Month: September 2022

Dong, Kaiwu;Sang, Rui;Liu, Jie;Razzaq, Rauf;Franke, Robert;Jackstell, Ralf;Beller, Matthias published 《Palladium-Catalyzed Carbonylation of sec- and tert-Alcohols》 in 2017. The article was appeared in 《Angewandte Chemie, International Edition》. They have made some progress in their research.Safety of 2,5-Dimethyl-2,5-hexanediol The article mentions the following:

A general palladium-catalyzed synthesis of linear esters directly from sec- and tert-alcs. is described. Compared to the classic Koch-Haaf reaction, which leads to branched products, this new transformation gives the corresponding linear esters in high yields and selectivity. Key for this protocol is the use of an advanced palladium catalyst system with py^tbpx as the ligand. A variety of aliphatic and benzylic alcs. can be directly used and the catalyst efficiency for the benchmark reaction is outstanding (turnover number up to 89 000). To complete the study, the researchers used 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Safety of 2,5-Dimethyl-2,5-hexanediol

Reference:
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Related Products of 2425-77-6《Synthesis of helical branched carbodiimide polymers with liquid crystalline properties》 was published in 2022. The authors were De Silva, Enosha Harshani;Novak, Bruce M., and the article was included in《Liquid Crystals》. The author mentioned the following in the article:

Carbodiimide polymers are synthetic helical polymers that display unique properties depending on the functional groups attached to the polymer backbone. The amidine groups of the backbone present alternating amine- and imine-like groups. The properties of the polycarbodiimides have been studied by varying the sidechains of the polymer from linear to branched. In previous work, different arenes and straight aliphatic chains substituted polycarbodiimides have been used to evaluate the thermal and liquid crystalline properties of these polymers. In this study, we introduced bulky branched aliphatic and octadecyl side chains to the polymer backbone to generate a branched homopolymer and different branched/linear-chain copolymers. The effect of these side-chain combinations on the solid and solution properties of these polycarbodiimides was studied. It was observed that polycarbodiimides containing octadecyl and branched bulky alkyl groups showed different thermal events in the DSC plot at ∼30°C. Also, we observed a decrease in thermal stability in the TGA thermogram as we increase the branched alkyl side chains of the polymers. The lyotropic liquid crystallinity was observed in all the branched copolymers that consist of both branched alkyl side chains and octadecyl functional groups in different ratios. And 2-Hexyl-1-decanol (cas: 2425-77-6) was used in the research process.

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Related Products of 2425-77-6 This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

Reference:
Alcohol – Wikipedia,
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Du, Bibai;Li, Quan;Pan, Zibin;Zhang, Yun;Xie, Ruiman;Luo, Dan;Zeng, Lixi published 《Improved LC-MS/MS Method for the Simultaneous Determination of Synthetic Phenol Antioxidants and Relevant Metabolites Making Use of Atmospheric Pressure Chemical Ionization and a Trap Column》 in 2021. The article was appeared in 《Environmental Science & Technology Letters》. They have made some progress in their research.Electric Literature of C14H22O The article mentions the following:

The prevalently used LC-MS/MS methods for the simultaneous determination of synthetic phenol antioxidants (SPAs) and relevant metabolites suffer from a serious drawback of low sensitivity for 2,6-di-tert-butyl-4-hydroxytoluene (BHT) and a common issue of background contamination, which hampers the simple and accurate detection of these substances at trace levels in environmental samples. In this study, we developed an improved LC-MS/MS method for the simultaneous determination of eight SPAs and four relevant metabolites, including BHT. By use of atm. pressure chem. ionization (APCI), the sensitivity of BHT in the LC-MS/MS was enhanced approx. 260 times vs. results obtained by using electrospray ionization (ESI), which allowed the anal. of BHT up to 1.1 ng/g in indoor dust and 0.06 ng/g in human plasma. Similarly, the sensitivity of 2,4,6-tri-tert-butylphenol and 2,6-di-tert-butyl-4-sec-butylphenol was also enhanced with APCI, which avoided their sep. anal. by GC-MS. By installation of a C₁₈ column after the eluent mixer and before the injector as a trap column, the target analytes leached out from the LC system were eluted at a much later retention time than those in the samples, which resulted in complete elimination of the instrumental background contamination. These improvements enable the method to be well applied to the real samples. The experimental procedure involved many compounds, such as 4-tert-Octylphenol (cas: 140-66-9) .

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.Electric Literature of C14H22O It has been shown to cause harm to vertebrate male reproductive systems.

Reference:
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Escande, Vincent;Lam, Chun Ho;Grison, Claude;Anastas, Paul T. published 《EcoMnOx, a Biosourced Catalyst for Selective Aerobic Oxidative Cleavage of Activated 1,2-Diols》. The research results were published in《ACS Sustainable Chemistry & Engineering》 in 2017.Quality Control of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol The article conveys some information:

A novel catalyst, EcoMnOx, was prepared from waste biomass of Mn-hyperaccumulating plants. The valorization of this Mn-rich biomass is an alternative to its costly usual disposing and provides a new source of Mn. Extracted metal ions, including Mn²⁺, were oxidized in mild conditions by H₂O₂/NaOH to afford EcoMnOx, as a polymetallic oxide material containing from 8.9 to 14.1 wt % Mn. Spectroscopic studies of this material revealed the presence of Mn layered mixed oxides, rich in Mn^IV along with Mn^III and Mn^II species. EcoMnOx catalytic properties were assessed in the aerobic oxidative cleavage of 1,2-diols, under atm. pressure of O₂ or air. With only 10 mol % Mn, up to complete conversions were obtained on activated benzylic and allylic diols, with excellent selectivity toward aldehydes or ketones (98-99%). Moreover, because of its heterogeneous nature, the catalyst can be removed easily by filtration, and reapplied for a min. of six successive runs without any loss of activity. Finally, E-factor anal. showed the EcoMnOx generates 4 to 17 times less waste compared to classical reagents such as NaIO₄ and Pb(OAc)₄, resp., highlighting the sustainable assets of this new heterogeneous catalyst. And rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) was used in the research process.

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Quality Control of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

Reference:
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Fu, Jiantao;Zhao, Xu;Wang, Lanying;Zhang, Yunfei;Luo, Yanping published 《Antioxidant Activities and Allelopathic Potential of Chonemorpha splendens Chun et Tsiang Stem Methanol Extract》 in 2022. The article was appeared in 《Chemistry & Biodiversity》. They have made some progress in their research.Recommanded Product: 2425-77-6 The article mentions the following:

Finding agriculturally active compounds from nature or finding active lead compounds from natural products, artificial synthesis and structural modification are the main ways to create new agrochem. In order to explore the agricultural activities of Chonemorpha splendens Chun et Tsiang (C. splendens), an important medicinal plant, the antioxidant activities and allelopathic potential were investigated. C. splendens was extracted with methanol, then, C. splendens methanol extract (CSME) were extracted with petroleum ether, chloroform, Et acetate and butanol. Reducing activity, lipid peroxidation, and the scavenging abilities for DPPH·, O2-., HO·, and H2O2 were also measured and allelopathic potentials were evaluated by bioassay method. GC/MS anal. revealed that esters were the main component (66.34 %) of CSME, the total CSME flavonoid content was 313 mg g-1 (rutin equivalent). The chloroform phase of CSME was identified as stigmasterol by NMR for the first time. The DPPH· scavenging rate of CSME was 87 %, with an IC50 value of 0.12±0.02 mg mL-1, which was significantly difference from the pos. control, Trolox. Chloroform fraction showed the strongest inhibitory effect against Mimosa pudica (MP) seed germination at 1.0 mg mL-1 (100 % inhibition), which was better than that of the chem. herbicide paraquat. In the seed growth experiment, systematic EC50 and the principal component anal. (PCA) were used to assess the allelopathic potential of extracts The systematic EC50 values of Crotalaria pallida Ait. (CP), Bidens pilosa L. (BP) were significantly greater than MP. MP, Oryza sativa L. (OS) and Lactuca satiua L., (LS) inhibited all parameters. Our results would provide an idea for controlling weeds through allelopathy from C. splendens to reduce dependency on synthetic herbicides. The experimental procedure involved many compounds, such as 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) may be employed as an organic solvent to study the extraction of non-polar acidic drugs from human plasma by parallel artificial liquid membrane extraction (PALME). Recommanded Product: 2425-77-6

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Safety of 3,7-Dimethyloctan-3-olIn 2016, Radaelli, Marcela;da Silva, Barbara Parraga;Weidlich, Luciana;Hoehne, Lucelia;Flach, Adriana;da Costa, Luiz Antonio Mendonca Alves;Ethur, Eduardo Miranda published 《Antimicrobial activities of six essential oils commonly used as condiments in Brazil against Clostridium perfringens》. 《Brazilian Journal of Microbiology》published the findings. The article contains the following contents:

Despite recent advances in food production technol., food-borne diseases (FBD) remain a challenging public health concern. In several countries, including Brazil, Clostridium perfringens is among the five main causative agents of food-borne diseases. The present study determines antimicrobial activities of essential oils of six condiments commonly used in Brazil, viz., Ocimum basilicum L. (basil), Rosmarinus officinalis L. (rosemary), Origanum major ana L. (marjoram), Mentha × piperita L. var. Piperita (peppermint), Thymus vulgaris L. (thyme) and Pimpinella anisum L. (anise) against C. perfringens strain A. Chem. compositions of the oils were determined by GC-MS (gas chromatog.-mass spectrometry). The identities of the isolated compounds were established from the resp. Kováts indexes, and a comparison of mass spectral data was made with those reported earlier. The antibacterial activity was assessed from min. inhibitory concentration (MIC) and min. bactericidal concentration (MBC) using the microdilution method. Min. inhibitory concentration values were 1.25 mg mL-1 for thyme, 5.0 mg mL-1 for basil and marjoram, and 10 mg mL-1 for rosemary, peppermint and anise. All oils showed bactericidal activity at their min. inhibitory concentration, except anise oil, which was only bacteriostatic. The use of essential oils from these common spices might serve as an alternative to the use of chem. preservatives in the control and inactivation of pathogens in com. produced food systems. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Safety of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Wang, Ting;Guo, Zhi-yi;Wang, Jun-yi;Dayo, Abdul Qadeer;Liu, Wen-bin;Wang, Jun published 《Modification of traditional benzoxazine by blending with polyfunctional benzoxazines containing aromatic group and fluorene group》. The research results were published in《High Performance Polymers》 in 2021.Recommanded Product: 4-tert-Octylphenol The article conveys some information:

A series of polyfunctional benzoxazine monomers containing aromatic and fluorene group (AMFB) were used as modified agents to improve the performance of typical bifunctional bisphenol-A-aniline-based (BA-a) benzoxazine resins. The polymerization behaviors of BA-a/AMFB blends were investigated by using the differential scanning calorimetry (DSC), while the dynamic mech. anal. (DMA) and thermogravimetric anal. (TGA) were used to analyze the thermomech. and thermal properties of BA-a/AMFB copolymers [poly(BA-a/AMFB)]. Moreover, the cross-section morphologies of poly(BA-a/AMFB) were observed by scanning electron microscope (SEM). The exptl. results showed that BA-a monomer has good catalytic activity for AMFB monomers during the curing process. Compared with BA-a polymer [poly(BA-a)], due to the introduction of heat-resistant fluorene ring and the increase of the crosslinking degree of copolymers, the copolymers showed higher glass transition temperature and better thermal properties./. For poly(BA-a/AMFB), the T₅, T₁₀, and Y_c were higher than those of poly(BA-a). With the increase of the alkyl chain length of AMFB monomers, the cross-section creases gradually changed from linear to dendritic, and the number of creases increased significantly, which indicated that the toughness of the copolymers was significantly improved. And 4-tert-Octylphenol (cas: 140-66-9) was used in the research process.

4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.Recommanded Product: 4-tert-Octylphenol It has been shown to cause harm to vertebrate male reproductive systems.

Reference:
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Silva, Mariana P.;Nieva Lobos, Maria L.;Larson, Tony R.;McQueen-Mason, Simon;Gomez, Leonardo D.;Moyano, E. Laura;Scopel, Ana L. published 《Valuable chemicals identified from Flourensia species using vacuum and analytical pyrolysis》. The research results were published in《Journal of Analytical and Applied Pyrolysis》 in 2022.Reference of 2-Hexyl-1-decanol The article conveys some information:

The genus Flourensia, present throughout most of the Americas has been identified as a source of renewable chems. Here, we characterized the aerial biomass and matrix polysaccharides of Flourensia campestris, F. oolepis and F. riparia, and explored their potential as a source of chems. through the study of two techniques: anal. pyrolysis (PY-GC/MS) and vacuum pyrolysis (VP). In all species, hemicellulose was more abundant than cellulose and lignin, with galacturonic acid being the most abundant monosaccharide. Bio-oils from VP exhibited a complex combination of phenols, terpenes, furans and nitrogen-containing compounds which have a wide range of industrial applications. Differences between the composition of VP pyrolytic oils derived from the mixture of leaves and stems or from individual organs suggest possible interactions between biopolymers. Combining PY-GC/MS and principal component anal. (PCA) we identified fingerprints for leaves and stems of the three Flourensia species. The experimental procedure involved many compounds, such as 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) is a branched alcohol. It is one of the constituent of the essential oil, extracted from the roots of Adiantum flabellulatum. Reference of 2-Hexyl-1-decanol

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Arunachalam, Rajendran;Chinnaraja, Eswaran;Valkonen, Arto;Rissanen, Kari;Sen, Shovan K.;Natarajan, Ramalingam;Subramanian, Palani S. published 《Enantiomeric Resolution of Asymmetric-Carbon-Free Binuclear Double-Stranded Cobalt(III) Helicates and Their Application as Catalysts in Asymmetric Reactions》. The research results were published in《Inorganic Chemistry》 in 2018.Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diol The article conveys some information:

A series of double-stranded binuclear helicates [Co₂(H1)₂]⁴⁺, [Co₂(H2)₂]⁴⁺, and [Co₂(H3)₂]⁴⁺, derived from monodeprotonated bis-pyridyl hydrazine-based ligands of H₂1, H₂2, and H₂3 with one, two, and three -CH₂ spacers, were obtained. These asym.-carbon-free racemic helicates were separated into their ΔΔ and ΛΛ enantiomers. The resolved helicates were examined for the first time as enantioselective catalysts in asym. benzoylation and nitroaldol reactions. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Gu, Yilu;Tobino, Tomohiro;Nakajima, Fumiyuki published 《Determining the Relative Importance of Dietborne and Waterborne Toxicity of 4-tert-Butylphenol and 4-tert-Octylphenol to the Benthic Crustacean, Heterocypris incongruens》 in 2021. The article was appeared in 《Environmental Science & Technology》. They have made some progress in their research.Product Details of 140-66-9 The article mentions the following:

Organic pollutants with high solid-water equilibrium partition coefficients are adsorbed into solid particles and are easily ingested by benthic organisms, potentially causing dietborne toxicity. Whether dietborne toxicity is more important than waterborne toxicity for such chems. remains to be determined In this study, we identify the most relevant uptake route for the toxicity of two alkylphenols, 4-tert-butylphenol (4tBP), and 4-tert-octylphenol (4tOP). To achieve this, 6-day toxicity tests under two exposure conditions, namely dietary exposure (clean water + contaminated food) and combined exposure (contaminated water + contaminated food) were conducted on a benthic ostracod, Heterocypris incongruens. The toxicol. important exposure routes were confirmed by the consistency of dietary and aqueous dose-response relationships under different exposure conditions. During the test, frequent renewal of water and food was performed to reduce variability in the exposure conditions. The results showed that, under the equilibrium condition, the dietary exposure route was toxicol. more important than the aqueous route for 4tBP, whereas the waterborne exposure route was more important than the dietary exposure route for 4tOP. This study provides a novel approach to identify the most relevant uptake pathways for chem. toxicity, which better explains the importance of exposure routes in toxicity effects.4-tert-Octylphenol (cas: 140-66-9) were involved in the experimental procedure.

4-tert-Octylphenol(cas: 140-66-9) has been used as a reference standard for the determination of the analyte in water samples using ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS).Product Details of 140-66-9

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