C.;Goettemann, Lucas;Plank, Jakob;Klapoetke, Thomas M. research published 《 A GAP Replacement, Part 2: Preparation of Poly(3-azidooxetane) via Azidation of Poly(3-tosyloxyoxetane) and Poly(3-mesyloxyoxetane)》, the research content is summarized as follows. Despite the variety of energetic polyoxetane binders, the oxirane-based glycidyl azide polymer (GAP) has largely succeeded in the market due to its advantageous properties. Nevertheless, it suffers from various drawbacks such as non-uniform chain termination, possible chlorine content (flame retardant), and toxic epichlorohydrin required for its synthesis. These problems can be bypassed using the structurally related poly(3-azidooxetane). Unfortunately, it is only accessible in moderate yield by polymerization of 3-azidooxetane. Herein, we describe its synthesis by polymer-analogous transformation using the new polymers poly(3-tosyloxyoxetane) and poly(3-mesyloxyoxetane) as precursors. This results in a significantly increased yield and improved safety as handling of the very sensitive 3-azidooxetane is avoided. The aforementioned prepolymers were prepared using boron trifluoride etherate as well as triisobutylaluminum as catalysts. The latter provides polymers of particularly high mol. weight, and the corresponding poly(3-azidooxetane) species was obtained and studied for the first time. In order to shed light on the applicability of poly(3-azidooxetane) as a GAP substitute, it was thoroughly studied with regard to thermal behavior, energetic performance (EXPLO5), plasticizer compatibility, and curing. Moreover, the aquatic toxicity of all involved monomers was analyzed and compared to epichlorohydrin. Here, poly(3-azidooxetane) turned out as a fully adequate, if not more environmentally benign, substitute.

Recommanded Product: Oxetan-3-ol, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of 7748-36-9, In chemistry, an alcohol is a type of organic compound that carries at least one hydroxyl functional group (−OH) bound to a saturated carbon atom. 7748-36-9, name is Oxetan-3-ol, An important class of alcohols, of which methanol and ethanol are the simplest examples, includes all compounds which conform to the general formula CnH2n+1OH.

Born, Max;Karaghiosoff, Konstantin;Klapoetke, Thomas M. research published 《 A GAP Replacement: Improved Synthesis of 3-Azidooxetane and Its Homopolymer Based on Sulfonic Acid Esters of Oxetan-3-ol》, the research content is summarized as follows. In the field of energetic binders, only hydroxy-terminated glycidyl azide polymer (GAP) has found widespread application and prevailed in the market. However, oxiranes such as glycidyl azide (GA) allow two ring-opening modes during polymerization and thus lead to polymers of different termination causing inhomogeneous curing results. An elegant solution is the polymerization of 3-azidooxetane as only terminating primary hydroxyl groups are formed. Beyond this, poly(3-azidooxetane) and GAP are equal in other aspects due to the similar repetition unit. Since literature methods for the preparation of 3-azidooxetane either employed toxic solvents, gave low yields, or impurified product, or could not be reproduced, a new synthesis method was developed to afford pure material and satisfying yields. The syntheses of toluene- and methanesulfonic acid esters of oxetan-3-ol as precursors were also significantly improved in comparison to the literature and their mol. structures elucidated by single-crystal X-ray diffraction. The aforementioned compounds and poly(3-azidooxetane) were intensively studied by vibrational and multinuclear NMR spectroscopy (¹H, ¹³C, ¹⁴N), differential scanning calorimetry, and elemental anal. The key compound, 3-azidooxetane, was compared to glycidyl azide regarding performance using the EXPLO5 V6.04 thermochem. code and their sensitivity toward external stimuli like shock and friction assessed according to BAM standard procedures.

Application In Synthesis of 7748-36-9, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts